DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp1 and PPID

DIOPT Version :9

Sequence 1:NP_523366.2 Gene:Cyp1 / 32595 FlyBaseID:FBgn0004432 Length:227 Species:Drosophila melanogaster
Sequence 2:NP_005029.1 Gene:PPID / 5481 HGNCID:9257 Length:370 Species:Homo sapiens


Alignment Length:178 Identity:103/178 - (57%)
Similarity:125/178 - (70%) Gaps:9/178 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 SKASKMSTLPRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTGEKGFG--------YKGS 114
            :|.|..|. ||||||:....|.:||||:||.:|:|||||||||||||||||.|        :||.
Human     8 AKPSNPSN-PRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGC 71

  Fly   115 IFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENFELKHTGSGILSMANAGANTNGSQFFICT 179
            .|||:|..||.|||||:|.|||||:||||.||.||||..||...|:|||||||.|||||||||.|
Human    72 PFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITT 136

  Fly   180 VKTAWLDNKHVVFGEVVEGLDVVKKIESYGSQSGKTSKKIIVANSGSL 227
            |.|..||.||||||:|::|:.|.:.:|:...:..|.:|..::|..|.|
Human   137 VPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGEL 184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp1NP_523366.2 cyclophilin_ABH_like 67..225 CDD:238907 98/165 (59%)
PPIDNP_005029.1 cyclophilin_ABH_like 16..182 CDD:238907 98/165 (59%)
Chaperone activity. /evidence=ECO:0000250 185..215 103/178 (58%)
PLN03088 192..>362 CDD:330826
Interaction with HSP90AB1. /evidence=ECO:0000250 214..370
TPR repeat 224..267 CDD:276809
TPR repeat 272..302 CDD:276809
TPR repeat 307..333 CDD:276809
TPR repeat 341..364 CDD:276809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0652
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1403619at2759
OrthoFinder 1 1.000 - - FOG0000032
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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