DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn8.3

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_031758475.1	Gene:	capn8.3 / 100498169	XenbaseID:	XB-GENE-18006552	Length:	700	Species:	Xenopus tropicalis

Alignment Length:	722	Identity:	208/722 - (28%)
Similarity:	344/722 - (47%)	Gaps:	109/722 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69
            |.::.:.|.:.|.|:||..|||.|:|:...:..|.:.:.|.|:.|              .|:.::
Frog    32 YGQLKAQCLASNSLFEDEPFPASQASLGVKELGPDSDKTKGIVWL--------------RPMQIH 82

  Fly    70 ESAEF--------DVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCG 125
            ...||        |:..|.:||.|.:|.:..|:.......:|||.||:..:.: |:|.|:.|..|
Frog    83 PKPEFIISGATRSDIRQGSLGDCWFLSSIASLTLNEEYLSQVVPGDQSFQTNYAGIFHFKFWQYG 147

  Fly   126 EWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVV 190
            |||:|:|||||||..|:|.|::....|.||:||||||.|||:||||||..|:..|.|.|..||:.
Frog   148 EWVDVVVDDRLPTKKGKLVFVKSAEGNEFWSALLEKAYAKLNGSYEALIGGSPVDALEDFTGGIA 212

  Fly   191 RQMPILSDNIRP-----QTLKELLTTTCIVTCL----ADKSATVAKKNLAERMPNGILVNVNYRL 246
             ::..|.   :|     |.::::|....::||.    :.|..||||        |.::.|..|.:
Frog   213 -ELYYLE---KPPADLFQRVQKVLRANSLLTCSSKSDSGKVETVAK--------NNVVKNHAYTI 265

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :..::| :..|:.|||:.|::     |:| ||.:.|.||..:..|:.:....||.|..|...||.
Frog   266 TRAEEV-SYRGEKVQLIRLRN-----PWG-KTEWNGAWSDNAPEWDDIDSETRAALNTQGDDGEV 323

  Fly   312 WLSFCDFVEIFSTMEV--VYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFH 373
            |:.|.||:..|..:::  :.||...|.:|.       .|.:....|.||.|.|||||:.: ::|.
Frog   324 WMPFSDFISEFYRLDICNLSLDCVCSKEER-------RWCLTQFYGSWKSGCTAGGCKKYPDTFW 381

  Fly   374 INPQLLISVQDEQD-----------LVIALNQH-------TAVEPKVIGFTMYTWDGEYMLSE-- 418
            ||||..|.:::..|           :::||.|.       |..|...:|:.:|....|...|.
Frog   382 INPQFRIKLEEPDDERGAGKAQSCTVIVALIQKNRRKMKPTGGEEFAVGYYLYPIPKELQGSPDV 446

  Fly   419 CLQKDFF--KNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILG---TGSF 478
            .|.||||  ..:|::.:. |...|.......|..|.|||:|.||.|.:||.|.:|:..   .|.:
Frog   447 PLGKDFFLKTKYVAWTDV-YKKHRETCCRHKLPVGEYVLLPHTYYPCQEADFCLRVFSEKKVGVW 510

  Fly   479 RLSCLETQTMILLDPFPALKSTDAERCGGPKVKS-----VCQYEPVYMQLADENKTINCFELHEL 538
            .|..:....:..||      .:|.:      |:|     :.:.|...|:::.|...||   |..:
Frog   511 ELGDVANADLYQLD------VSDIQ------VESEIGDILTELEQQKMEMSAEELRIN---LSRI 560

  Fly   539 LEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILR 603
            |..  ..|......::..|:::|.|.|...:|::::::|:...:.|..:..:||....:::..:.
Frog   561 LSK--RKDIKSDGFSLTTCKEMINLFDTDLTGKLSYKEFRPLWIKLVKYTKIFKSADNDRSESIE 623

  Fly   604 AERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIE 668
            |..:|:||...||.|:..|...::||||....::....|::.:|.|.|.|..|.|....:...:.
Frog   624 AHEMRNALQQAGFNLNNKIQEAIVQRYITNGLSISFDSFIACLIRLETLFKMFELLKTNENGALS 688

  Fly   669 VHLHDWI 675
            :.|.:|:
Frog   689 LSLSEWL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	111/341 (33%)
		Calpain_III	346..483	CDD:238132	49/162 (30%)
		FRQ1	<567..648	CDD:227455	18/80 (23%)
capn8.3	XP_031758475.1	Peptidase_C2	46..341	CDD:395523	108/327 (33%)
		Calpain_III	362..502	CDD:395848	46/140 (33%)
		EFh_PEF	533..700	CDD:355382	38/168 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010