DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1 and wis2

DIOPT Version :9

Sequence 1:	NP_523366.2	Gene:	Cyp1 / 32595	FlyBaseID:	FBgn0004432	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_594787.1	Gene:	wis2 / 2542541	PomBaseID:	SPAC1B3.03c	Length:	356	Species:	Schizosaccharomyces pombe

Alignment Length:	168	Identity:	89/168 - (52%)
Similarity:	111/168 - (66%)	Gaps:	6/168 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 MSTLPRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTGEKGFG----YKGSIFHRVIPNF 123
            |||.  .:|.::.|.:....|..||..:|||||.:||.:||.|.:..|    ||||.|||||.||
pombe     1 MSTY--AYFKISIDGKIQPTIYFELFDNVVPKTVKNFASLCNGFEKDGRCLTYKGSRFHRVIKNF 63

  Fly   124 MCQGGDFTNHNGTGGKSIYGNKFPDENFELKHTGSGILSMANAGANTNGSQFFICTVKTAWLDNK 188
            |.||||||..|||||:||||.||.||||||||....:|||||||.|||||||||.||.|..||.|
pombe    64 MLQGGDFTRGNGTGGESIYGEKFEDENFELKHDKPFLLSMANAGPNTNGSQFFITTVPTPHLDGK 128

  Fly   189 HVVFGEVVEGLDVVKKIESYGSQSGKTSKKIIVANSGS 226
            |||||:|::|...|:.||:..:::......:::...|:
pombe   129 HVVFGKVIQGKSTVRTIENLETKNDDPVVPVVIEECGT 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	85/161 (53%)
wis2	NP_594787.1	cyclophilin	6..165	CDD:294131	85/158 (54%)
		TPR_11	204..287	CDD:290150
		TPR repeat	204..253	CDD:276809
		TPR repeat	258..288	CDD:276809
		TPR_11	261..323	CDD:290150
		TPR repeat	293..323	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810