DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1 and PPIL2

DIOPT Version :9

Sequence 1:	NP_523366.2	Gene:	Cyp1 / 32595	FlyBaseID:	FBgn0004432	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	XP_011528343.1	Gene:	PPIL2 / 23759	HGNCID:	9261	Length:	616	Species:	Homo sapiens

Alignment Length:	138	Identity:	71/138 - (51%)
Similarity:	86/138 - (62%)	Gaps:	6/138 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GRIVMELRSDVVPKTAENFRALCTGEKGFGYKGSIFHRVIPNFMCQGGDFTNHNGTGGKSIYGNK 145
            |.:.:||..|:.|||.|||..||   |...|.|:||||.|.||:.||||.|. .||||:|.:|..
Human   289 GDLNLELHCDLTPKTCENFIRLC---KKHYYDGTIFHRSIRNFVIQGGDPTG-TGTGGESYWGKP 349

  Fly   146 FPDE-NFELKHTGSGILSMANAGANTNGSQFFICTVKTAWLDNKHVVFGEVVEGLDVVKKIESYG 209
            |.|| ...|.|||.|||||||:|.|:|.|||||.....|:||.||.:||.||.|.||:..:|:..
Human   350 FKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVE 414

  Fly   210 SQSGKTSK 217
            |.. ||.:
Human   415 SDP-KTDR 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	71/138 (51%)
PPIL2	XP_011528343.1	RING-Ubox_PPIL2	38..110	CDD:319577
		RING_Ubox	100..159	CDD:388418
		U-box domain, a modified RING finger	103..146	CDD:319361
		cyclophilin_RING	281..440	CDD:238904	71/138 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810