DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and capn8

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001231009.1	Gene:	capn8 / 337730	ZFINID:	ZDB-GENE-050522-279	Length:	701	Species:	Danio rerio

Alignment Length:	726	Identity:	209/726 - (28%)
Similarity:	349/726 - (48%)	Gaps:	106/726 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTF-----QWKRIMDLADSGSGAVAANSSAA 64
            |:.:..:|.:|..|:.||.|||...|:.|.:...::|     ||||..:|..:
Zfish    32 YQSLKQECLAKRALFCDPTFPAESDSLGYNELGRYSFKTKGVQWKRPKELCSN------------ 84

  Fly    65 PVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|:.:.| ..|:..|.:||.||::.:..|:..:.:..||||:.|:....: |:|.|:.|..|||
Zfish    85 PEFIMDGANRTDICQGALGDCWLLAAIASLTLDKEILERVVPSGQSFTEDYAGIFHFQFWQYGEW 149

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQ 192
            |:|::||||||.:|:|.|:.....:.||:||||||.||::||||||..|:.::|..|..||:...
Zfish   150 VDVVIDDRLPTRDGKLLFVHSAEGSEFWSALLEKAYAKVNGSYEALTGGSTTEGFEDFTGGITEN 214

  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVN-YRLSSLDKVKTLM 256
            ..:   :..|..|.:|:.....:..|...|..:......|.:.:..||..: |.:::.::|. ..
Zfish   215 YEL---SKAPPNLFKLVQKALALGSLLGCSIDITNSYETEAVTSLKLVKGHAYSVTAAEEVH-FR 275

  Fly   257 GDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDFVEI 321
            |..||||.:::     |:|| ..:.|.||..||.|:.|...|:|:|......||||:::.||::.
Zfish   276 GSLVQLVRIRN-----PWGE-VEWTGAWSDNSKEWDSVRPEEKAKLDYSAEDGEFWMAYSDFIQQ 334

  Fly   322 FSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQDE 385
            ||.:|:..|..:|.:.||:.:     |.....:|.|:.|.|||||||: .:|..|||.:|.:::.
Zfish   335 FSKLEICNLTPDTLSSEEVNR-----WSYSQFEGNWRVGSTAGGCRNNPATFCSNPQFMIKLEEI 394

  Fly   386 QD----------LVIALNQHTAVEPK-------VIGFTMYTWDGEY--MLSECLQKDFFKNHVSY 431
            .|          .::.|.|....:.|       .|||.:|....|.  ..:..|..|......|.
Zfish   395 DDDPHDGVNGCTFLVGLIQKDGRKDKRFGRDLNTIGFAIYKVPDELKGRSNIHLGPDVLLRQRSV 459

  Fly   432 LNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFP 495
            ..|: :.|.|.||....|..|.|::||:|:||..:..|.:|:.
Zfish   460 AGSNTFINLREVSERFKLPPGEYIIIPSTFEPHRKGSFILRVF---------------------- 502

  Fly   496 ALKSTDAERCGGPKVKSVCQ-----------YEPVYMQLADENKTINCFELHELLEACLPNDYIK 549
            |.|..||.:.|......|.:           ::.::.|:|..:..::..||.::|...:.    |
Zfish   503 AEKEADASQIGTEISADVKKHFISEKDIDPHFKRLFSQVAGSDSEVSVLELQQILNTVVS----K 563

  Fly   550 GCANI-------DICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERL 607
            ..:|:       :.||.:|:|.|:.|||::...:|.|..:.::.:..:||....:.:|.:.:..:
Zfish   564 RKSNVKTDGFSLETCRHIISLLDKDGSGKLGLLEFHTLWMKIQKYLEIFKHRDTDNSGTMSSLEM 628

  Fly   608 RDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHL---KNYGQVNVIEV 669
            |||:.:.||||:.|::..||.||..::..:....|||.:|.|...|..|.|   ||.|:   ||:
Zfish   629 RDAVKEAGFQLNNDVLEVLIARYANQEYAIDFDSFVSCLIRLELLFKMFQLFDKKNTGK---IEL 690

  Fly   670 HLHDWIKSILS 680
            .:..|:...||
Zfish   691 DILQWLCLALS 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	107/329 (33%)
		Calpain_III	346..483	CDD:238132	43/157 (27%)
		FRQ1	<567..648	CDD:227455	23/80 (29%)
capn8	NP_001231009.1	Peptidase_C2	46..342	CDD:279042	104/317 (33%)
		Calpain_III	356..507	CDD:279416	45/172 (26%)
		EFh	578..633	CDD:238008	16/54 (30%)
		EFh	607..691	CDD:298682	28/86 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020