DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and zgc:85932

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_998104.1	Gene:	zgc:85932 / 405875	ZFINID:	ZDB-GENE-040426-2460	Length:	671	Species:	Danio rerio

Alignment Length:	702	Identity:	177/702 - (25%)
Similarity:	283/702 - (40%)	Gaps:	140/702 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LWEDPDFPA----VQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLNESA-EFDVV 77
            |:.|..||.    ||:.:.          |:|..::.            ..|.|:.:.| ..|:.
Zfish    45 LYVDTRFPVQNMPVQNDLV----------WRRPKEIC------------LFPQFIVDGATRMDIC 87

  Fly    78 PGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTING 141
            ...:||.|.:|.:..||....|..|||||.|.....: |.|.|:.|..|||:.|.:||.|||.|.
Zfish    88 QVVLGDCWFLSAVASLSLYPALLDRVVPAGQGFQQGYNGCFCFQFWQYGEWISVKIDDLLPTCNN 152

  Fly   142 RLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIRPQT-- 204
            :|.::...:.:.||:||||||.|||.|.|.||..|...:.:.|:.||:.....:.|   .|:.
Zfish   153 QLIYLHSASRDEFWSALLEKAYAKLKGGYSALNMGFPHEAMVDMTGGITEVFMVAS---LPRALG 214

  Fly   205 --LKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKD 267
              |:.||....::.| |:....:.|.|     ..|||....|.:::|:.||:.:| .||||.:::
Zfish   215 SFLRSLLEKGALINC-ANSQGPLEKSN-----EFGILFRHAYSVTALETVKSTIG-PVQLVRIRN 272

  Fly   268 TFSSKPFGEKTHFLGDWSPMSK-TWERVSQVERARLIR-QLGPGEFWLSFCDFVEIFSTMEVVYL 330
                 |:| |..:.|.||.... .|..|:..|:.|:.| |...||||:|..||.:.|..|||.:|
Zfish   273 -----PWG-KAEWEGPWSDKKGIEWHMVTAEEQRRVQRIQQEDGEFWMSLADFRQNFELMEVCHL 331

  Fly   331 DTETSNDEEMLKSRPLHWKMKMHQGQWK--RGVTAGGCRNHESFHINPQLLISVQDEQD------ 387
            ..:|.::.::.|.    ||...|.|||.  :|              :||..:::.:|.|
Zfish   332 SEDTLSEGDVKKP----WKCTSHHGQWTPLQG--------------SPQYNLTLLEEDDDPSDPE 378

  Fly   388 -----LVIALNQHTAVEPKVIGFTMYTWDG---------EYMLSECLQKDFFKNHVSYLNSDYGN 438
                 |:..:.:||.....::...::.:..         ..:||....:.|.:.....|.|
Zfish   379 LTCSFLLALMQKHTRQRGTLLSIALHIYKARDHGVSSRESPLLSTTKDQGFQQRPELVLRS---- 439

  Fly   439 TRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAE 503
                    .|..|||::||...|..:...|.:|:|           |:        ....:|.||
Zfish   440 --------RLAPGHYIIIPAIQETNQSGEFLLRVL-----------TE--------KGNTTTAAE 477

  Fly   504 RCGGPKVKSVCQYEPVYMQLADENKTINCF-------------ELHELLEACLPNDYIKG---CA 552
            |.|...........|....|...|:..:.|             :|:.||...:......|   ..
Zfish   478 RAGVATDSLTQPLSPRLTGLPSTNEARDLFVKHCAKGPYCRPLDLYNLLTEAISKGVFAGSEKML 542

  Fly   553 NIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQ 617
            :::.|:..:.|.|..|.||:...:|:.....|:.|..:|..:.|.|...|....:..||...|.:
Zfish   543 SLEHCKSFVVLMDSQGMGRLDLTEFQALWDKLRKWTSIFITFDKNKNQALDYLEISPALSAAGIK 607

  Fly   618 LSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHL---TTAFNQFHLKNYGQVNV 666
            :...|:..:..||...|.||....|:..::.|   ...|..|.:...|.::|
Zfish   608 VDEFILQLISLRYTEPDMTLSFPGFLFLLMKLDCMMRKFQSFDVTGTGMISV 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	103/322 (32%)
		Calpain_III	346..483	CDD:238132	29/158 (18%)
		FRQ1	<567..648	CDD:227455	20/80 (25%)
zgc:85932	NP_998104.1	Peptidase_C2	46..330	CDD:279042	102/321 (32%)
		Calpain_III	345..471	CDD:279416	30/170 (18%)
		FRQ1	572..>660	CDD:227455	21/88 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020