DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp1 and PPIF

DIOPT Version :9

Sequence 1:	NP_523366.2	Gene:	Cyp1 / 32595	FlyBaseID:	FBgn0004432	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_005720.1	Gene:	PPIF / 10105	HGNCID:	9259	Length:	207	Species:	Homo sapiens

Alignment Length:	200	Identity:	133/200 - (66%)
Similarity:	157/200 - (78%)	Gaps:	14/200 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KSITL---ASSACSVNRGQLQFGIQIVREYSKASKMSTLPRVFFDMTADNEPLGRIVMELRSDVV 92
            :|:.|   |:.|||...|.           ..:|..|..|.|:.|:.|:.:||||:|:||::|||
Human    18 RSVPLRLPAARACSKGSGD-----------PSSSSSSGNPLVYLDVDANGKPLGRVVLELKADVV 71

  Fly    93 PKTAENFRALCTGEKGFGYKGSIFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENFELKHTG 157
            ||||||||||||||||||||||.||||||:||||.||||||||||||||||::||||||.|||.|
Human    72 PKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVG 136

  Fly   158 SGILSMANAGANTNGSQFFICTVKTAWLDNKHVVFGEVVEGLDVVKKIESYGSQSGKTSKKIIVA 222
            .|:|||||||.|||||||||||:||.|||.||||||.|.||:||||||||:||:||:|||||::.
Human   137 PGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGRTSKKIVIT 201

  Fly   223 NSGSL 227
            :.|.|
Human   202 DCGQL 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp1	NP_523366.2	cyclophilin_ABH_like	67..225	CDD:238907	122/157 (78%)
PPIF	NP_005720.1	cyclophilin_ABH_like	46..204	CDD:238907	122/157 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1907
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38696
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2973
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53630
OrthoDB	1	1.010	-	-		D1403619at2759
OrthoFinder	1	1.000	-	-		FOG0000032
OrthoInspector	1	1.000	-	-		otm41055
orthoMCL	1	0.900	-	-		OOG6_100528
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R284
SonicParanoid	1	1.000	-	-		X209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770