DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and clp-4

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_497460.2	Gene:	clp-4 / 175326	WormBaseID:	WBGene00000545	Length:	716	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	156/527 - (29%)
Similarity:	247/527 - (46%)	Gaps:	85/527 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-FTFQWKRIMDLADSGSGAVAANSSAAPVFL 68
            :|.....|.....|:|||:|||..:|: ||:||| ....|||        .|.:.||    |..:
Worm   227 FETEREKCLRNKTLFEDPEFPATAASL-YYRTPPRDRIIWKR--------PGEIIAN----PQLI 278

  Fly    69 NE-SAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVL 131
            .: .:.|||..|.:||.|.::.|..::....||||:||.:|:....: |:|.|:.|..|:||:|:
Worm   279 TQGESRFDVKQGALGDCWFLAALANITLYDALFYRIVPPNQSFTENYAGIFHFQFWHYGKWVDVV 343

  Fly   132 VDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVV------ 190
            |||||||:|.:|.::....:..||:||:|||.|||||.||.|..||.::.|.|..||:.
Worm   344 VDDRLPTVNNQLYYLHSADNTEFWSALVEKAYAKLHGGYENLDGGTTAEALEDFTGGLTEYFDLR 408

  Fly   191 --RQMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVK 253
              .:..:|:..::...:..|.      .|..|..|.:.:..|.    ||::....|.::::..:
Worm   409 KSEKAAVLAALVKGMEMGSLF------GCSIDADANIKEAQLR----NGLVCGHAYSITAIHSI- 462

  Fly   254 TLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLG-PGEFWLSFCD 317
            |..|:...|:.|::     |:|.:..:.|.||..|..|.::.:..:.::..|.. .||||:||.|
Worm   463 TYYGEDTTLLRLRN-----PWGNEKEWNGAWSDGSSEWSKIDEATKKQIDVQFARDGEFWMSFED 522

  Fly   318 FVEIFSTMEVVYLD----------------TETSNDEEMLKSRPLHWKMKMHQGQW--KRGVTAG 364
            |...|:.|||..|.                |||..:|.       .|...|..|:|  |:| |||
Worm   523 FFSNFTQMEVCNLTAEIFDEIAEMTGVNRATETVEEEH-------QWHEIMEDGEWSSKKG-TAG 579

  Fly   365 GCRNHES----------FHINPQLLISVQDEQDLVIALNQHTAVEPK-------VIGFTMYTWDG 412
            ||.|:.|          |...||..|.......:::|:.|....|.:       .||.::|:...
Worm   580 GCNNNPSTYPKNPQFSTFFTAPQSSIEADGNVTVIVAVLQKYRRELRSKGKDVLPIGVSIYSLGA 644

  Fly   413 EYMLSECLQKDFF-KNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTG 476
            |......|...|| :|......:.:.|||.|:....:..|.||::|.|::..::|.|.:|:...|
Worm   645 EGTARSPLTAQFFSQNRPIARTTVFVNTREVTVRFRVPPGQYVIVPCTFDAYDDAEFLLRVYANG 709

  Fly   477 SFRLSCL 483
            :.:.|.|
Worm   710 TLKSSLL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	107/333 (32%)
		Calpain_III	346..483	CDD:238132	42/156 (27%)
		FRQ1	<567..648	CDD:227455
clp-4	NP_497460.2	Peptidase_C2	241..534	CDD:366222	105/321 (33%)
clp-4	NP_497460.2	Calpain_III	560..716	CDD:238132	42/163 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.970