DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpC and Capn1

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001103974.1	Gene:	Capn1 / 12333	MGIID:	88263	Length:	713	Species:	Mus musculus

Alignment Length:	715	Identity:	203/715 - (28%)
Similarity:	341/715 - (47%)	Gaps:	83/715 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAAN 60
            :...||.:.:.|....||::|..||.|..|:.:.:..|     :..:|||..:|..:
Mouse    38 LGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSN-------- 94

  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123
                |.|:.:.| ..|:..|.:||.||::.:..|:....:.:||||..|:....: |:|.|:||.
Mouse    95 ----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQ 155

  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188
            .||||:|::||.|||.:|:|.|:.....|.||:||||||.||::||||||..|..|:...|..||
Mouse   156 FGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGG 220

  Fly   189 V-----VRQMPILSDNIRPQTLK--ELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRL 246
            |     :::.|.....|..:.|:  .||..:..::.:.|..| :..|||..        ...|.:
Mouse   221 VTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEA-ITFKNLVR--------GHAYSV 276

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :...:| |..|..|.|:.:::     |:|| ..:.|.||..|..|.:|...||.:|..::..|||
Mouse   277 TGAKQV-TYQGQRVNLIRMRN-----PWGE-VEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEF 334

  Fly   312 WLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPL-HWKMKMHQGQWKRGVTAGGCRNH-ESFHI 374
            |:||.||:..|:.:|:..|..:.      ||||.| :|....::|.|:||.|||||||: .:|.:
Mouse   335 WMSFRDFIREFTKLEICNLTPDA------LKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWV 393

  Fly   375 NPQLLISVQDEQD-------------LVIALNQHTAVEPK------VIGFTMYTWDGEYMLSEC- 419
            |||..|.:::..|             |:..:.:|...|.:      .|||.:|....|......
Mouse   394 NPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVH 458

  Fly   420 LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCL 483
            |::|||..:.|...|: :.|.|.||....|..|.|:::|:|:||.:|..|.:|...........|
Mouse   459 LKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQEL 523

  Fly   484 ETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLP--ND 546
            :.|....|.....|...:.:.          .::.::.:||.::..|:..||..:|...:.  .|
Mouse   524 DDQIQANLPDEKVLSEEEIDD----------NFKTLFSKLAGDDMEISVKELQTILNRIISKHKD 578

  Fly   547 YIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDAL 611
            ......:::.||.::.|.||.|:|::...:|......::::..:|:.:..:|:|.:.|..:|.|:
Mouse   579 LRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAI 643

  Fly   612 CDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWIK 676
            ...||:|:..:...:|.||...|..:...:||..::.|.|.|..|.|.:.....|:...|..|::
Mouse   644 EAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDLFKWLQ 708

Fly 677 676
Mouse 709 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	107/335 (32%)
		Calpain_III	346..483	CDD:238132	47/159 (30%)
		FRQ1	<567..648	CDD:227455	18/80 (23%)
Capn1	NP_001103974.1	Peptidase_C2	56..352	CDD:279042	104/323 (32%)
		Domain III	355..525		52/175 (30%)
		Calpain_III	366..518	CDD:279416	46/151 (30%)
		Linker	526..541		3/14 (21%)
		PTZ00184	537..680	CDD:185504	31/152 (20%)
		Domain IV	542..712		38/177 (21%)
		EF-hand_8	556..609	CDD:290545	12/52 (23%)
		EFh	589..643	CDD:238008	13/53 (25%)
		EFh	622..704	CDD:298682	21/81 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920