DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and tra-3

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_502751.1	Gene:	tra-3 / 178385	WormBaseID:	WBGene00006606	Length:	648	Species:	Caenorhabditis elegans

Alignment Length:	735	Identity:	184/735 - (25%)
Similarity:	280/735 - (38%)	Gaps:	209/735 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69
            ||::...|..|...:.|..||....|:|..|.......|||..:|...           ..:|:.
Worm    15 YEKLRKICIKKKQPFVDTLFPPTNQSLFLEQRQSSDIVWKRPGELHPD-----------PHLFVE 68

  Fly    70 ESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVP--ADQTLASAH---GVFRFRLWWCGEWVE 129
            .::..||..|.:|:.|.||....|:....|..:|:|  .||..::.|   |:||||.|..|:|||
Worm    69 GASPNDVTQGILGNCWFVSACSALTHNFKLLAQVIPDADDQEWSTKHAYAGIFRFRFWRFGKWVE 133

  Fly   130 VLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMP 194
            |::||.|||.:|:|.|.:.:..|.||:||||||.|||:|.||.|..|..||.|.|:.|||...:.
Worm   134 VVIDDLLPTRDGKLLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHLSDALQDVSGGVAETLH 198

  Fly   195 I---LSDNIRPQTLK---ELLTTTCIVTCLADKSATV-------AKKNLAERMPNGILVNVNYRL 246
            :   |.|:.....||   :|.|.       .||.|.|       .|:.:.|.:..|::....|.:
Worm   199 VRKFLKDDPNDTELKLFNDLKTA-------FDKGALVVAAIAARTKEEIEESLDCGLVKGHAYAV 256

  Fly   247 SSLDKVKT-----------LMGD--SVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVE 298
            |::..:..           :||.  ...|:.|::     |:||| .:.|.||..|..|:.||
Worm   257 SAVCTIDVTNPNERSFTSFIMGSKRKQNLIRLQN-----PWGEK-EWNGAWSDDSPEWQNVS--- 312

  Fly   299 RARLIRQLG---------PGEFWLSFCDFVEIFSTMEVVYL------DTETSNDEEMLKSRPLHW 348
             |..:..:|         .|:||:.:..||..|:.:.:..|      ....|.||:::.|
Worm   313 -ASQLSTMGVQPANSDSDDGDFWMPWESFVHYFTDISLCQLFNTSVFSFSRSYDEQIVFS----- 371

  Fly   349 KMKMHQGQW-----KRGV---TAGGCRNHE-SFHINPQLLISVQDEQ-DLVIALNQ--------- 394
                   :|     |.|.   .||||.|.: :|..|||.:..:.... .::.||.|
Worm   372 -------EWTTNGKKSGAPDDRAGGCHNFKATFCNNPQYIFDIPSPNCSVMFALIQNDPSEGLKK 429

  Fly   395 ----------------------HTAVEPKVIGFTMYTWDGEYMLSECLQKDFFKNHVSYLNSDYG 437
                                  |||:.|..|                              |||.
Worm   430 REPFVTIGMHVMKVENNRQYRVHTAMHPIAI------------------------------SDYA 464

  Fly   438 NTRHVSYHTH-LEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLDPFPALKSTD 501
            :.|.|..|.. |..|.|:|||||:.|.|:..|.:|:........|.|               :..
Worm   465 SGRSVYLHLQSLPRGRYLLIPTTFAPKEQTLFMLRVYSDEHIHFSPL---------------TKH 514

  Fly   502 AERCGGPKVKSVCQYEPVYMQLADENK----TINCFELHELLEACLPNDYIKGCANIDICRQVIA 562
            |.:.|..|.||......:.:...|.|.    |.|.:.:.:..........:.|..:|....|.:.
Worm   515 APKLGLLKCKSAQSVTRLTIHGVDFNSASTGTHNVYAILKDSRKSFRTKTLSGVKSIQWDEQFLF 579

  Fly   563 LQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLI 627
            .:.::.      ||:|     ::.|:.              .:..||.|      |:..::..||
Worm   580 HKSKNR------QQYK-----IEVWED--------------RKMARDHL------LAQSVIIALI 613

  Fly   628 QRYIRKDGTLRLSDFVSAVI 647
            ... .:|.||:|:|....||
Worm   614 DNE-NRDTTLQLTDPRGTVI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	108/361 (30%)
		Calpain_III	346..483	CDD:238132	39/178 (22%)
		FRQ1	<567..648	CDD:227455	17/81 (21%)
tra-3	NP_502751.1	CysPc	15..361	CDD:128526	111/373 (30%)
		Calpain_III	362..511	CDD:238132	43/190 (23%)
		C2_Calpain	526..646	CDD:176011	24/139 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780