DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and clp-7

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_500082.2	Gene:	clp-7 / 176953	WormBaseID:	WBGene00000547	Length:	778	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	161/507 - (31%)
Similarity:	248/507 - (48%)	Gaps:	68/507 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLNESAEFDV 76
            |..:..|:|||.|||..||::|...|.....|||        .|.:..|..   :.:.|.:.|||
Worm   304 CLDQRCLFEDPQFPANDSSLYYKTRPDEPIIWKR--------PGEIYENPQ---LIVGEKSRFDV 357

  Fly    77 VPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTIN 140
            ..|.:||.||::.:..|:....|||||||.||:....: |:|.|:.|..|:||:|::||||||::
Worm   358 KQGALGDCWLLAAVANLTLRDELFYRVVPPDQSFTENYAGIFHFQFWRYGQWVDVVIDDRLPTVD 422

  Fly   141 GRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIRPQTL 205
            |||.:|:.|.:|.||:||||||.|||:|.||.|..||.::.|.|..||:.....| |...:..||
Worm   423 GRLCYMRSQENNEFWSALLEKAYAKLYGGYENLDGGTTAEALEDFTGGLTEFFDI-SKGDKSTTL 486

  Fly   206 KEL---LTTTCIVTCLADKSATVAKKNLAE-RMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLK 266
            ..|   :....:..|..|     |.:|:.| ::.||::....|.::::..|.| .|..|.|:.::
Worm   487 AMLVRGMQMGSLFGCSID-----ADENVKEAQLTNGLVRGHAYSITAIQTVNT-YGGQVPLLRIR 545

  Fly   267 DTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVEIFSTMEVVYL 330
            :     |:|....:.|.||..|..|.:|...:|.:: ::....||||:||.||:..|:.||...|
Worm   546 N-----PWGNSKEWNGAWSDGSSEWSQVDPQQREQMGVQFAKDGEFWMSFDDFMTNFTQMECCNL 605

  Fly   331 DTETSNDEEMLKSRPLH------WKMKMHQGQW-KRGVTAGGCRNHESFHINPQLLISVQDEQDL 388
            ..:..::...:....:|      |..|...|:| .|..|||||:|::::..|||.....|...|.
Worm   606 SADVMDEISEMTGVEVHDKQKHQWVEKSEDGEWNSRQGTAGGCQNNDTYCNNPQYGTYFQVPMDS 670

  Fly   389 VIALNQHT-------AVEPKV-------------IGFTMYTWDGEYMLSECL--QKDFFKNHVSY 431
            |    :|.       ||..|.             |||::|..||.......:  ||...:..|
Worm   671 V----EHDGKCTVIGAVLQKYRRELRTKGLDNLPIGFSVYKADGSGQAIHDVSGQKPIARTKV-- 729

  Fly   432 LNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCL 483
                :.|.|.|:....:..|.||::|.|::..::|.|.:||.....|:.:.|
Worm   730 ----FINMREVTVRFRVPPGQYVIVPCTFDAHDDASFLLRIFSNAEFQTTRL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	115/322 (36%)
		Calpain_III	346..483	CDD:238132	44/165 (27%)
		FRQ1	<567..648	CDD:227455
clp-7	NP_500082.2	Peptidase_C2	311..604	CDD:366222	113/315 (36%)
clp-7	NP_500082.2	Calpain_III	627..777	CDD:238132	43/159 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020