DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and clp-3

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_493052.3	Gene:	clp-3 / 173089	WormBaseID:	WBGene00000544	Length:	752	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	146/509 - (28%)
Similarity:	241/509 - (47%)	Gaps:	81/509 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFL-NESAEFD 75
            |..:..|:|||.|||..||::....|.....|||        .|.:.||    |..: ::...||
Worm   259 CLDEKRLFEDPQFPANNSSIYVKVRPKDHIVWKR--------PGELFAN----PRLIGSDKTHFD 311

  Fly    76 VVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTI 139
            |..|::.:||.:|....||....|||||||.||:....: |:|.|:.|..||||:|::||||||:
Worm   312 VKLGRLENRWFLSGAANLSLRDELFYRVVPPDQSFTEKYAGIFHFQFWRYGEWVDVVIDDRLPTV 376

  Fly   140 NGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTD---------LLGGVVR---- 191
            ||.|.:|.....:.||..|||||.|||.|:||.|     :|..|:         ..||:.:
Worm   377 NGTLCYMSSPGGSEFWGPLLEKAYAKLLGTYEHL-----NDPYTEQALWQASASFTGGLTQWFDI 436

  Fly   192 ----QMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKV 252
                :|.:|:..:|...:..|      :.||   :..|.:|.:  |..||::....|.::.::.:
Worm   437 FMADEMAVLAMIMRGVQMGSL------IVCL---NIDVNEKGV--RQKNGLIKGYGYCITGVNLM 490

  Fly   253 KTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCD 317
            :| ..:...|:.::     .|:| |..:.||:...|..|..:.: |:....|....||||:|..|
Worm   491 ET-EWEKAPLIRIR-----SPWG-KVKWKGDFCYRSHRWFGLDK-EKRESFRIKEDGEFWMSLKD 547

  Fly   318 FVEIFSTMEVVYLDTETSNDEE------MLKSRPLHWKMKMHQGQWKRGV-TAGGCRNHESFHIN 375
            |:..|:.:....|..:|.::.|      :::.:...|.....:|:|...: |||||.:|::|..|
Worm   548 FMVEFTDVYCCNLSADTMHEVEKMTEVKVMEHQSQQWIQASFEGEWSSRIGTAGGCDDHDTFCTN 612

  Fly   376 PQLLISVQ--DEQD------LVIALNQ-------HTAVEPKVIGFTMYTWDGEYMLSECLQKDFF 425
            .|..|..:  |..|      ::.||.|       :..:|..:||..:|...|.   :|.:..:..
Worm   613 LQYEIHFRATDSYDSNHKCTIIAALFQKNRDHCVYKGLELFLIGLLVYEMPGP---NEKVTPEMV 674

  Fly   426 KNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSF 478
            |:.....:|. :.::|..:....:..||||::|:||:|.::..|.:||.....|
Worm   675 KSQTPIADSKLFKDSREANIRFTVPLGHYVIVPSTYDPDQDGEFLLRIFTNVDF 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	104/335 (31%)
		Calpain_III	346..483	CDD:238132	39/150 (26%)
		FRQ1	<567..648	CDD:227455
clp-3	NP_493052.3	MDN1	<5..136	CDD:227596
		CysPc	254..559	CDD:238004	104/335 (31%)
		Calpain_III	582..732	CDD:238132	39/150 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870