DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and clp-6

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_500081.2	Gene:	clp-6 / 190738	WormBaseID:	WBGene00000546	Length:	627	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	152/498 - (30%)
Similarity:	240/498 - (48%)	Gaps:	60/498 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLNESAEFDV 76
            |..:|.|:|||.|||..||::|.:.|.....|.|        ...:.||..   :.:|..:.|||
Worm   151 CLDENRLFEDPQFPANNSSIYYKKPPKSHIVWLR--------PAKIFANPR---LIVNGKSRFDV 204

  Fly    77 VPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTIN 140
            ..|.:|:.|.::....|:....|||||||.||:....: |:|.|:.|..||||:|::||||||:|
Worm   205 RQGSLGNCWFLAAAATLAQRDELFYRVVPPDQSFTENYAGIFHFQFWRYGEWVDVVIDDRLPTVN 269

  Fly   141 GRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDN---IRP 202
            |:|.:|..|..:..|..|||||.|||:|:||.|..||.::.|.|..||:.....:.|.:   |..
Worm   270 GKLIYMSSQDGDECWGPLLEKAYAKLYGTYEHLDGGTTTEALEDFTGGLTEFYDLTSTDKTMILA 334

  Fly   203 QTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKD 267
            ..:|.:...: :..|..|......:..||    ||::....|.::.:..|:|   |..::..|:
Worm   335 MIMKGMQMGS-LFACSIDPDPREKEAQLA----NGLVRGHAYSVTGVHTVET---DKEKVALLR- 390

  Fly   268 TFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVEIFSTMEVVYLD 331
              ...|:|: |.:.||||..|..||:|.|.:|.:: .|....||||:...||:..|:.::...|.
Worm   391 --IRNPWGD-TEWNGDWSDKSSLWEQVDQEQREKMEFRIKEDGEFWMCLDDFMAQFANLDCCNLS 452

  Fly   332 TETSN------DEEMLKSRPLHWKMKMHQGQW-KRGVTAGGCRNHE-SFHINPQLLI-------S 381
            .:..:      :.|:::.:...|..|...|:| .|..|||||.|:| :|..|||...       |
Worm   453 ADVMHEITEMTEIEVMEKQSKQWIQKSADGEWCSRKGTAGGCSNNENTFCTNPQYETYFRATSPS 517

  Fly   382 VQDEQDLVIALNQ-------HTAVEPKVIGFTMYTWDGEYMLSECLQKDFFKNHVSYLNS----D 435
            ..|:..::.|:.|       |..::...||.::|...|.   :|.:..:..|.|....::    |
Worm   518 SNDKCTVIAAVFQKYRRNQLHRGLDMLQIGLSVYKMSGP---NEKVTAEMMKTHAPIASTKLFVD 579

  Fly   436 YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSF 478
            |   |.......:..|:||::|.|:||..:|.|.:|......|
Worm   580 Y---REAVVRFTVPPGYYVIVPCTFEPNHDAEFLLRTFSNVEF 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	108/321 (34%)
		Calpain_III	346..483	CDD:238132	42/153 (27%)
		FRQ1	<567..648	CDD:227455
clp-6	NP_500081.2	Peptidase_C2	158..450	CDD:366222	105/314 (33%)
clp-6	NP_500081.2	Calpain_III	473..624	CDD:238132	42/153 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920