Protein Alignment CalpC and capn8.3

DIOPT Version :10

• Sequence 1: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_031758475.1
• Gene: capn8.3 / 100498169
• XenbaseID: XB-GENE-18006552
• Length: 700
• Species: Xenopus tropicalis
• Alignment Length: 722
• Identity: 208/722 - (28%)
• Similarity: 344/722 - (47%)
• Gaps: 109/722 - (15%)

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69
            |.::.:.|.:.|.|:||..|||.|:|:...:..|.:.:.|.|:.|              .|:.::
 Frog    32 YGQLKAQCLASNSLFEDEPFPASQASLGVKELGPDSDKTKGIVWL--------------RPMQIH 82

  Fly    70 ESAEF--------DVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCG 125
            ...||        |:..|.:||.|.:|.:..|:.......:|||.||:..:.: |:|.|:.|..|
 Frog    83 PKPEFIISGATRSDIRQGSLGDCWFLSSIASLTLNEEYLSQVVPGDQSFQTNYAGIFHFKFWQYG 147

  Fly   126 EWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVV 190
            |||:|:|||||||..|:|.|::....|.||:||||||.|||:||||||..|:..|.|.|..||:.
 Frog   148 EWVDVVVDDRLPTKKGKLVFVKSAEGNEFWSALLEKAYAKLNGSYEALIGGSPVDALEDFTGGIA 212

  Fly   191 RQMPILSDNIRP-----QTLKELLTTTCIVTCL----ADKSATVAKKNLAERMPNGILVNVNYRL 246
             ::..|.   :|     |.::::|....::||.    :.|..||||        |.::.|..|.:
 Frog   213 -ELYYLE---KPPADLFQRVQKVLRANSLLTCSSKSDSGKVETVAK--------NNVVKNHAYTI 265

  Fly   247 SSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEF 311
            :..::| :..|:.|||:.|::     |:| ||.:.|.||..:..|:.:....||.|..|...||.
 Frog   266 TRAEEV-SYRGEKVQLIRLRN-----PWG-KTEWNGAWSDNAPEWDDIDSETRAALNTQGDDGEV 323

  Fly   312 WLSFCDFVEIFSTMEV--VYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFH 373
            |:.|.||:..|..:::  :.||...|.:|.       .|.:....|.||.|.|||||:.: ::|.
 Frog   324 WMPFSDFISEFYRLDICNLSLDCVCSKEER-------RWCLTQFYGSWKSGCTAGGCKKYPDTFW 381

  Fly   374 INPQLLISVQDEQD-----------LVIALNQH-------TAVEPKVIGFTMYTWDGEYMLSE-- 418
            ||||..|.:::..|           :::||.|.       |..|...:|:.:|....|...|.
 Frog   382 INPQFRIKLEEPDDERGAGKAQSCTVIVALIQKNRRKMKPTGGEEFAVGYYLYPIPKELQGSPDV 446

  Fly   419 CLQKDFF--KNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILG---TGSF 478
            .|.||||  ..:|::.:. |...|.......|..|.|||:|.||.|.:||.|.:|:..   .|.:
 Frog   447 PLGKDFFLKTKYVAWTDV-YKKHRETCCRHKLPVGEYVLLPHTYYPCQEADFCLRVFSEKKVGVW 510

  Fly   479 RLSCLETQTMILLDPFPALKSTDAERCGGPKVKS-----VCQYEPVYMQLADENKTINCFELHEL 538
            .|..:....:..||      .:|.:      |:|     :.:.|...|:::.|...||   |..:
 Frog   511 ELGDVANADLYQLD------VSDIQ------VESEIGDILTELEQQKMEMSAEELRIN---LSRI 560

  Fly   539 LEACLPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILR 603
            |..  ..|......::..|:::|.|.|...:|::::::|:...:.|..:..:||....:::..:.
 Frog   561 LSK--RKDIKSDGFSLTTCKEMINLFDTDLTGKLSYKEFRPLWIKLVKYTKIFKSADNDRSESIE 623

  Fly   604 AERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIE 668
            |..:|:||...||.|:..|...::||||....::....|::.:|.|.|.|..|.|....:...:.
 Frog   624 AHEMRNALQQAGFNLNNKIQEAIVQRYITNGLSISFDSFIACLIRLETLFKMFELLKTNENGALS 688

  Fly   669 VHLHDWI 675
            :.|.:|:
 Frog   689 LSLSEWL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	111/341 (33%)
		Calpain_III	346..483	CDD:238132	49/162 (30%)
		EFh_PEF	515..680	CDD:355382	38/161 (24%)
		EF-hand motif	515..543	CDD:320054	7/27 (26%)
		EF-hand motif	556..585	CDD:320054	6/28 (21%)
		EF-hand motif	586..615	CDD:320054	6/28 (21%)
		EF-hand motif	622..650	CDD:320054	7/27 (26%)
		EF-hand motif	652..680	CDD:320054	5/24 (21%)
capn8.3	XP_031758475.1	Peptidase_C2	46..341	CDD:459889	108/327 (33%)
		Calpain_III	360..502	CDD:460050	46/142 (32%)
		EFh_PEF	533..700	CDD:355382	38/168 (23%)
		EF-hand motif	533..561	CDD:320054	6/30 (20%)
		EF-hand motif	576..605	CDD:320054	6/28 (21%)
		EF-hand motif	606..635	CDD:320054	6/28 (21%)
		EF-hand motif	642..670	CDD:320054	7/27 (26%)
		EF-hand motif	672..700	CDD:320054	5/24 (21%)