Protein Alignment CalpC and clp-3

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_493052.3
• Gene: clp-3 / 173089
• WormBaseID: WBGene00000544
• Length: 752
• Species: Caenorhabditis elegans
• Alignment Length: 509
• Identity: 146/509 - (28%)
• Similarity: 241/509 - (47%)
• Gaps: 81/509 - (15%)

  Fly    12 CRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFL-NESAEFD 75
            |..:..|:|||.|||..||::....|.....|||        .|.:.||    |..: ::...||
 Worm   259 CLDEKRLFEDPQFPANNSSIYVKVRPKDHIVWKR--------PGELFAN----PRLIGSDKTHFD 311

  Fly    76 VVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTI 139
            |..|::.:||.:|....||....|||||||.||:....: |:|.|:.|..||||:|::||||||:
 Worm   312 VKLGRLENRWFLSGAANLSLRDELFYRVVPPDQSFTEKYAGIFHFQFWRYGEWVDVVIDDRLPTV 376

  Fly   140 NGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTD---------LLGGVVR---- 191
            ||.|.:|.....:.||..|||||.|||.|:||.|     :|..|:         ..||:.:
 Worm   377 NGTLCYMSSPGGSEFWGPLLEKAYAKLLGTYEHL-----NDPYTEQALWQASASFTGGLTQWFDI 436

  Fly   192 ----QMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKV 252
                :|.:|:..:|...:..|      :.||   :..|.:|.:  |..||::....|.::.::.:
 Worm   437 FMADEMAVLAMIMRGVQMGSL------IVCL---NIDVNEKGV--RQKNGLIKGYGYCITGVNLM 490

  Fly   253 KTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCD 317
            :| ..:...|:.::     .|:| |..:.||:...|..|..:.: |:....|....||||:|..|
 Worm   491 ET-EWEKAPLIRIR-----SPWG-KVKWKGDFCYRSHRWFGLDK-EKRESFRIKEDGEFWMSLKD 547

  Fly   318 FVEIFSTMEVVYLDTETSNDEE------MLKSRPLHWKMKMHQGQWKRGV-TAGGCRNHESFHIN 375
            |:..|:.:....|..:|.::.|      :::.:...|.....:|:|...: |||||.:|::|..|
 Worm   548 FMVEFTDVYCCNLSADTMHEVEKMTEVKVMEHQSQQWIQASFEGEWSSRIGTAGGCDDHDTFCTN 612

  Fly   376 PQLLISVQ--DEQD------LVIALNQ-------HTAVEPKVIGFTMYTWDGEYMLSECLQKDFF 425
            .|..|..:  |..|      ::.||.|       :..:|..:||..:|...|.   :|.:..:..
 Worm   613 LQYEIHFRATDSYDSNHKCTIIAALFQKNRDHCVYKGLELFLIGLLVYEMPGP---NEKVTPEMV 674

  Fly   426 KNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSF 478
            |:.....:|. :.::|..:....:..||||::|:||:|.::..|.:||.....|
 Worm   675 KSQTPIADSKLFKDSREANIRFTVPLGHYVIVPSTYDPDQDGEFLLRIFTNVDF 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	104/335 (31%)
		Calpain_III	346..483	CDD:238132	39/150 (26%)
		EFh_PEF	515..680	CDD:355382
		EF-hand motif	515..543	CDD:320054
		EF-hand motif	556..585	CDD:320054
		EF-hand motif	586..615	CDD:320054
		EF-hand motif	622..650	CDD:320054
		EF-hand motif	652..680	CDD:320054
clp-3	NP_493052.3	MDN1	<7..>127	CDD:444083
		CysPc	254..559	CDD:238004	104/335 (31%)
		Calpain_III	582..732	CDD:238132	39/150 (26%)