DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn3

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_002935381.2	Gene:	capn3 / 100497532	XenbaseID:	XB-GENE-5875739	Length:	805	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	214/783 - (27%)
Similarity:	359/783 - (45%)	Gaps:	145/783 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVF-L 68
            :|.:...|..:|..::|.:||..:||:||.|:.|..|:|||..::.::            |.| |
Frog    52 FEELRKKCLQRNFHFQDREFPPDESSLFYSQSFPIKFEWKRPPEICEN------------PQFIL 104

  Fly    69 NESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132
            ..:...|:..|.:||.|.::.:..|:....:.:||:|.||.....: |:|.|:.|..|:||:|::
Frog   105 GGANRTDICQGDLGDCWFLAAIACLTLNEKVLFRVIPPDQNFTDNYAGIFHFQFWRYGDWVDVII 169

  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV-----VRQ 192
            ||.|||.|..|.|.:....|.||:||||||.|||||||||||.|..::.:.|..|||     :::
Frog   170 DDYLPTYNNELVFTKSSQRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFYELKE 234

  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLADKS----------------------------------- 222
            .|....||    :|:......::.|..|..
Frog   235 APKDMYNI----MKKAFERGSLIGCSIDDKYGSSCGFAPPSNMEDAIMKMIESVGDTRPDTNGRG 295

  Fly   223 ------ATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFL 281
                  ||:....|..||.||::....|.::.:::.| |.|..::||.|::     |:|: ..:.
Frog   296 QPPKPVATLVPVQLETRMANGLVKGHAYSVTGVEETK-LKGKPIKLVRLRN-----PWGQ-VEWN 353

  Fly   282 GDWSPMSKTWERVSQVERARLIRQL-GPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRP 345
            |.|...:|.|..|.:.|:.||..|: ..||||:|:.||::.|:..|:..| |..:.|.:.|:.
Frog   354 GAWGDNAKEWTMVDKSEKTRLQHQVQEDGEFWMSYDDFMKNFTKAEICNL-TPDALDSDSLQV-- 415

  Fly   346 LHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQDEQD----------LVIALNQHTAVE 399
              |.:.:::|:|.||.:||||||: :::..|||..:.:.:|.|          .|:||.|....:
Frog   416 --WTVSVNEGRWVRGCSAGGCRNYPDTYWTNPQYRLKLLEEDDDPADNEVVCSFVVALMQKNRRK 478

  Fly   400 PK-------VIGFTMYTWDGE-YMLSECLQKDFFKNHVSYLN-SDYGNTRHVSYHTHLEAGHYVL 455
            .:       .|||.:|....| :..::.||||||..:.|... ..|.|.|.|.....|....||:
Frog   479 DRKAGANLFTIGFAIYEVPKEMHGNNQHLQKDFFLYNASKAKCKSYINMREVCQRFRLPPSEYVI 543

  Fly   456 IPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLD--------PFPAL--------------- 497
            ||:||||.:|..|.:|:.  ...|....|.:..|..:        |.|.:
Frog   544 IPSTYEPHQEGEFILRVF--SEKRNISEEVENKIEAEKPIKKKKKPKPIIFVSDRSNSNKELNVD 606

  Fly   498 -------KSTDAERCGGPKVKSVC----------QYEPVYMQLADENKTINCFELHELLEACL-P 544
                   |..|||:    |.|:..          |:..::.|:|.::..|:..||..:|...: .
Frog   607 GATDEDQKKMDAEK----KDKTSASTDTETEEEKQFRNIFQQIAGDDMEISADELQSVLNNVVNK 667

  Fly   545 NDYIKGCA-NIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRAERLR 608
            :..:|... .::.||.:|||.|..|.||:..|:|......:|.||.:|..:..:::|.:.:..:|
Frog   668 HKTLKSSGFTLESCRSMIALMDTDGCGRLNLQEFYHLWQKIKQWQKIFLRFDSDQSGTISSFEMR 732

  Fly   609 DALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEVHLHD 673
            :|:.:.||.|:..:.:.:..||..|...|....|:...:.|...|..||..:.....:|::::.:
Frog   733 NAINEAGFHLNNQLYDIITMRYANKRMDLDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE 797

  Fly   674 WIK 676
            |::
Frog   798 WLQ 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	110/370 (30%)
		Calpain_III	346..483	CDD:238132	49/156 (31%)
		FRQ1	<567..648	CDD:227455	20/80 (25%)
capn3	XP_002935381.2	Peptidase_C2	66..402	CDD:279042	108/358 (30%)
		Calpain_III	416..566	CDD:279416	48/151 (32%)
		Calpain_u2	570..637	CDD:293254	10/70 (14%)
		EFh	648..706	CDD:298682	16/57 (28%)
		EFh	681..735	CDD:238008	17/53 (32%)
		EFh	712..801	CDD:298682	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020