DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn8

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_570960.2	Gene:	Capn8 / 170725	MGIID:	2181366	Length:	703	Species:	Mus musculus

Alignment Length:	714	Identity:	206/714 - (28%)
Similarity:	348/714 - (48%)	Gaps:	82/714 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQ-----WKRIMDLADSGSGAVAAN 60
            :...:|.:...|.:..||::||:|||..|::.|....|.:.:     |||..:|..:
Mouse    28 LGQDFETLRKQCLNSGVLFKDPEFPACPSALGYRDLGPGSAETQGIIWKRPTELCSN-------- 84

  Fly    61 SSAAPVFL-NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
                |.|: ..:...|:..|.:||.||::.:..|:....|.|||||.||:....: |:|.|:.|.
Mouse    85 ----PQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVVPRDQSFQKNYAGIFHFQFWQ 145

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||||::||||||.||:|.|:..:..|.||:||||||.|||:||||||..|:..:|..|..||
Mouse   146 YGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSYEALAGGSTIEGFEDFTGG 210

  Fly   189 V-----VRQMPILSDNIRPQTLKELLTTTCIVTCLADKS-ATVAKKNLAERMPNGILVNVNYRLS 247
            :     :|:.|   .|:. .|:::.|....::.|..|.| |..|:....:::..|..    |.::
Mouse   211 ISEFYDLRKPP---GNLY-YTIQKALRKGSLLGCSIDVSNAAEAEATTRQKLVKGHA----YSVT 267

  Fly   248 SLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFW 312
            .:::| ...|...:|:.|::     |:|| ..:.|.||..:..|..:...::..|.::...||||
Mouse   268 GVEEV-DFRGLPEKLIRLRN-----PWGE-VEWTGAWSDSAPEWNYIDPQKKGELDKRAEDGEFW 325

  Fly   313 LSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINP 376
            :||.||::.||.:|:..|..::.:.||:.|     |.:.:..|:|.||.|||||:|: .::..||
Mouse   326 MSFSDFLKQFSRLEICNLSPDSLSSEEIHK-----WNLVLFNGRWTRGSTAGGCQNYPATYWTNP 385

  Fly   377 QLLI---SVQDEQD---------LVIALNQHTAVEPK-------VIGFTMY--TWDGEYMLSECL 420
            |..|   .|.::|:         :::.|.|......:       .||:.:|  ..:.|....|.|
Mouse   386 QFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQRRIGQGMLSIGYAVYQIPKELENHTDEHL 450

  Fly   421 QKDFFK-NHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLE 484
            .:|||: ...|..:|.|.|.|.||....|..|.|:::|:|:||.::..|.:|:.  ...:...||
Mouse   451 GRDFFQGRQPSTCSSTYMNLREVSSRVQLPPGQYLVVPSTFEPFKDGDFCLRVF--SEKKAQALE 513

  Fly   485 TQTMILLDPF-PALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--ND 546
            ....:..||. |..:..|.|.         ..:..:..:.||::..|:..:|..:|...|.  .|
Mouse   514 IGDAVAGDPHEPHPRDMDGED---------EHFWSLSEEFADKDSEISAHQLKRVLNGLLSKRTD 569

  Fly   547 YIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDAL 611
            ......||:.||::|:|.|..|:|.:...:|||..:.:..:..:::.....:||.:.|..:|.||
Mouse   570 MKFDGFNINTCREMISLLDGDGTGSLRPVEFKTLWLKICKYLEIYQEMDHSRAGTIDAHEMRTAL 634

  Fly   612 CDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWI 675
            ...||.|:..:...:..||......:....||:.:|.|...|..|.|.:..|..::::.|.:|:
Mouse   635 KKAGFTLNNQVQQTIATRYACSKLGVDFDGFVACMIRLEILFKLFRLLDKDQNGIVQLSLAEWL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	110/334 (33%)
		Calpain_III	346..483	CDD:238132	44/159 (28%)
		FRQ1	<567..648	CDD:227455	18/80 (23%)
Capn8	NP_570960.2	Peptidase_C2	46..342	CDD:279042	107/322 (33%)
		Domain III	355..512		45/163 (28%)
		Calpain_III	356..509	CDD:279416	44/154 (29%)
		Linker. /evidence=ECO:0000250	513..531		4/17 (24%)
		Domain IV. /evidence=ECO:0000250	532..703		41/176 (23%)
		EFh	580..635	CDD:298682	15/54 (28%)
		PTZ00183	611..>692	CDD:185503	19/80 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920