DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn10l

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_031758129.1	Gene:	capn10l / 100497805	XenbaseID:	XB-GENE-5889689	Length:	708	Species:	Xenopus tropicalis

Alignment Length:	724	Identity:	175/724 - (24%)
Similarity:	320/724 - (44%)	Gaps:	111/724 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KNVLWEDPDFPAVQSSVFYYQTPPF---TFQWKRIMDLADSGSGAVAANSSAAPVFLNESAE-FD 75
            |.||:.|.:|||....:..:....|   ..:|:|..:...:            |..:.:.|. ||
Frog    39 KGVLFNDEEFPADMRVIGPHLIDEFKIHNMEWRRPPEFCKN------------PHLIVDGASYFD 91

  Fly    76 VVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTI 139
            :|..|:||.|::|.:|.::..:.|...::||||.....: |:|.||.|:.|:||:|::|||||.:
Frog    92 IVQSKIGDCWVLSTIGSVTQKQTLLRNIIPADQGFTRNYAGIFHFRFWYSGKWVDVVIDDRLPFL 156

  Fly   140 NGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNIRPQT 204
            ||....::...:..:|..|||||.|||.|||:.|.:|..::.|.:..|.:...:.:...::....
Frog   157 NGDFFSVRASCAKEYWPCLLEKAYAKLLGSYQNLHWGDPAEALVNFTGALTLTLKLKGGDLHHSD 221

  Fly   205 LKELL---TTTCIVTCLADKSATVAKKNLAERMP---------------NGILVNVNYRLSSLDK 251
            :.|::   :...::||:::| |.|...|....:|               |..:.|::.....:|:
Frog   222 IWEMVHKSSQKALITCISEK-AEVMTHNRRYSVPSAMEGRDERRRSDPANKYIENIHVDNGLVDR 285

  Fly   252 VKTLMGDSVQLV---CLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLGPGEFWL 313
            ....:.|:.|:.   |:.......|:| :..::|.||.....|..:...:|.:|..:...||||:
Frog   286 HAYTVTDTAQVYREGCVNLIRLWNPWG-RGEWIGRWSDNCSWWNDIDPEDRKKLNTKREDGEFWM 349

  Fly   314 SFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHESFHINPQL 378
            |:..||:.||.:.:.....:..|.....:|    |....::..|.:........|.:.|..|||.
Frog   350 SWETFVQQFSRVIICSPTLDFLNWGRDQRS----WHKTSYENIWPKASGLEDSFNKDLFCKNPQY 410

  Fly   379 LI------SVQDEQDLVIALNQHTAVEPKV------IGFTMYTWDGEYMLSECLQK---DFFKNH 428
            ||      .||...:::|:|.|:.....|.      |||.:...|.|  |.:..:|   .||...
Frog   411 LIRISPSDEVQKGYNVIISLMQNHRNRQKFGRGWLPIGFLVSKVDAE--LPDPQRKMPGSFFLKD 473

  Fly   429 VS---YLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQ--TM 488
            :.   ::|..    |.|:....|.:|.||:.|...:.::|:.|.:::.         |.:|  |:
Frog   474 LQSGIHINKQ----RDVTKGLKLASGRYVITPFNADRSQESSFLLQVF---------LRSQGCTV 525

  Fly   489 ILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEACLPNDYI-KGCA 552
            .|.|....||:.:..:            |..:|:.|.:...:|..:|.:.|     ||.| ||.|
Frog   526 ELGDSQSFLKNEEKTQ------------EETFMKYATQGGKMNSQDLQKFL-----NDVISKGFA 573

  Fly   553 -------NIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLRDA 610
                   :.:..|.::|..|.:.:|::..:.|......|..::.:|.....::.|.:....||.|
Frog   574 PHGGIRFSTEASRSMLASMDFTCNGKLELEFFMRLWRYLNHFKAIFTDVDVDQNGFIGLSELRKA 638

  Fly   611 LCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFH-LKNYGQVNVIEVHLHD- 673
            ....|..:|:|.:..|:.||...:..|...|::..::.|.:||.:|. |.:.|:    .|:|.:
Frog   639 AKSAGMAVSSDQLTILLLRYGDYEMKLNFEDYLCCMVRLKSAFKRFQMLTSDGK----GVYLTEG 699

  Fly   674 -WIKSILSC 681
             |:|.::||
Frog   700 KWLKIMMSC 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	89/339 (26%)
		Calpain_III	346..483	CDD:238132	34/154 (22%)
		FRQ1	<567..648	CDD:227455	16/80 (20%)
capn10l	XP_031758129.1	Peptidase_C2	43..365	CDD:395523	86/335 (26%)
		Calpain_III	400..517	CDD:395848	32/122 (26%)
		EFh_PEF_CAPN13_14	541..708	CDD:320070	41/187 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020