Protein Alignment CalpC and CAPN7

DIOPT Version :9

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_011531857.1
• Gene: CAPN7 / 23473
• HGNCID: 1484
• Length: 829
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 115/585 - (19%)
• Similarity: 207/585 - (35%)
• Gaps: 159/585 - (27%)

  Fly    40 TF-QWKRIMDLADSGSGAVAANSSAAPVFLNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRV 103
            || :|.|..||.::            |..:...:.|.:....:.|...|:.|.:.::....|.:.
Human   257 TFSKWVRPEDLTNN------------PTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKK 309

  Fly   104 V-----------------PADQTLASAH--GVFRFRLWWCG------EWVEVLVDDRLPTIN-GR 142
            :                 |..:.:...|  ||.|...:...      :...|::||:||..: |.
Human   310 LITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKNTYKLNISNLKIQNTPVIIDDQLPVDHKGE 374

  Fly   143 LAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIRPQTLK- 206
            |........:..|.:|:|||..|:.|.|:.....:..| |..|.|.:..::.:.||:   ||..
Human   375 LLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDS---QTFSK 435

  Fly   207 --------------ELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMG 257
                          ::|.|           |:......||....|::....|.:..:.:.|.|
Human   436 DNSFRMLYQRFHKGDVLIT-----------ASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGL-- 487

  Fly   258 DSVQLVCLKDTFS----SKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCDF 318
               :.:.||:.:|    ...:.|..  :.:|:|..:.:....    .|..:::..|.||:|:.|.
Human   488 ---RFIQLKNPWSHLRWKGRYSEND--VKNWTPELQKYLNFD----PRTAQKIDNGIFWISWDDL 543

  Fly   319 VEIFSTMEVVYLDTETSNDEEMLKSRPLH--WKMKMHQGQWKRGVTAGGCRNHESFHINPQLLIS 381
            .:.:   :|:||   :.|.....:|..:|  |..|.           |..::..|...|||..:.
Human   544 CQYY---DVIYL---SWNPGLFKESTCIHSTWDAKQ-----------GPVKDAYSLANNPQYKLE 591

  Fly   382 VQDEQD---LVIALNQHT------AVEPKVIGFTMYTWDGEYMLSECLQKDFF-KNHVSYLNSDY 436
            ||..|.   :.:.|::|.      |...:.|...:|..||        :|.:: .:...|::...
Human   592 VQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDG--------KKVYYPADPPPYIDGIR 648

  Fly   437 GNTRHVSYHTHLE----AGH-YVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPA 496
            .|:.|  |.|.::    ..| :.|:.:.||.....|:|||:....||..|.:.:       |:..
Human   649 INSPH--YLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPS-------PYTL 704

  Fly   497 LK-------STDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHE----LLEACLPNDYIKG 550
            .|       ...|..||.             .|...:|..|..|.:.:    |:|...|..|..|
Human   705 SKRINGKWSGQSAGGCGN-------------FQETHKNNPIYQFHIEKTGPLLIELRGPRQYSVG 756

  Fly   551  550
            Human   757  756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	62/334 (19%)
		Calpain_III	346..483	CDD:238132	35/153 (23%)
		FRQ1	<567..648	CDD:227455
CAPN7	XP_011531857.1	MIT_calpain7_1	5..76	CDD:239144
		MIT	85..159	CDD:294211
		CysPc	214..554	CDD:238004	64/340 (19%)
		calpain_III	703..826	CDD:214786	13/67 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810