Protein Alignment CalpC and LOC1280423

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_061515896.1
• Gene: LOC1280423 / 1280423
• VectorBaseID: AGAMI1_001723
• Length: 751
• Species: Anopheles gambiae
• Alignment Length: 717
• Identity: 181/717 - (25%)
• Similarity: 291/717 - (40%)
• Gaps: 140/717 - (19%)

  Fly    13 RSKNVLWEDPDFPAVQSSVFYYQTPPFTFQ------WKRIMDLADSGSGAVAANSSAAPVFLNES 71
            |....|.||.:||..          |.|..      |.|..|:.......:|  ....|:...|.
Mosquito    80 RGPGGLHEDLEFPPT----------PRTLSKKKQIVWMRPHDMCARPQFRIA--PPGTPLTAREL 132

  Fly    72 AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH---GVFRFRLWWCGEWVEVLVD 133
            .|    |...||..|::.||.||.|..|..||||.:||..:|:   |:|:||.|..|:|:||.||
Mosquito   133 PE----PVGPGDPSLLAALGCLSQLPRLLERVVPPEQTFDTANGYCGMFKFRFWQWGKWIEVRVD 193

  Fly   134 DRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQM----P 194
            |||||...|.|.|.....:.|||||||||.|||:|.|..|||||....|.||.|.||:.:    |
Mosquito   194 DRLPTRGDRPAHMHCAQPDIFWAALLEKAYAKLYGGYTFLKYGTVGRALQDLTGAVVQSVPPSGP 258

  Fly   195 ILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNL---AERMPNGILVNVNYRLSSLDKVKTLM 256
            :|...:...||                  .:|...|   .:|..:|:|....|.::.|.:|:...
Mosquito   259 LLGGAVPRSTL------------------LIAISGLEKETKRRRSGLLTEHPYCVTGLARVRANS 305

  Fly   257 GDS-----------VQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPG 309
            .||           ..|:.|:..:....:|..  :.|.||..|..|..:::.:|..| .|.....
Mosquito   306 NDSATHGSGSSGGDTSLIRLRSPWIGGEWGGV--WCGAWSERSWEWNALNERDRELLSSRSSNDC 368

  Fly   310 EFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFH 373
            |||:|..:|:..|..:.:.::..:....|..|.:| ..|:..:...||:.|..|||.... ::..
Mosquito   369 EFWMSVNEFLTRFVVIWLAHIGPDDWALEPGLHTR-APWRAALAVRQWRGGFNAGGPHKFIDTTA 432

  Fly   374 INPQLLISV----QDEQDLVIALNQ------HTAVEPKVIGFTMY-------TWDGEYMLSECLQ 421
            .|||..|.|    ..:..:|:|:.|      ....|.:.||||:|       ....:| :||.:.
Mosquito   433 TNPQFRIRVPPGHPSKAHVVVAVAQKYECYRSRNYEDEEIGFTIYEVPPGMQRVTPQY-VSEQMP 496

  Fly   422 KDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQ 486
            .||         :...|.|.::....|.||.:|::|...: ..|..|.:||.......:..:..:
Mosquito   497 LDF---------APLSNLREIATFFALPAGDFVVMPHAAQ-HREGRFLLRIFADQHTDVWEVNEE 551

  Fly   487 TMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEA---------- 541
            .::       :.:..||.|....:.:    ..:|...|.....|:..:|..:|:|
Mosquito   552 NLV-------IHNIAAEFCDERTIDA----RILYKLRARYPHEIDATQLQAILKAHGGNNRGFRG 605

  Fly   542 -----CLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGI 601
                 |.|        ::::||.::||:|.:..||::.:.....:..::.|:..|:......:|.
Mosquito   606 LGGINCGP--------SLELCRGMLALRDPALGGRLSIEHVPALIGLMRFWKAAFRRCGPSSSGT 662

  Fly   602 LRAER-----------LRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQ 655
            ....|           ||..|...|...|..::..|:.|:.| :..:.|..::.::..|..|..:
Mosquito   663 ATLSRGIWASKVSSYCLRGLLWAGGATASNKVLEALVSRFTR-NRQITLEGYLLSMARLHLAHER 726

  Fly   656 FH 657
            :|
Mosquito   727 YH 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	107/343 (31%)
		Calpain_III	346..483	CDD:238132	37/154 (24%)
		EFh_PEF	515..680	CDD:355382	31/169 (18%)
		EF-hand motif	515..543	CDD:320054	6/42 (14%)
		EF-hand motif	556..585	CDD:320054	7/28 (25%)
		EF-hand motif	586..615	CDD:320054	7/39 (18%)
		EF-hand motif	622..650	CDD:320054	4/27 (15%)
		EF-hand motif	652..680	CDD:320054	2/6 (33%)
LOC1280423	XP_061515896.1	None