DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and capn1

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_998624.1	Gene:	capn1 / 406768	ZFINID:	ZDB-GENE-040426-2814	Length:	704	Species:	Danio rerio

Alignment Length:	709	Identity:	203/709 - (28%)
Similarity:	339/709 - (47%)	Gaps:	77/709 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAAN 60
            :...||.:.:..:....|:|||.|.|..||:.:.:..|.:     .:|.|..::.
Zfish    33 LGQDYETLRAQSQQSRRLFEDPMFTASSSSLGFNELGPRSSKTQGVRWMRPKEMC---------- 87

  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
              |.|.|:.:.| ..|:..|.:||.||::.:..|:...||.:||||..|...|.: |:|.|:.|.
Zfish    88 --ARPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDNLLHRVVPHGQDFDSRYAGIFHFQFWQ 150

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||:|::||||||.:|:|.|:.......||:||||||.|||:|.||||..|:..:|..|..||
Zfish   151 FGEWVDVVIDDRLPTKDGKLLFVHSAEGGEFWSALLEKAYAKLNGCYEALSGGSTCEGFEDFTGG 215

  Fly   189 V-----VRQMPILSDNIRPQTLK--ELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRL 246
            |     :::.|....:|..:.::  .||..:..:|...|..|...||         ::....|.:
Zfish   216 VTEMYELKKAPADLFSIIGRAIERGSLLGCSIDITSKFDMEAVTFKK---------LVKGHAYSV 271

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :..::| ...|:..:||.:::     |:|| ..:.|.||..|:.|:.|.:..|.||..:...|||
Zfish   272 TGAEEV-VYRGNMTKLVRIRN-----PWGE-VEWTGAWSDNSREWDNVDRSVRGRLQNRSEDGEF 329

  Fly   312 WLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHIN 375
            |:||.||:..|:.:|:..|..:.....::.|     |....:.|:|:||.|||||||: .:|..|
Zfish   330 WMSFSDFLREFTRLEICNLTADALQASQVKK-----WSTANYNGEWRRGSTAGGCRNYPATFWNN 389

  Fly   376 PQLLISV-------QDEQDLVIALNQ-------HTAVEPKVIGFTMYTWDGEYM--LSECLQKDF 424
            ||..:::       |.|...::||.|       ....:.:.|||.:|....|::  ....|::||
Zfish   390 PQFKVALKHPDSPGQSECSFLVALMQKDRRKKRREGQDMETIGFAIYEVPREFLGQSGVHLKRDF 454

  Fly   425 FKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTM 488
            |..|.|...|: :.|.|.||....|.||.|:::|:|:||.:||.|.:|:..........::.:.|
Zfish   455 FLTHASSARSELFINLREVSSRFRLPAGEYIIVPSTFEPNKEADFVLRVFSEKPANSEEMDDKVM 519

  Fly   489 ILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--NDYIKGC 551
            ..:.....|..:..:          ..::.::.|||..:..|:..||..:|...:.  .|.....
Zfish   520 AEIPEEQRLDESQID----------AGFKSLFRQLAGADMEISVTELQTILNRIIAKHKDLKTDG 574

  Fly   552 ANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGF 616
            ...:.||.:|.|.|..|||::...:|......:|.:..:|:.:..:|:|.:.:..:|.||...||
Zfish   575 FGKESCRSMINLVDTDGSGKLGLVEFHVLWEKIKRYLQIFRDHDVDKSGTMSSYEMRKALETAGF 639

  Fly   617 QLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWI 675
            :|:..:...:|.||..:|.::...:|||.::.|.|.|..|...:.....||.:....||
Zfish   640 KLNNHLFQLIILRYTEEDLSVDFDNFVSCLVRLETMFKTFKSLDTDADGVISLTFFQWI 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	106/335 (32%)
		Calpain_III	346..483	CDD:238132	49/154 (32%)
		FRQ1	<567..648	CDD:227455	21/80 (26%)
capn1	NP_998624.1	Peptidase_C2	51..347	CDD:279042	105/323 (33%)
		Calpain_III	361..509	CDD:279416	49/147 (33%)
		EF-hand_8	547..606	CDD:290545	14/58 (24%)
		EFh	580..634	CDD:238008	14/53 (26%)
		EF-hand_7	612..698	CDD:290234	22/85 (26%)
		EFh	613..692	CDD:298682	22/78 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920