DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn1

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_062025.1	Gene:	Capn1 / 29153	RGDID:	2267	Length:	713	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	204/716 - (28%)
Similarity:	340/716 - (47%)	Gaps:	85/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAAN 60
            :...||.:.:.|....||::|..||.|..|:.:.:..|     :..:|||..:|..:
  Rat    38 LGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSN-------- 94

  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
                |.|:.:.| ..|:..|.:||.||::.:..|:....:.:||||..|:....: |:|.|:||.
  Rat    95 ----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQ 155

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||:|:|||.|||.:|:|.|:.....|.||:||||||.||::||||||..|..|:...|..||
  Rat   156 FGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGG 220

  Fly   189 V-----VRQMPILSDNIRPQTLK--ELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRL 246
            |     :::.|.....|..:.|:  .||..:..::.:.|..| :..|||..          .:..
  Rat   221 VTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEA-ITFKNLVR----------GHAY 274

  Fly   247 SSLD-KVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGE 310
            |..| |..|..|..|.|:.:::     |:|| ..:.|.||..|..|.:|...||.:|..::..||
  Rat   275 SVTDAKQVTYQGQRVNLIRMRN-----PWGE-VEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGE 333

  Fly   311 FWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPL-HWKMKMHQGQWKRGVTAGGCRNH-ESFH 373
            ||:||.||:..|:.:|:..|..:.      ||||.| :|....::|.|:||.|||||||: .:|.
  Rat   334 FWMSFRDFIREFTKLEICNLTPDA------LKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFW 392

  Fly   374 INPQLLISVQDEQD-------------LVIALNQHTAVEPK------VIGFTMYTWDGEYMLSEC 419
            :|||..|.:::..|             |:..:.:|...|.:      .|||.:|....|......
  Rat   393 VNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPV 457

  Fly   420 -LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSC 482
             |::|||..:.|...|: :.|.|.||....|..|.|:::|:|:||.:|..|.:|...........
  Rat   458 HLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQE 522

  Fly   483 LETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--N 545
            |:.|....|.....|...:.:.          .::.::.:||.::..|:..||..:|...:.  .
  Rat   523 LDDQIQANLPDEKVLSEEEIDD----------NFKTLFSKLAGDDMEISVKELQTILNRIISKHK 577

  Fly   546 DYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDA 610
            |......:::.||.::.|.||.|:|::...:|......::::..:|:.:..:|:|.:.|..:|.|
  Rat   578 DLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMA 642

  Fly   611 LCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWI 675
            :...||:|:..:...:|.||...|..:...:||..::.|.|.|..|.:.:.....|:...|..|:
  Rat   643 IEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWL 707

  Fly   676 K 676
            :
  Rat   708 Q 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	109/336 (32%)
		Calpain_III	346..483	CDD:238132	47/159 (30%)
		FRQ1	<567..648	CDD:227455	18/80 (23%)
Capn1	NP_062025.1	Peptidase_C2	56..352	CDD:279042	106/324 (33%)
		Domain III	355..525		52/175 (30%)
		Calpain_III	366..518	CDD:279416	46/151 (30%)
		Linker	526..541		3/14 (21%)
		PTZ00184	537..680	CDD:185504	31/152 (20%)
		Domain IV	542..712		37/177 (21%)
		EF-hand_8	556..609	CDD:290545	12/52 (23%)
		EFh	589..643	CDD:238008	13/53 (25%)
		EFh	622..704	CDD:298682	20/81 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920