Protein Alignment Cyp1 and PPWD1

DIOPT Version :10

• Sequence 1: NP_523366.2
• Gene: Cyp1 / 32595
• FlyBaseID: FBgn0004432
• Length: 227
• Species: Drosophila melanogaster
• Sequence 2: NP_056157.1
• Gene: PPWD1 / 23398
• HGNCID: 28954
• Length: 646
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 82/227 - (36%)
• Similarity: 116/227 - (51%)
• Gaps: 27/227 - (11%)

  Fly    13 RHRSAAAFQI--AESAILAN--KSITLASSACSVNRGQL-----------------QFGIQIVRE 56
            :||:|...::  :|:.:|.|  ...|:..::...||..:                 .|..:..:|
Human   412 KHRAATTIEMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKE 476

  Fly    57 YSKASKMSTLPRVFFDMTADNEPLGRIVMELRSDVVPKTAENFRALCTGEKGFGYKGSIFHRVIP 121
            ...|:..:..|:...|....:..:|.|..:|.....|||.|||   |...:...|.|..|||:|.
Human   477 EVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENF---CVHSRNGYYNGHTFHRIIK 538

  Fly   122 NFMCQGGDFTNHNGTGGKSIYGNKFPDE-NFELKHTGSGILSMANAGANTNGSQFFICTVKTAWL 185
            .||.|.||.|. .|.||:||:|.:|.|| :..|:|.....|||||||:|||||||||..|.|.||
Human   539 GFMIQTGDPTG-TGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWL 602

  Fly   186 DNKHVVFGEVVEGLDVVKKIESYGSQSGKTSK 217
            ||||.|||.|.:|::||::|.:. ..:.||.|
Human   603 DNKHTVFGRVTKGMEVVQRISNV-KVNPKTDK 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	70/152 (46%)
PPWD1	NP_056157.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		WD 1	80..118
		WD40	<89..319	CDD:441893
		WD 2	124..162
		WD40 repeat	136..177	CDD:293791
		WD 3	168..208
		WD40 repeat	191..219	CDD:293791
		WD 4	213..252
		WD40 repeat	226..277	CDD:293791
		WD 5	271..309
		WD40 repeat	283..326	CDD:293791
		WD 6	345..386
		WD 7	401..453		9/40 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..490		4/34 (12%)
		cyclophilin_WD40	495..643	CDD:238908	68/144 (47%)