Protein Alignment SWIP and washc4

DIOPT Version :9

• Sequence 1: NP_573116.2
• Gene: SWIP / 32594
• FlyBaseID: FBgn0030739
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_694117.3
• Gene: washc4 / 565752
• ZFINID: ZDB-GENE-100427-4
• Length: 1173
• Species: Danio rerio
• Alignment Length: 1203
• Identity: 340/1203 - (28%)
• Similarity: 595/1203 - (49%)
• Gaps: 202/1203 - (16%)

  Fly     7 LRDYGSFISEHDGKLKLLRDKVPNR--DVSESAQCVYMSPVVEVNFMGNDSMAPDRSFEESEL-- 67
            :::|..|:.|:..:|:.:.:.:.:.  ||.:..    :.|:..       .:.|   :|:|.|
Zfish    28 VKNYERFLEEYIAQLQGIEEALDDSIGDVWDFT----LDPITL-------KLLP---YEQSSLLE 78

  Fly    68 -------VANKPLTTLANLCNQCRNLSRKAK-RFQLAFLFSDFRLDDTLPPHTHTSEGSAGLEG- 123
                   |.||.:|..|.||.:.:.|..:|: :|....|:....:.||           :.:||
Zfish    79 LIKTDNKVLNKVITVYAALCCEVKKLKHEAETKFYNGLLYYGEGVSDT-----------SVVEGE 132

  Fly   124 SLVRMSSSMDFFCQVYFLLNRMIVILQNLWRQIAA------SVSVPMDINEVHIFAVFDAMSELL 182
            |.::|...:.|..::...::|...::.|:..|:||      ..:..::...||...|::.:.|||
Zfish   133 SQIQMGRFVSFLQELSCFVSRCFEVVVNMVHQLAALYNSSKGATKIIESTGVHFQTVYEHLGELL 197

  Fly   183 EHIVVFNE-LANQSKISTMWALYKKWLMNLSNSQSANLELNGLSTSLMDIENLITKDFFRI---L 243
            ..::..:| :.|.:.:...|.:||:.|.::.:: .|...:.  ...|...|.||    |::   |
Zfish   198 VVLITLDEIMENHATLKEHWKMYKRLLKSVHHN-PAKFAIP--EEKLKPFEKLI----FKLEGQL 255

  Fly   244 LDNLME---LKKQF---GLN-SVSPITQHSN--AYIRRQLLDVDANPSNELKNYEDPKHIIRLTT 299
            ||:::.   ::::|   |.| |||..:..:.  ||..|.:.   ||..::|   .:|..|.:...
Zfish   256 LDSMIFQACVEQRFDNPGENVSVSKNSAFAEEFAYNIRTIF---ANVESKL---GEPSEIDQRDK 314

  Fly   300 F-----VVVVH-ELGIQMEGKLVKNVIDLVARHKQVPLNRSVFWSPSGFLSLHAKTLMKSSARSQ 358
            :     :.|:| .:...::.|:.|:::|:..:...|.|..::.|.|..||      :.|..|.::
Zfish   315 YTGVCGLFVLHFHIFRAVDKKIYKSLLDVCKKVPAVTLAANIIWFPDTFL------INKVPAAAK 373

  Fly   359 DGQGPKVHSTVLEKFRLSDQRTCRQLGVQ----------------LSLWSIQMQRV--------- 398
                      :::|..|...|:.|.:.:|                ::.|.::|:.:
Zfish   374 ----------LMDKKSLQSIRSSRDVFLQQKAQTLMKDMQSYYIFVTSWMMKMESILSKEPKPDK 428

  Fly   399 FDVGVFGHLKTFLQLILNGHSYADQVNLLAVALINRHVALMTPMTRNDWIVVSRLLQYLKVIQKT 463
            ....:......|:|.||    ||..::.:....:|.::::..|||:.....:.||::.||.::.|
Zfish   429 LSEDLSNRCNIFVQGIL----YAYSISTIIKTTMNMYMSMQRPMTKTSVKALCRLVELLKAVEHT 489

  Fly   464 FESNQINFVRFISSLI-QWQKQKVIHLLHTTKKKIVVLKLLQRKINFLATIKLAEKSIMGFPSKQ 527
            |....:.....:|.:. |.|.|.::.:....|:.|...|..:::::.|:.:.|||.::.|..:|:
Zfish   490 FHRRSLVVADSVSHITQQLQSQALVSISMAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKE 554

  Fly   528 RLTFVNLALG------EFLDNRLLPADNQKLIKSILHRVNSISDIMRNIGGQLNTSESSSLVYNH 586
            |...::|||.      .|.|..|||      ::.:|.:::.||::...:..|.:.|      :.:
Zfish   555 RRLIMSLALSVGTQMKTFKDEELLP------LQLVLKKLDLISELRERVKVQCDCS------FLY 607

  Fly   587 W-------FLDTSVLKEYTELQRNPY---SLQNLVSVSHH------LDKIMAMFRGSRCPKQSAN 635
            |       :|| .|.:...:..|..|   :|::.|....|      .|:::..:          :
Zfish   608 WHRTVFPIYLD-DVYENAVDAARIHYMFSALRDCVPTMLHAKHMESCDQLLECY----------D 661

  Fly   636 DLIIEFLSNHL--------EFFLRVEALSHLFQSQDQPFQQSALDYRLCINAVAVENDGDYNIIK 692
            ..|:|.|:.||        |..||:...:||......||:....|.....:...:.....:..||
Zfish   662 TEIMEILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGMKDLAHFFSLKPIRFFNRFIDIK 726

  Fly   693 DHLENYFTATFYNLTTIAPHDWKSYEKMRHLANKVLQLQPIDDHLPNQIIDQGIDVLQIMRNIHT 757
            .::.:|...|||||||:|.|||.:|.:||:||.:...|...:.|||:|.::||:|||:||||||.
Zfish   727 AYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHV 791

  Fly   758 FASSYAYNMNLQVFVETNSRSKHLDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTF 822
            |.|.|.||:|.|:|:|..|.:|||:.|..||:|||::||||||:||||||.|||||:|||.||.|
Zfish   792 FVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLRKKFYIFSQF 856

  Fly   823 LHDEQIKSRLLKELRFHTEHKHSKSYQSYPYERADSFLKKIRRLGCSSNGETYMDLFRKVITQVG 887
            ::||.|||||:|::||..|.| .::.|.||:|||:.|.:.||:||.:.:|::|:|.||::|:|:|
Zfish   857 MYDEHIKSRLIKDIRFFRETK-DQTDQKYPFERAEKFNRGIRKLGLTPDGQSYLDQFRQLISQIG 920

  Fly   888 NAVGYVRLLQAGSKNANFRNRSYKTRFDS------NFSCGGSKVHEATEGSIREYEKSLGHMKEC 946
            ||:||||::::|..:.    .|...||..      ||.   ..|.|  ||...|.:|:...:...
Zfish   921 NAMGYVRMIRSGGLHC----CSSAIRFVPDLEDIVNFE---ELVKE--EGLSEETQKASSQLDCV 976

  Fly   947 YSD-------STNYFKLLLQGFQPFLCNPHNHHLRTFYLITPALIMNYIDYRVKQKLKIYKKDQT 1004
            .||       .|.|||:|:..|.|...:..|.|||.||:|.|.|.:|::::.:..|.|:.||::.
Zfish   977 LSDLTSNSAEGTEYFKMLVGVFAPEFRSIKNMHLRNFYMIVPPLTVNFVEHSISCKEKLNKKNKV 1041

  Fly  1005 KISLFEDGFAIGLVYILNMLNQQTEFHELGWSQTITQHLNAERSKVRDILAGQQRTAPEQLDEKL 1069
            ..:..:||||:|:.|||.:|:|..||..|.|.|.:.:....|.:.|    ..:|.......||||
Zfish  1042 GAAFTDDGFAMGVAYILKLLDQYQEFDSLHWFQAVREKYVKEMNAV----VKEQNVQSTSQDEKL 1102

  Fly  1070 HQTVAITERHVNAYEHEYNLLYATLSSSEIFFQ 1102
            .||:.:|::.::.|..|:.|||.:|||:.|||:
Zfish  1103 MQTMNLTQKRLDVYLQEFELLYFSLSSARIFFR 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SWIP	NP_573116.2	WASH-7_N	11..573	CDD:291415	129/631 (20%)
		WASH-7_mid	592..910	CDD:291414	135/334 (40%)
		WASH-7_C	929..1102	CDD:291416	62/179 (35%)
washc4	XP_694117.3	WASH-7_N	34..600	CDD:291415	129/629 (21%)
		WASH-7_mid	612..945	CDD:291414	140/348 (40%)
		WASH-7_C	966..1135	CDD:291416	59/172 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583247
Domainoid	1	1.000	261	1.000	Domainoid score	I1919
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123926
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1693
OMA	1	1.010	-	-		QHG54471
OrthoDB	1	1.010	-	-		D186054at2759
OrthoFinder	1	1.000	-	-		FOG0006906
OrthoInspector	1	1.000	-	-		oto38959
orthoMCL	1	0.900	-	-		OOG6_104381
Panther	1	1.100	-	-	LDO	PTHR31409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4324
SonicParanoid	1	1.000	-	-		X5010
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940