DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpC and capn3b

DIOPT Version :9

Sequence 1:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001230250.1	Gene:	capn3b / 100034405	ZFINID:	ZDB-GENE-041001-149	Length:	723	Species:	Danio rerio

Alignment Length:	723	Identity:	212/723 - (29%)
Similarity:	360/723 - (49%)	Gaps:	106/723 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAP 65
            :..||.|       |.||:|||.|||..||:||.:..|...:|||.|::..:            |
Zfish    55 LRDKYVR-------KKVLFEDPLFPAQDSSLFYSEKFPLKLEWKRPMEICKN------------P 100

  Fly    66 VF-LNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWV 128
            .| |..:...|:..|.:||.||::.:..|:....:..||||.||:....: |:|.|:.|..||||
Zfish   101 QFILGGANRTDICQGDLGDCWLLAAIACLTLNDVILKRVVPHDQSFTENYAGIFHFQFWRYGEWV 165

  Fly   129 EVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV---- 189
            :|::||||||...:|.|.:...:|.||:||:|||.|||||||||||.|...:.:.|..|||
Zfish   166 DVVIDDRLPTYKNKLVFTRSGQNNEFWSALMEKAYAKLHGSYEALKGGNSLEAMEDFTGGVTEFY 230

  Fly   190 -VRQMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVK 253
             :.:.|....||..:.||.    ..::.|..|.....|::.   :..:|::....|.::.:::.|
Zfish   231 EITEAPKELYNIMRKALKR----GSLMGCAIDTLVPTAQRT---KTASGLVRGHAYSVTGVEQGK 288

  Fly   254 TLMGDS--VQLVCLKDTFS-SKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLG-PGEFWLS 314
            ...|..  ::||.::|.:. :.|...|::   ||..::||     :.::.||  |.| .||||:.
Zfish   289 RKDGKDLMIRLVRVRDPWGVAPPPACKSN---DWVELAKT-----EQDKQRL--QPGEQGEFWMC 343

  Fly   315 FCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQ- 377
            |.:|.:.|:.:|:..|..:|..|::|.|     |.:.:|:|:|.:|.:||||||. :::..|||
Zfish   344 FEEFQKNFTKLEICNLTPDTLEDDQMFK-----WNVTVHEGRWVKGCSAGGCRNFPDTYWTNPQF 403

  Fly   378 -LLISVQDEQD----LVIALNQ-------------HTAVEPKVIGFTMYTWDGEYM--LSECLQK 422
             |::...|.::    :|:||.|             |.      |||.:|....|..  ..:.|.|
Zfish   404 RLVLLEADAKEKTCTVVVALMQKGRRVERCSGATLHN------IGFAIYEVPKEMKGNQQQQLSK 462

  Fly   423 DFFKNHVSYLNS-DYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRIL----GTGSFRLSC 482
            |||..:.|...| .|.|.|.|:....|:.|.||:||:|::|.:|:.|.:|:.    .|.....:.
Zfish   463 DFFLYNASTARSKSYVNIREVTERFCLKPGEYVIIPSTFDPHKESEFLLRVFSENRSTSKVIDAE 527

  Fly   483 LETQTMIL------LDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEA 541
            :|.:.|.:      :.||.. :.|:.|:          |:..::.|:|.::..||..||..:|..
Zfish   528 IEAEPMQVDNVKKKIKPFEE-EETEEEK----------QFRAIFQQIAGDDMEINANELRTVLNR 581

  Fly   542 CLPND---YIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILR 603
            .:...   ..:| .:::.||.:|||.|..|:|.:..|:||.....:|.|:.||..:..:|:..:.
Zfish   582 VVAKHKELKTEG-FSLESCRSMIALLDTDGTGHLNLQEFKHLWNKIKQWKLVFTRFDTDKSSTIS 645

  Fly   604 AERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIE 668
            :..:|:||.:.||||:..:.:.:..||..:...|....::|.::.|...|..|...:.....:|:
Zfish   646 SFEMRNALTEAGFQLNNQLYDIICMRYANEHMELDFDSYISCLVRLEGMFRAFRAFDKDGDGLIK 710

  Fly   669 VHLHDWIK 676
            :::.:|::
Zfish   711 LNVFEWLQ 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	109/332 (33%)
		Calpain_III	346..483	CDD:238132	49/163 (30%)
		FRQ1	<567..648	CDD:227455	21/80 (26%)
capn3b	NP_001230250.1	Peptidase_C2	66..358	CDD:279042	105/320 (33%)
		Calpain_III	372..519	CDD:279416	48/152 (32%)
		EFh	555..623	CDD:298682	20/68 (29%)
		EFh	599..654	CDD:238008	18/54 (33%)
		EFh	630..719	CDD:298682	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920