DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn1a

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_956739.1	Gene:	capn1a / 393417	ZFINID:	ZDB-GENE-040426-1263	Length:	704	Species:	Danio rerio

Alignment Length:	716	Identity:	211/716 - (29%)
Similarity:	346/716 - (48%)	Gaps:	97/716 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAANSSAA 64
            ||.:..:|.....|:|||.|||...|:.:.:..|.:     .:|.|..:|.|.
Zfish    35 YEALRQECLEGGYLFEDPCFPAEPPSLGFKELAPHSSKTRDVEWMRPTELCDD------------ 87

  Fly    65 PVFL-NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|: ..:...|:..|.:||.||::.:|.|:....|.:||||..|:....: |:|.|:.|..|||
Zfish    88 PQFIVGGATRTDICQGALGDCWLLAAIGSLTLNERLLHRVVPHGQSFQDDYAGIFHFQFWQFGEW 152

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV--- 189
            |::::|||||..:|.|.|:.....|.||:||:|||.|||:||||||..|:.::|..|..|||
Zfish   153 VDIVIDDRLPVKDGELMFVHSAEGNEFWSALVEKAYAKLNGSYEALSGGSTTEGFEDFTGGVSEM 217

  Fly   190 --VRQMPILSDNIRPQTLK--ELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLD 250
              :|:.|.....|..:.|.  .||..:..:|...|..:...||         ::....|.:::|.
Zfish   218 YELRKAPRDLYRIISKALDRGSLLGCSIDITSAFDMESVTFKK---------LVKGHAYSVTALK 273

  Fly   251 KVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSF 315
            :|: ..|...:|:.:::     |:|: ..:.|.||..|..|:.:...|:..|..|:..||||:||
Zfish   274 QVE-YRGRMERLIRIRN-----PWGQ-VEWTGAWSDNSPEWDEIDPSEKDDLHLQMEDGEFWMSF 331

  Fly   316 CDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLL 379
            .:|:..||.:|:..|..:..:|::|     .||......|.|:||.|||||||| .:|.||||..
Zfish   332 GEFLRQFSRLEICNLTPDALSDDDM-----SHWNTIKFHGAWRRGSTAGGCRNHPNTFWINPQYK 391

  Fly   380 ISVQDEQD----------LVIALNQ-------------HTAVEPKVIGFTMYTWDGEYMLSEC-- 419
            |::.:|.|          .::||.|             ||      |||.:|....||  :.|
Zfish   392 ITLLEEDDDPEDEEVACSFLVALMQKDRRRYRGQGQDMHT------IGFAIYEVPEEY--TGCQN 448

  Fly   420 --LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLS 481
              |:||||.::.|...|: :.|.|.||....|..|.|:::|:|:||::||.|.:|:     |...
Zfish   449 VHLKKDFFLSNSSAARSETFINLREVSTRLRLPPGEYIIVPSTFEPSKEADFVLRV-----FTEK 508

  Fly   482 CLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP-- 544
            ..||:.   ||...:....|.|......:..  .::.::.|||.|:..|:..||..:|...:.
Zfish   509 QSETEE---LDDEISADLEDEEEITEDDIDD--SFKSLFAQLAGEDMEISVHELKTILNRVVSKH 568

  Fly   545 NDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRD 609
            .|......::|.||.::.|.|:.||.|:...:|:.....::...|:|:.:..:|:|.:.:..:|.
Zfish   569 KDVKTDGFSMDSCRTMVNLLDKDGSARLGLVEFQILWNKIRKLLGIFREFDIDKSGTMSSYEMRL 633

  Fly   610 ALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDW 674
            |:...||:|:..:...|:.||...: .:...:||..:|.|...|..|...:..:....|::|.:|
Zfish   634 AVESAGFKLNNRLNQILVARYAENE-AIDFDNFVCCLIKLEAMFRSFQQLDREETGTAEMNLSEW 697

  Fly   675 I 675
            :
Zfish   698 L 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	104/335 (31%)
		Calpain_III	346..483	CDD:238132	57/165 (35%)
		FRQ1	<567..648	CDD:227455	18/80 (23%)
capn1a	NP_956739.1	Peptidase_C2	49..345	CDD:279042	102/323 (32%)
		Calpain_III	359..510	CDD:279416	56/163 (34%)
		EFh	581..631	CDD:298682	12/49 (24%)
		EFh	610..>664	CDD:298682	12/54 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920