DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1 and CPR7

DIOPT Version :9

Sequence 1:	NP_523366.2	Gene:	Cyp1 / 32595	FlyBaseID:	FBgn0004432	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_012566.1	Gene:	CPR7 / 853489	SGDID:	S000003793	Length:	393	Species:	Saccharomyces cerevisiae

Alignment Length:	172	Identity:	71/172 - (41%)
Similarity:	94/172 - (54%)	Gaps:	31/172 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTG--------EKGFGYKGSIFHRVIPNF 123
            |.|:.|::.|.:|:||||.:|..:..|||.|||..||.|        ::...|||:.||||:.||
Yeast     5 PLVYLDISIDKKPIGRIVCKLFREKAPKTTENFYKLCAGDVKSPLKDQQYLSYKGNGFHRVVKNF 69

  Fly   124 MCQGGDF---------TNHNGTGGKSIYGN----KFPDE-----NFELKHTGSGI----LSMANA 166
            |.|.||.         ::..|.||.|||.:    |..||     |||.::.|..:    |.|||.
Yeast    70 MIQAGDIVFGTQKDSSSSSVGKGGCSIYADKEEVKTDDESFCYGNFEDENLGEFVEPFTLGMANL 134

  Fly   167 GA-NTNGSQFFICTVKTAWLDNKHVVFGEVVEGLDVVKKIES 207
            |: |||.|||||.|.....|:.||.:||:||.|..||:.||:
Yeast   135 GSPNTNNSQFFITTYAAPHLNGKHSIFGQVVHGKSVVRTIEN 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	71/172 (41%)
CPR7	NP_012566.1	cyclophilin	5..195	CDD:412213	71/172 (41%)
		TPR	<233..383	CDD:223533
		TPR repeat	274..321	CDD:276809
		TPR_16	296..353	CDD:404335
		TPR_1	330..363	CDD:395414
		TPR repeat	330..353	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910