Protein Alignment CalpC and Capn12

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_038967508.1
• Gene: Capn12 / 308476
• RGDID: 1307341
• Length: 766
• Species: Rattus norvegicus
• Alignment Length: 722
• Identity: 196/722 - (27%)
• Similarity: 312/722 - (43%)
• Gaps: 131/722 - (18%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAANSSAA 64
            ||.|.:.|....:|:.||.|||...::.|.:..|.:     .:|||..:..            |.
  Rat    32 YEAIRAACLDSGILFRDPCFPAGPDALGYDKLGPDSEKAKGVEWKRPHEFC------------AE 84

  Fly    65 PVFLNES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.|:.|. :..||..|.:|:.||::....|:....|.|||||..|.....: |||.|:||..|.|
  Rat    85 PQFICEDMSRTDVCQGSLGNCWLLAAAASLTLYPRLLYRVVPPGQGFQDGYAGVFHFQLWQFGRW 149

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV--- 189
            |:|:|||:||..:|:|.|::.:..|.|||.|||||.||||||||.::.|..::...|..|||
  Rat   150 VDVVVDDKLPVRDGKLLFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEV 214

  Fly   190 --VRQ-MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDK 251
              :|| .|.:...:|....||.|..   .|.|:|:...        |...|::....|.::...|
  Rat   215 LYLRQNTPGVFAALRHALAKESLVG---ATALSDRGEI--------RTDEGLVKGHAYSVTGTHK 268

  Fly   252 VKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFC 316
            : :|....|:|:.|::     |:| :..:.|.||.....|:.:....|..|:.:...||||:...
  Rat   269 M-SLGFTKVRLLRLRN-----PWG-RVEWSGPWSDSCPRWDMLPSEWRDALLVKKEDGEFWMELQ 326

  Fly   317 DFVEIFSTMEVVYLDTETSNDEEMLKSRPL--HWKMKMHQGQWKRGVTAGGCR-NHESFHINPQL 378
            ||:..|:|:::..|      ..|:|...|.  .|.:...||:|.||..:||.: :.|:|..|||.
  Rat   327 DFLTHFNTVQICSL------SPEVLGPSPAGGGWHIHTFQGRWVRGFNSGGSQPSAENFWTNPQF 385

  Fly   379 LISV------QDEQD-------------------------LVIALNQHT--AVEPK-----VIGF 405
            .:::      :||.|                         ::::|.|..  .:..|     .:||
  Rat   386 RLTLLEPDEEEDEDDEEGPWGGWGAAGARPARGGRVPKCTVLLSLIQRNRRCLRAKGLTYLTVGF 450

  Fly   406 TMY--------TWD---GEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTT 459
            .::        .||   ...:|...|:.|         .|.:...|.||....|..|||:::|:.
  Rat   451 HVFQIPEELLGLWDSPRSRALLPGLLRAD---------RSVFCARRDVSRRCRLPPGHYLVVPSA 506

  Fly   460 YEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLA 524
            ....:||.||:||....|        .|.:.:|.   :.|.|.:....|......:...::::||
  Rat   507 SRVGDEADFTLRIFSERS--------HTAVEIDD---VISADLDALQAPYKPLELELAQLFLELA 560

  Fly   525 DENKTINCFELHEL----LEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLK 585
            .|.:.:|..:|..|    ||....|....|...:..|.|::....|  ..|:....|:....:|.
  Rat   561 GEEEELNALQLQTLISIALEPARNNTRTSGEIGLRTCEQLVQCFGR--GQRLALYHFQELWGHLL 623

  Fly   586 SWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRL--SDFVSAVIH 648
            |||..|..:.::.:|.:.:..||.||...||.|:..:...|..||  ::..||:  ..||.....
  Rat   624 SWQATFDKFDEDASGTMNSCELRLALTAAGFHLNNQLTQALTSRY--RNSRLRVDFEHFVCCAAR 686

  Fly   649 LTTAFNQ 655
            ||..|.:
  Rat   687 LTCIFRE 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	105/334 (31%)
		Calpain_III	346..483	CDD:238132	42/188 (22%)
		EFh_PEF	515..680	CDD:355382	38/147 (26%)
		EF-hand motif	515..543	CDD:320054	8/31 (26%)
		EF-hand motif	556..585	CDD:320054	5/28 (18%)
		EF-hand motif	586..615	CDD:320054	9/28 (32%)
		EF-hand motif	622..650	CDD:320054	7/29 (24%)
		EF-hand motif	652..680	CDD:320054	1/4 (25%)
Capn12	XP_038967508.1	Peptidase_C2	46..339	CDD:459889	102/322 (32%)
		Calpain_III	352..530	CDD:238132	43/194 (22%)
		EFh_PEF	567..693	CDD:355382	35/129 (27%)
		EF-hand motif	596..623	CDD:320069	5/28 (18%)
		EF-hand motif	624..653	CDD:320069	9/28 (32%)
		EF-hand motif	660..688	CDD:320069	7/29 (24%)