DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1 and PPIB

DIOPT Version :9

Sequence 1:	NP_523366.2	Gene:	Cyp1 / 32595	FlyBaseID:	FBgn0004432	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_000933.1	Gene:	PPIB / 5479	HGNCID:	9255	Length:	216	Species:	Homo sapiens

Alignment Length:	203	Identity:	109/203 - (53%)
Similarity:	141/203 - (69%)	Gaps:	10/203 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NKSITLASSACSVNRGQLQF----GIQIVREYSKASKMSTLPRVFFDMTADNEPLGRIVMELRSD 90
            |..:.||::..:   |.:.|    |.....|..|..|::.  :|:||:...:|.:||::..|...
Human     8 NMKVLLAAALIA---GSVFFLLLPGPSAADEKKKGPKVTV--KVYFDLRIGDEDVGRVIFGLFGK 67

  Fly    91 VVPKTAENFRALCTGEKGFGYKGSIFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENFELKH 155
            .||||.:||.||.|||||||||.|.|||||.:||.||||||..:|||||||||.:||||||:|||
Human    68 TVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKH 132

  Fly   156 TGSGILSMANAGANTNGSQFFICTVKTAWLDNKHVVFGEVVEGLDVVKKIESYGSQS-GKTSKKI 219
            .|.|.:||||||.:||||||||.||||||||.||||||:|:||::||:|:||..:.| .|..|.:
Human   133 YGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDV 197

  Fly   220 IVANSGSL 227
            |:|:.|.:
Human   198 IIADCGKI 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	99/158 (63%)
PPIB	NP_000933.1	cyclophilin_ABH_like	45..203	CDD:238907	99/157 (63%)
PPIB	NP_000933.1	Prevents secretion from ER	213..216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53630
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830