DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn8.5

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_002939795.1	Gene:	capn8.5 / 100379861	XenbaseID:	XB-GENE-22164422	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	508	Identity:	142/508 - (27%)
Similarity:	233/508 - (45%)	Gaps:	106/508 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAA----- 64
            ||::.:.|.:.|.|:||..|||.|:|:                     ||..:...||.|
Frog    19 YEQLKAQCLASNTLFEDEKFPAGQASL---------------------GSNKMGPESSKAKGIVW 62

  Fly    65 --PVFLNESAE--------FDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFR 118
              |:.:|.:||        ||:....:.|...:|.:|..:........|:|.||...:.: |:|.
Frog    63 MRPLEINPNAEFITDGATRFDICQSTIADCGFLSTIGCATLSEEYLSLVLPQDQNFKTNYAGIFH 127

  Fly   119 FRLWWCGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLT 183
            |:.|..|||::|:|||:|||.:.:|.|::....|.||.||||||.|||.||||||:|...:..|.
Frog   128 FKFWQRGEWLDVVVDDKLPTRDKKLVFVKSAEENEFWPALLEKAFAKLRGSYEALEYQYSTVALQ 192

  Fly   184 DLLGGVV-------RQMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVN 241
            ...|||.       .|.|         .::..:.:.|::|  :...|....|||        :..
Frog   193 HFTGGVCLWYFLKKHQFP---------KIQRAVKSKCLLT--SSTGAFTHDKNL--------VAA 238

  Fly   242 VNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQL 306
            .:|.::..::| :..|:.||||.|::     |:|.| .:.|.||..:..|..|:|..:..|:.|.
Frog   239 HSYSITGAEEV-SYKGEKVQLVRLRN-----PWGYK-EWTGAWSDNAPEWNDVAQEVKDALLTQK 296

  Fly   307 GPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHES 371
            ..||||:.|.|.|:.:.::::.::    :..:|:....| ||.:...:|.||:|.:|      |.
Frog   297 DDGEFWIPFLDMVKDYESLDICHI----APSKEVNVEEP-HWSLMQTEGSWKKGDSA------ER 350

  Fly   372 FHINPQLLISVQ-----DEQD---------LVIALNQHTAVEPKVIGFTMYTWDGEYMLSECLQK 422
            |..:||..|.::     |:||         :::||.....:| ||..|.:|....| :.:..|.|
Frog   351 FLADPQFRIKLEVPDDDDDQDAAEDKALCTVIVALMSKEILE-KVPDFLLYQLPKE-VPTNLLVK 413

  Fly   423 D---FFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRI 472
            |   ..:..|:..|.:|.....|      :.|.|.:||...:|.::..|.:|:
Frog   414 DLKAMARERVNNRNKEYVGCFQV------QKGEYAVIPNPSDPNQDFDFYIRV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	101/344 (29%)
		Calpain_III	346..483	CDD:238132	37/144 (26%)
		FRQ1	<567..648	CDD:227455
capn8.5	XP_002939795.1	Peptidase_C2	33..319	CDD:279042	98/332 (30%)
capn8.5	XP_002939795.1	Calpain_III	333..465	CDD:294111	36/142 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010