DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and Capn2

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_058812.1	Gene:	Capn2 / 29154	RGDID:	2268	Length:	700	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	197/713 - (27%)
Similarity:	342/713 - (47%)	Gaps:	82/713 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAANSSAA 64
            ||.:.::|.....|::||.|||:.||:.:.:..|::     .:|||..::.            |.
  Rat    32 YETLRNECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKRPTEIC------------AD 84

  Fly    65 PVF-LNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127
            |.| :..:...|:..|.:||.||::.:..|:....:..||||.||:....: |:|.|:.|..|||
  Rat    85 PQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEW 149

  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV--- 189
            |||:|||||||.:|.|.|:.....:.||:||||||.||::|.||||..|..::|..|..||:
  Rat   150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEW 214

  Fly   190 --VRQMPILSDNIRPQTLKE--LLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLD 250
              :|:.|.....|..:.|::  ||..:..:|..||..|...:|         ::....|.::..:
  Rat   215 YELRKPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQK---------LVKGHAYSVTGAE 270

  Fly   251 KVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSF 315
            :|:: .|...:|:.:::     |:|: ..:.|.|:....:|..|....||.|..:...||||:||
  Rat   271 EVES-SGSLQKLIRIRN-----PWGQ-VEWTGKWNDNCPSWNTVDPEVRANLTERQEDGEFWMSF 328

  Fly   316 CDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLL 379
            .||:..:|.:|:..|..:|...:...|     ||:....|.|:||.|||||||: .:|.:|||.|
  Rat   329 SDFLRHYSRLEICNLTPDTLTCDSYKK-----WKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYL 388

  Fly   380 ISVQDEQD-----------LVIALNQHTAVEPKV------IGFTMYTWDGEY--MLSECLQKDFF 425
            |.:::|.:           ||..:.:|...:.|:      |||.:|....|.  ..:..|.|:||
  Rat   389 IKLEEEDEDDEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFF 453

  Fly   426 KNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMI 489
            ....:...|| :.|.|.|.....|..|.|||:|:|:||.:...|.:|:..........::.:...
  Rat   454 LTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDDEIEA 518

  Fly   490 LLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--NDYIKGCA 552
            .::...|    :.|..|.       .:..::.|||.|:..|:.|||..:|...|.  .|......
  Rat   519 NIEEIEA----NEEDIGD-------GFRRLFAQLAGEDAEISAFELQTILRRVLAKREDIKSDGF 572

  Fly   553 NIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQ 617
            :|:.|:.::.:.|..|||::..::|......::.:|.:::....:::|.:.:..:|.||.:.||:
  Rat   573 SIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFK 637

  Fly   618 LSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIK-SIL 679
            |...:...::.|:...:..:...:||..::.|...|..|...:......|::.|..|:. |:|
  Rat   638 LPCQLHQVIVARFADDELIIDFDNFVRCLVRLEILFKIFKQLDPENTGTIQLDLISWLSFSVL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	103/335 (31%)
		Calpain_III	346..483	CDD:238132	49/157 (31%)
		FRQ1	<567..648	CDD:227455	15/80 (19%)
Capn2	NP_058812.1	Peptidase_C2	46..342	CDD:279042	101/323 (31%)
		Domain III	345..514		51/173 (29%)
		Calpain_III	356..507	CDD:279416	49/150 (33%)
		Linker	515..529		1/17 (6%)
		Domain IV	530..700		37/176 (21%)
		EFh	577..631	CDD:238008	9/53 (17%)
		FRQ1	604..>696	CDD:227455	17/91 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920