DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn13

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001028616.1	Gene:	Capn13 / 381122	MGIID:	2685789	Length:	665	Species:	Mus musculus

Alignment Length:	733	Identity:	186/733 - (25%)
Similarity:	302/733 - (41%)	Gaps:	147/733 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RILSD-CRSKNVLWEDPDFPAVQSSV---FYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF 67
            |.|.| |.|:..|:.|..|||..||:   ..........:|||             ..|...|.:
Mouse    18 RTLRDHCLSRGQLFIDDTFPAAASSIGEKLLRGKHLSKLEWKR-------------PTSKDLPFY 69

  Fly    68 -----LNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGE 126
                 |..::.||:..|..||.|.::.||.|:.......::: .||:.:..: |:|:||.|.||:
Mouse    70 PPHFILEGASRFDIHQGIAGDCWFLAALGSLTQNPQCLQKIL-MDQSYSHQYAGIFQFRFWQCGQ 133

  Fly   127 WVEVLVDDRLPTINGRLAFMQPQASNC-FWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVV 190
            ||||::||:||.|.....|:.|:..|. ||..|:|||.|||.|||..|.||...|.|.||.||||
Mouse   134 WVEVVIDDQLPVIGDNFLFVHPRGGNKEFWPCLMEKAYAKLLGSYSQLHYGYLPDALVDLTGGVV 198

  Fly   191 RQMPILSDNIRP----QTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDK 251
               .|::.:..|    .|:|..:....:|.|..:...|    ..|:.|.||::....|.::..:|
Mouse   199 ---TIINLHSSPFDLLTTVKTAIQAGSMVACATENGLT----EEAKVMENGLVSQHAYTVTGAEK 256

  Fly   252 VKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFC 316
            :: ..|....::.|.:     |:| ||.:.|.|...||.|.......:::|......||||:|..
Mouse   257 IQ-YQGRWEDIIRLWN-----PWG-KTEWKGRWKDGSKEWRETHDPRKSQLYENKEDGEFWMSCQ 314

  Fly   317 DFVEIFSTMEV-----VYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHESFHINP 376
            ||.|.||.:.:     :.:|...:.:|.        |:......|......|||   |..   :.
Mouse   315 DFQENFSCLFICNQIPITMDHGVTPNES--------WRQMRFTNQVISRNRAGG---HGR---DM 365

  Fly   377 QLLISVQDEQDLVIALNQHTAVEPKVIGFT-----MYTWDGEYMLS-ECLQKDFFKN-------- 427
            |.:.|||          :|||....|:.||     :.|.:..:.|. :..:...|:|
Mouse   366 QYVFSVQ----------EHTAGNNVVVAFTIMPQSLNTEEERFPLQFQVFKVPQFQNVQGRLPPA 420

  Fly   428 HVSYLNSDYGNTRHVS-----YHTHLEAGHYVLIPTTYEPAEEAHFTVRIL---------GTGSF 478
            ..|...|....|::||     ...||..|.||::.|.  ..:|..|.:||.         .:.:|
Mouse   421 FFSPFRSAAQGTKYVSKCNFTKSFHLNPGTYVVVTTA--NGKEVEFLLRIFLKMPDKHRDPSSNF 483

  Fly   479 RLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACL 543
            .|..|:...                    |:..|.......||   |:...|:..:|..||.
Mouse   484 NLRALKESL--------------------PENGSRNSISYTYM---DQGLDIDATQLQSLLN--- 522

  Fly   544 PNDYIKG----CANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRA 604
             .:::.|    ..::|.|:.::||.|...:||:..::|......|...|.:|:. .:.:.|:|.:
Mouse   523 -QEFLTGPPGDTFSLDQCQSIMALMDLKVNGRLDQEEFARLRSRLIHCQHIFQS-IQRRPGVLLS 585

  Fly   605 ERL------RDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQF-HLKNYG 662
            ..|      .|.|  :|..:|:::::.:..||....|.:.....|..:|.|.|....| :|...|
Mouse   586 SDLWKVIENTDFL--VGIFISSELLSLMALRYSDSSGRVSFPTLVCFLIRLETMAKAFRNLSKDG 648

  Fly   663 Q-VNVIEVHLHDWIKSIL 679
            : :.:.|.   :|:..::
Mouse   649 KGIYLTET---EWMNLVM 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	106/341 (31%)
		Calpain_III	346..483	CDD:238132	37/164 (23%)
		FRQ1	<567..648	CDD:227455	17/86 (20%)
Capn13	NP_001028616.1	Peptidase_C2	31..327	CDD:279042	100/323 (31%)
Capn13	NP_001028616.1	Calpain_III	343..469	CDD:294111	34/143 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920