Protein Alignment CalpC and Capn1

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_031626.1
• Gene: Capn1 / 12333
• MGIID: 88263
• Length: 713
• Species: Mus musculus
• Alignment Length: 715
• Identity: 203/715 - (28%)
• Similarity: 341/715 - (47%)
• Gaps: 83/715 - (11%)

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAAN 60
            :...||.:.:.|....||::|..||.|..|:.:.:..|     :..:|||..:|..:
Mouse    38 LGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSN-------- 94

  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
                |.|:.:.| ..|:..|.:||.||::.:..|:....:.:||||..|:....: |:|.|:||.
Mouse    95 ----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQ 155

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||:|::||.|||.:|:|.|:.....|.||:||||||.||::||||||..|..|:...|..||
Mouse   156 FGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGG 220

  Fly   189 V-----VRQMPILSDNIRPQTLK--ELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRL 246
            |     :::.|.....|..:.|:  .||..:..::.:.|..| :..|||..        ...|.:
Mouse   221 VTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEA-ITFKNLVR--------GHAYSV 276

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :...:| |..|..|.|:.:::     |:|| ..:.|.||..|..|.:|...||.:|..::..|||
Mouse   277 TGAKQV-TYQGQRVNLIRMRN-----PWGE-VEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEF 334

  Fly   312 WLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPL-HWKMKMHQGQWKRGVTAGGCRNH-ESFHI 374
            |:||.||:..|:.:|:..|..:.      ||||.| :|....::|.|:||.|||||||: .:|.:
Mouse   335 WMSFRDFIREFTKLEICNLTPDA------LKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWV 393

  Fly   375 NPQLLISVQDEQD-------------LVIALNQHTAVEPK------VIGFTMYTWDGEYMLSEC- 419
            |||..|.:::..|             |:..:.:|...|.:      .|||.:|....|......
Mouse   394 NPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVH 458

  Fly   420 LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCL 483
            |::|||..:.|...|: :.|.|.||....|..|.|:::|:|:||.:|..|.:|...........|
Mouse   459 LKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQEL 523

  Fly   484 ETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--ND 546
            :.|....|.....|...:.:.          .::.::.:||.::..|:..||..:|...:.  .|
Mouse   524 DDQIQANLPDEKVLSEEEIDD----------NFKTLFSKLAGDDMEISVKELQTILNRIISKHKD 578

  Fly   547 YIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDAL 611
            ......:::.||.::.|.||.|:|::...:|......::::..:|:.:..:|:|.:.|..:|.|:
Mouse   579 LRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAI 643

  Fly   612 CDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIK 676
            ...||:|:..:...:|.||...|..:...:||..::.|.|.|..|.|.:.....|:...|..|::
Mouse   644 EAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDLFKWLQ 708

  Fly   677  676
            Mouse   709  708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	107/335 (32%)
		Calpain_III	346..483	CDD:238132	47/159 (30%)
		EFh_PEF	515..680	CDD:355382	38/164 (23%)
		EF-hand motif	515..543	CDD:320054	6/27 (22%)
		EF-hand motif	556..585	CDD:320054	8/28 (29%)
		EF-hand motif	586..615	CDD:320054	6/28 (21%)
		EF-hand motif	622..650	CDD:320054	6/27 (22%)
		EF-hand motif	652..680	CDD:320054	6/25 (24%)
Capn1	NP_031626.1	Peptidase_C2	56..352	CDD:459889	104/323 (32%)
		Domain III	355..525		52/175 (30%)
		Calpain_III	366..523	CDD:238132	46/156 (29%)
		Linker	526..541		3/14 (21%)
		Domain IV	542..712		38/177 (21%)
		EFh_PEF_CAPN1	545..713	CDD:320073	38/164 (23%)
		EF-hand motif	545..573	CDD:320073	6/27 (22%)
		EF-hand motif	588..617	CDD:320073	8/28 (29%)
		EF-hand motif	618..648	CDD:320073	6/29 (21%)
		EF-hand motif	654..682	CDD:320073	6/27 (22%)
		EF-hand motif	684..713	CDD:320073	6/25 (24%)