DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn12

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_038967508.1	Gene:	Capn12 / 308476	RGDID:	1307341	Length:	766	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	196/722 - (27%)
Similarity:	312/722 - (43%)	Gaps:	131/722 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAANSSAA 64
            ||.|.:.|....:|:.||.|||...::.|.:..|.:     .:|||..:..            |.
  Rat    32 YEAIRAACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFC------------AE 84

  Fly    65 PVFLNES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|:.|. :..||..|.:|:.||::....|:....|.|||||..|.....: |||.|:||..|.|
  Rat    85 PQFICEDMSRTDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFGRW 149

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV--- 189
            |:|:|||:||..:|:|.|::.:..|.|||.|||||.||||||||.::.|..::...|..|||
  Rat   150 VDVVVDDKLPVRDGKLLFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEV 214

  Fly   190 --VRQ-MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDK 251
              :|| .|.:...:|....||.|..   .|.|:|:...        |...|::....|.::...|
  Rat   215 LYLRQNTPGVFAALRHALAKESLVG---ATALSDRGEI--------RTDEGLVKGHAYSVTGTHK 268

  Fly   252 VKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFC 316
            : :|....|:|:.|::     |:| :..:.|.||.....|:.:....|..|:.:...||||:...
  Rat   269 M-SLGFTKVRLLRLRN-----PWG-RVEWSGPWSDSCPRWDMLPSEWRDALLVKKEDGEFWMELQ 326

  Fly   317 DFVEIFSTMEVVYLDTETSNDEEMLKSRPL--HWKMKMHQGQWKRGVTAGGCR-NHESFHINPQL 378
            ||:..|:|:::..|      ..|:|...|.  .|.:...||:|.||..:||.: :.|:|..|||.
  Rat   327 DFLTHFNTVQICSL------SPEVLGPSPAGGGWHIHTFQGRWVRGFNSGGSQPSAENFWTNPQF 385

  Fly   379 LISV------QDEQD-------------------------LVIALNQHT--AVEPK-----VIGF 405
            .:::      :||.|                         ::::|.|..  .:..|     .:||
  Rat   386 RLTLLEPDEEEDEDDEEGPWGGWGAAGARPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGF 450

  Fly   406 TMY--------TWD---GEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTT 459
            .::        .||   ...:|...|:.|         .|.:...|.||....|..|||:::|:.
  Rat   451 HVFQIPEELLGLWDSPRSRALLPGLLRAD---------RSVFCARRDVSRRCRLPPGHYLVVPSA 506

  Fly   460 YEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLA 524
            ....:||.||:||....|        .|.:.:|.   :.|.|.:....|......:...::::||
  Rat   507 SRVGDEADFTLRIFSERS--------HTAVEIDD---VISADLDALQAPYKPLELELAQLFLELA 560

  Fly   525 DENKTINCFELHEL----LEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLK 585
            .|.:.:|..:|..|    ||....|....|...:..|.|::....|  ..|:....|:....:|.
  Rat   561 GEEEELNALQLQTLISIALEPARNNTRTSGEIGLRTCEQLVQCFGR--GQRLALYHFQELWGHLL 623

  Fly   586 SWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRL--SDFVSAVIH 648
            |||..|..:.::.:|.:.:..||.||...||.|:..:...|..||  ::..||:  ..||.....
  Rat   624 SWQATFDKFDEDASGTMNSCELRLALTAAGFHLNNQLTQALTSRY--RNSRLRVDFEHFVCCAAR 686

  Fly   649 LTTAFNQ 655
            ||..|.:
  Rat   687 LTCIFRE 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	105/334 (31%)
		Calpain_III	346..483	CDD:238132	42/188 (22%)
		FRQ1	<567..648	CDD:227455	22/82 (27%)
Capn12	XP_038967508.1	Peptidase_C2	46..339	CDD:395523	102/322 (32%)
		Calpain_III	352..530	CDD:238132	43/194 (22%)
		EFh_PEF	567..693	CDD:355382	35/129 (27%)
		EF-hand motif	596..623	CDD:320054	5/28 (18%)
		EF-hand motif	624..654	CDD:320054	9/29 (31%)
		EF-hand motif	660..688	CDD:320054	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920