Protein Alignment Cyp1 and PPID

DIOPT Version :10

• Sequence 1: NP_523366.2
• Gene: Cyp1 / 32595
• FlyBaseID: FBgn0004432
• Length: 227
• Species: Drosophila melanogaster
• Sequence 2: NP_005029.1
• Gene: PPID / 5481
• HGNCID: 9257
• Length: 370
• Species: Homo sapiens
• Alignment Length: 178
• Identity: 103/178 - (57%)
• Similarity: 125/178 - (70%)
• Gaps: 9/178 - (5%)

  Fly    58 SKASKMSTLPRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTGEKGFG--------YKGS 114
            :|.|..|. ||||||:....|.:||||:||.:|:|||||||||||||||||.|        :||.
Human     8 AKPSNPSN-PRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGC 71

  Fly   115 IFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENFELKHTGSGILSMANAGANTNGSQFFICT 179
            .|||:|..||.|||||:|.|||||:||||.||.||||..||...|:|||||||.|||||||||.|
Human    72 PFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITT 136

  Fly   180 VKTAWLDNKHVVFGEVVEGLDVVKKIESYGSQSGKTSKKIIVANSGSL 227
            |.|..||.||||||:|::|:.|.:.:|:...:..|.:|..::|..|.|
Human   137 VPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGEL 184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	98/165 (59%)
PPID	NP_005029.1	cyclophilin_ABH_like	16..182	CDD:238907	98/165 (59%)
		Chaperone activity. /evidence=ECO:0000250	185..215		103/178 (58%)
		TPR	213..>367	CDD:440225
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370
		TPR repeat	224..267	CDD:276809
		TPR repeat	272..302	CDD:276809
		TPR repeat	307..333	CDD:276809
		TPR repeat	341..364	CDD:276809