DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and clp-1

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_498741.3	Gene:	clp-1 / 176122	WormBaseID:	WBGene00000542	Length:	780	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	161/503 - (32%)
Similarity:	249/503 - (49%)	Gaps:	64/503 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69
            || :...|.....|:|||.|.|..||:|:.:.||...:|.|..::            :..|..:.
Worm   304 YE-LRDQCLESKRLFEDPQFLANDSSLFFSKRPPKRVEWLRPGEI------------TREPQLIT 355

  Fly    70 ES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132
            |. :.|||:.|::||.||::....|:....|||||||.||:....: |:|.|:.|..|:||:|::
Worm   356 EGHSRFDVIQGELGDCWLLAAAANLTLKDELFYRVVPPDQSFTENYAGIFHFQFWQYGKWVDVVI 420

  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILS 197
            ||||||.||.|.:|...::|.||:||||||.|||.|||||||.||.|:.|.|:.||:...:.:.:
Worm   421 DDRLPTSNGELLYMHSASNNEFWSALLEKAYAKLFGSYEALKGGTTSEALEDMTGGLTEFIDLKN 485

  Fly   198 DNIRPQTLKELLTT--------TCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKT 254
            .   |:.|.:::..        .|.:.  ||.:...||      |.||::....|   |:...:.
Worm   486 P---PRNLMQMMMRGFEMGSLFGCSIE--ADPNVWEAK------MSNGLVKGHAY---SITGCRI 536

  Fly   255 LMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERV-SQVERARLIRQLGPGEFWLSFCDF 318
            :.|.:.|...|:   ...|:|.:..:.|.||..|:.|..| ..|::...::....||||:||.||
Worm   537 VDGPNGQTCILR---IRNPWGNEQEWNGPWSDNSREWRSVPDSVKQDMGLKFDHDGEFWMSFDDF 598

  Fly   319 VEIFSTMEVVYLDTETSNDEEML---KSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLL 379
            :..|..||:..|..:..::...:   |:..:.|....|.|.|.|..|||||||: .:|..|||..
Worm   599 MRNFEKMEICNLGPDVMDEVYQMTGVKAAGMVWAANTHDGAWVRNQTAGGCRNYINTFANNPQFR 663

  Fly   380 ISVQDEQ--------DLVIALNQ-------HTAVEPKVIGFTMYTWDGEYMLSECLQKDFFKNHV 429
            :.:.|..        .::.|:.|       ...::...|||.:|.....   ...|.|.||..:.
Worm   664 VQLTDSDPDDDDELCTVIFAVLQKYRRNLKQDGLDNVPIGFAVYDAGNN---RGRLSKQFFAANK 725

  Fly   430 SYLNS-DYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTG 476
            |.:.| .:.|.|.::....:..|:||::|:|:||.|||.|.:|:...|
Worm   726 SAMRSAAFINLREMTGRFRVPPGNYVVVPSTFEPNEEAEFMLRVYTNG 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	113/332 (34%)
		Calpain_III	346..483	CDD:238132	44/148 (30%)
		FRQ1	<567..648	CDD:227455
clp-1	NP_498741.3	Peptidase_C2	317..609	CDD:279042	111/320 (35%)
clp-1	NP_498741.3	Calpain_III	631..772	CDD:279416	43/143 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.970