DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and Capn9

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001258069.1	Gene:	Capn9 / 116694	RGDID:	70965	Length:	690	Species:	Rattus norvegicus

Alignment Length:	698	Identity:	219/698 - (31%)
Similarity:	345/698 - (49%)	Gaps:	69/698 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF-L 68
            :|::...|.....|:||.||||..||:||.:.|...|.|||        .|.:..|    |.| |
  Rat    29 FEQLRQSCLQSGTLFEDADFPASNSSLFYSERPQVPFVWKR--------PGEIVEN----PEFIL 81

  Fly    69 NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132
            ..:...|:..|::||.||::.:..|:..:....||||.||...|.: |:|.|:.|...||::|::
  Rat    82 GGATRTDICQGELGDCWLLAAIASLTLNQKALARVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVI 146

  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILS 197
            ||||||...||.|:.....|.||:||||||.|||:|||||||.|:..:.:.|..|||.....|..
  Rat   147 DDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIRE 211

  Fly   198 DNIRPQTLKELLTTT----CIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGD 258
               .|:...|:|...    .::.|..|   |:.......|.|.|::....|.::.||:| ...|.
  Rat   212 ---APEDFYEILEKALRRGSLLGCSID---TLNASESEARTPLGLIKGHAYTVTGLDQV-NFHGQ 269

  Fly   259 SVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVEIF 322
            .::|:.:::     |:|: ..:.|.||..|..|..:|..|:.|| ...|..||||::|.||...|
  Rat   270 RIKLIRVRN-----PWGQ-VEWNGPWSDSSPEWRSMSLEEQKRLGHTALDDGEFWMAFEDFKTHF 328

  Fly   323 STMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQDEQ 386
            ..:|:..|..:...|..:.|     |::.:|||.|.||.|||||||. ::|..|||:.:|:.:..
  Rat   329 DKVEICNLTPDALEDNTLHK-----WEVTIHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTERD 388

  Fly   387 D------LVIALNQHTAVEPKVIGFTMYTWDGEYMLSEC------LQKDFFKNHVSYLNS-DYGN 438
            :      .:.||.|......|..|..|.|..  |.:.:|      |.:|||:.|.|...| .:.|
  Rat   389 EGQEGCTFLAALMQKDRRRLKRFGANMLTIG--YAIYQCPDKDGHLNRDFFRYHASLARSKTFIN 451

  Fly   439 TRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMI----LLDPFPALKS 499
            .|.||....|..|.|:|||:|:||.:||.|.:||..........|:....|    |..|.|..:.
  Rat   452 LREVSGRFQLPPGDYILIPSTFEPHQEADFCLRIFSEKKAVTQDLDENIDIDLPELPKPTPQEEE 516

  Fly   500 TDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYIKGCANIDI--CRQVIA 562
            |:.||          |:..::.::|.|:..::..||..:|.|.|..........:.:  ||.:|:
  Rat   517 TEEER----------QFRALFRRIAGEDMEVSAEELEYVLNAVLQKKTALKFKRLSLLSCRNIIS 571

  Fly   563 LQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLI 627
            |.|.||:|::.|::|:.|...|:.|..:|..:..:|:|.:.:..||.||...||||.:.::..::
  Rat   572 LMDTSGNGKMEFEEFRVFWDKLRYWMDLFLQFDVDKSGTMSSYELRTALKAAGFQLGSHLLQLIV 636

  Fly   628 QRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWI 675
            .||..::..|...|:::.::.|..|...|...:....:.|.::::::|
  Rat   637 LRYADENLQLDFDDYLNCLVRLENASRVFQCLSVKNKDFIHLNINEFI 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	113/328 (34%)
		Calpain_III	346..483	CDD:238132	53/150 (35%)
		FRQ1	<567..648	CDD:227455	23/80 (29%)
Capn9	NP_001258069.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Peptidase_C2	43..335	CDD:279042	111/316 (35%)
		Domain III	338..521		61/189 (32%)
		Calpain_III	349..491	CDD:279416	53/143 (37%)
		Domain IV	522..690		41/163 (25%)
		EFh	566..621	CDD:238008	19/54 (35%)
		EF-hand_7	597..652	CDD:290234	15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920