DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1 and Ppid

DIOPT Version :9

Sequence 1:	NP_523366.2	Gene:	Cyp1 / 32595	FlyBaseID:	FBgn0004432	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_001004279.1	Gene:	Ppid / 361967	RGDID:	1303174	Length:	370	Species:	Rattus norvegicus

Alignment Length:	180	Identity:	105/180 - (58%)
Similarity:	124/180 - (68%)	Gaps:	10/180 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SKASKMSTL--PRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTGEKGFG--------YK 112
            |.|.|.|..  ||||||:....|.:||||:||.:|:|||||||||||||||||.|        :|
  Rat     5 SPAGKPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGPTTGKPLHFK 69

  Fly   113 GSIFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENFELKHTGSGILSMANAGANTNGSQFFI 177
            |..|||:|..||.|||||:|.|||||:||||.||.||||..||...|:|||||||.|||||||||
  Rat    70 GCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGPNTNGSQFFI 134

  Fly   178 CTVKTAWLDNKHVVFGEVVEGLDVVKKIESYGSQSGKTSKKIIVANSGSL 227
            .||.|..||.||||||:|::||.|.:.:|:......|.:|..::|..|.|
  Rat   135 TTVPTPHLDGKHVVFGQVIKGLGVARMLENVEVNGEKPAKLCVIAECGEL 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	99/165 (60%)
Ppid	NP_001004279.1	cyclophilin_ABH_like	16..182	CDD:238907	99/165 (60%)
		Chaperone activity. /evidence=ECO:0000250	185..215		105/180 (58%)
		3a0801s09	192..>330	CDD:273380
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370
		TPR repeat	223..251	CDD:276809
		TPR repeat	272..302	CDD:276809
		TPR repeat	307..335	CDD:276809
		TPR repeat	341..364	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820