DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and clp-8

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_493327.2	Gene:	clp-8 / 185746	WormBaseID:	WBGene00009695	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	92/358 - (25%)
Similarity:	164/358 - (45%)	Gaps:	71/358 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KYERILSDCRSKNVLWEDPDFP---------AVQSSVF----YYQTPPFTFQWKRIMDLADSGSG 55
            |::.||.||:.....:.|.:||         ..||.|:    .::|..|...|:||...:...|.
Worm    43 KFKSILEDCQRSKSAFIDKEFPHEPKSYMTFDEQSKVYGKYESWKTWLFPKIWRRITPPSTDVSS 107

  Fly    56 AVAANSSAAPVFLNESAEFDVVPGKMGDRWLVSCLGLLSS----LRNLFYRVVPADQTLASAHGV 116
            :::..:   |:..   ..::|...|:||..||:.|..:|:    :.|:|      |....|.:||
Worm   108 SLSVYN---PLTF---TAYEVFQRKVGDCGLVAALSAISTKPEVIMNIF------DSLQLSKYGV 160

  Fly   117 FRFRLWWCGEWVEVLVDDRLP-TINGRLAFMQPQASNCF--WAALLEKAIAKLHGSYEALKYGTR 178
            ::.:|:..|:|..:::||..| |.:|    ::..|::.:  ||||:|||:.|..|:|:.: :|.:
Worm   161 YKVKLFVDGQWKTIIIDDYFPYTTDG----IRIGATSGYQIWAALIEKALVKECGNYKGI-HGFQ 220

  Fly   179 S-DGLTDLLGGVVRQMPI--LSDNIRP--QTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGI 238
            | ...:.|.|..|..:|:  :.:|:|.  :||.|.......:.|           ....|..|||
Worm   221 SLSAFSALTGSPVLLIPVAKMFNNLRKYWKTLMEFRNNQYPMAC-----------GTLNREVNGI 274

  Fly   239 LVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLI 303
            |....|.:  :|.|:.   |..:|:.|::     |.|... :..:|   ||.||...: ....|:
Worm   275 LPQHAYTI--MDIVER---DGHKLLLLRN-----PSGGSV-WTRNW---SKEWEWWPE-NMKDLL 324

  Fly   304 RQLGPGEFWLSFCDFVEIFSTMEVVYLDTETSN 336
            ..:..|.||:|:.||:.:|.:   :|:....||
Worm   325 EGMIRGSFWISWDDFLNVFCS---IYVCRHRSN 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	88/346 (25%)
		Calpain_III	346..483	CDD:238132
		FRQ1	<567..648	CDD:227455
clp-8	NP_493327.2	CysPc	47..350	CDD:238004	89/348 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810