Protein Alignment CalpC and CAPN10

DIOPT Version :9

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_075571.2
• Gene: CAPN10 / 11132
• HGNCID: 1477
• Length: 672
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 155/605 - (25%)
• Similarity: 240/605 - (39%)
• Gaps: 124/605 - (20%)

  Fly    18 LWEDPDFPAVQSSVFY-YQTPPFTFQ----WKRIMDLADSGSGAVAANSSAAP-VFLNESAEFDV 76
            |:.|..|||..||:|. ..||...|:    |:|..::.            |.| :|.::..|..|
Human    13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEIC------------ATPRLFPDDPREGQV 65

  Fly    77 VPGKMGDRWLVSCLGLLSSLRNLFYRVVP------ADQTLASAHGVFRFRLWWCGEWVEVLVDDR 135
            ..|.:||.|.:.....|...|:|..:|:|      |||   ...|.|..|:|..|.||||..|||
Human    66 KQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQ---EYRGSFTCRIWQFGRWVEVTTDDR 127

  Fly   136 LPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPIL---- 196
            ||.:.|||.|.:.|..:.||..||||..||:|||||.|..|..:|.|.||.||:..:..:.
Human   128 LPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

  Fly   197 --SDNIRP-----QTLKEL--LTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKV 252
              ....||     :|.::|  |...|:::|.. .|.....:.|.|           :....:..:
Human   193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCV-LSPRAGARELGE-----------FHAFIVSDL 245

  Fly   253 KTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWLSFCD 317
            :.|.|.:.|.:.|...  ..|:|.:. :.|.|....:.|.:|.....:.|:.||..||||:...:
Human   246 RELQGQAGQCILLLRI--QNPWGRRC-WQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEE 307

  Fly   318 FVEIFSTMEVVYLDTETSNDEEMLKSRPL-HWKMKMHQGQWKRGVTAGGCRNHESFHINPQLLIS 381
            |:..|..:.|.|..||..:.:.:...|.| |  .:...|.|.:|.:||||||:..|..||:..:.
Human   308 FLREFDELTVGYPVTEAGHLQSLYTERLLCH--TRALPGAWVKGQSAGGCRNNSGFPSNPKFWLR 370

  Fly   382 VQDEQDLVIALNQ--------------------HTAVEP--------KVIGFTMYTWDGEYMLSE 418
            |.:..::.||:.|                    ||:..|        :.:|  ::.|..|
Human   371 VSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVG--LHLWKVE----- 428

  Fly   419 CLQKDFFKNHVSYL----------NSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRIL 473
                   |..|:..          .:.:...|.|.....|..|:|:.:|:|:.......|.:|:.
Human   429 -------KRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVF 486

  Fly   474 GTGSFRLSCLETQTMILLDPFPALKSTD------------AERCGGPKVKSVCQYEPVYMQLADE 526
            .||...||.:..... ...|..||.:.:            .:..||.:..:.....|.:.....|
Human   487 STGRVSLSAIRAVAK-NTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPE 550

  Fly   527 NKTINCFELHELLEACLPND 546
            .....|..: .|.:.|.|:|
Human   551 GPGPRCVRI-TLHQHCRPSD 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	100/335 (30%)
		Calpain_III	346..483	CDD:238132	39/175 (22%)
		FRQ1	<567..648	CDD:227455
CAPN10	NP_075571.2	CysPc	2..319	CDD:238004	100/335 (30%)
		Domain III 1	322..494		40/187 (21%)
		Calpain_III	335..496	CDD:238132	39/176 (22%)
		Calpain_III	512..653	CDD:238132	9/59 (15%)
		Domain III 2	513..654		9/58 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880