Protein Alignment CalpC and Capn9

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001258069.1
• Gene: Capn9 / 116694
• RGDID: 70965
• Length: 690
• Species: Rattus norvegicus
• Alignment Length: 698
• Identity: 219/698 - (31%)
• Similarity: 345/698 - (49%)
• Gaps: 69/698 - (9%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF-L 68
            :|::...|.....|:||.||||..||:||.:.|...|.|||        .|.:..|    |.| |
  Rat    29 FEQLRQSCLQSGTLFEDADFPASNSSLFYSERPQVPFVWKR--------PGEIVEN----PEFIL 81

  Fly    69 NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132
            ..:...|:..|::||.||::.:..|:..:....||||.||...|.: |:|.|:.|...||::|::
  Rat    82 GGATRTDICQGELGDCWLLAAIASLTLNQKALARVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVI 146

  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILS 197
            ||||||...||.|:.....|.||:||||||.|||:|||||||.|:..:.:.|..|||.....|..
  Rat   147 DDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIRE 211

  Fly   198 DNIRPQTLKELLTTT----CIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGD 258
               .|:...|:|...    .::.|..|   |:.......|.|.|::....|.::.||:| ...|.
  Rat   212 ---APEDFYEILEKALRRGSLLGCSID---TLNASESEARTPLGLIKGHAYTVTGLDQV-NFHGQ 269

  Fly   259 SVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVEIF 322
            .::|:.:::     |:|: ..:.|.||..|..|..:|..|:.|| ...|..||||::|.||...|
  Rat   270 RIKLIRVRN-----PWGQ-VEWNGPWSDSSPEWRSMSLEEQKRLGHTALDDGEFWMAFEDFKTHF 328

  Fly   323 STMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQDEQ 386
            ..:|:..|..:...|..:.|     |::.:|||.|.||.|||||||. ::|..|||:.:|:.:..
  Rat   329 DKVEICNLTPDALEDNTLHK-----WEVTIHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTERD 388

  Fly   387 D------LVIALNQHTAVEPKVIGFTMYTWDGEYMLSEC------LQKDFFKNHVSYLNS-DYGN 438
            :      .:.||.|......|..|..|.|..  |.:.:|      |.:|||:.|.|...| .:.|
  Rat   389 EGQEGCTFLAALMQKDRRRLKRFGANMLTIG--YAIYQCPDKDGHLNRDFFRYHASLARSKTFIN 451

  Fly   439 TRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMI----LLDPFPALKS 499
            .|.||....|..|.|:|||:|:||.:||.|.:||..........|:....|    |..|.|..:.
  Rat   452 LREVSGRFQLPPGDYILIPSTFEPHQEADFCLRIFSEKKAVTQDLDENIDIDLPELPKPTPQEEE 516

  Fly   500 TDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYIKGCANIDI--CRQVIA 562
            |:.||          |:..::.::|.|:..::..||..:|.|.|..........:.:  ||.:|:
  Rat   517 TEEER----------QFRALFRRIAGEDMEVSAEELEYVLNAVLQKKTALKFKRLSLLSCRNIIS 571

  Fly   563 LQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLI 627
            |.|.||:|::.|::|:.|...|:.|..:|..:..:|:|.:.:..||.||...||||.:.::..::
  Rat   572 LMDTSGNGKMEFEEFRVFWDKLRYWMDLFLQFDVDKSGTMSSYELRTALKAAGFQLGSHLLQLIV 636

  Fly   628 QRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHDWI 675
            .||..::..|...|:::.::.|..|...|...:....:.|.::::::|
  Rat   637 LRYADENLQLDFDDYLNCLVRLENASRVFQCLSVKNKDFIHLNINEFI 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	113/328 (34%)
		Calpain_III	346..483	CDD:238132	53/150 (35%)
		EFh_PEF	515..680	CDD:355382	41/163 (25%)
		EF-hand motif	515..543	CDD:320054	7/27 (26%)
		EF-hand motif	556..585	CDD:320054	11/30 (37%)
		EF-hand motif	586..615	CDD:320054	8/28 (29%)
		EF-hand motif	622..650	CDD:320054	4/27 (15%)
		EF-hand motif	652..680	CDD:320054	4/24 (17%)
Capn9	NP_001258069.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		Peptidase_C2	43..335	CDD:459889	111/316 (35%)
		Domain III	338..521		61/189 (32%)
		Calpain_III	347..496	CDD:238132	54/155 (35%)
		Domain IV	522..690		41/163 (25%)
		EFh_PEF	522..690	CDD:355382	41/163 (25%)
		EF-hand motif	522..550	CDD:320054	7/27 (26%)
		EF-hand motif	565..594	CDD:320054	11/28 (39%)
		EF-hand motif	595..624	CDD:320054	8/28 (29%)
		EF-hand motif	631..659	CDD:320054	4/27 (15%)
		EF-hand motif	661..689	CDD:320054	4/24 (17%)