Protein Alignment SWIP and Washc4

DIOPT Version :10

• Sequence 1: NP_573116.2
• Gene: SWIP / 32594
• FlyBaseID: FBgn0030739
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_036011700.1
• Gene: Washc4 / 319277
• MGIID: 2441787
• Length: 1218
• Species: Mus musculus
• Alignment Length: 1189
• Identity: 313/1189 - (26%)
• Similarity: 558/1189 - (46%)
• Gaps: 211/1189 - (17%)

  Fly     3 AEDILRDYGSFISEHDGKLKLLRDKVPNRDVSESAQCVYMSPVVEVNFMGNDSMAPDRSFEESEL 67
            ||..|::||.|:.|:..:|:.:.|.:.  |:........:.|:..       .:.|   :|:|.|
Mouse   114 AEVQLKNYGRFLEEYTSQLRRIEDALD--DLIGDVWDFNLDPIAL-------KLLP---YEQSSL 166

  Fly    68 ---------VANKPLTTLANLCNQCRNLSRKAK-RFQLAFLFSDFRLDDTLPPHTHTSEGSAGLE 122
                     |.||.:|..|.||.:.:.|..:|: :|....||           :...:..|:.:|
Mouse   167 LELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLF-----------YGEGATDSSMVE 220

  Fly   123 GSL-VRMSSSMDFFCQVYFLLNRMIVILQNLWRQIAA---SVSVPMDINE---VHIFAVFDAMSE 180
            |.. ::|...:.|..::...:.|...::.|:..|:||   |..:...|.|   ||...:::.:.|
Mouse   221 GDCQIQMGRFVSFLQELSCFVTRCYEVVMNVIHQLAALYISNKIGPKIIETTGVHFQTMYEHLGE 285

  Fly   181 LLEHIVVFNELA-NQSKISTMWALYKKWLMNLSNSQS----ANLELNGLSTSLMDIENLITKDFF 240
            ||..::..:|:. |...:...|.:||:.|.::.::.|    ...:|......|:.:|..
Mouse   286 LLTVLLTLDEIVDNHVTLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQ------ 344

  Fly   241 RILLDNLME---LKKQF-GLNSVSPITQHSN--AYIRRQLLDVDANPSNELKNYEDPKHIIRLTT 299
              |||.::.   :::|| .||....::::|.  ......:..:.||...:|   .:|..|.:...
Mouse   345 --LLDGMIFQACIEQQFDSLNGGISVSKNSTFAEEFAHSIRSIFANVEAKL---GEPSEIDQRDK 404

  Fly   300 FV-----VVVH-ELGIQMEGKLVKNVIDLVARHKQVPLNRSVFWSPSGFLSLH-----AKTLMKS 353
            :|     .|:| ::...::.|..|:::|:..:...:.|..::.|.|..|| :|     ||.|.:.
Mouse   405 YVGICGLFVLHFQIFRTVDKKFYKSLLDICKKVPAITLTANIIWFPDNFL-IHKMPAAAKLLDRK 468

  Fly   354 SARSQDGQGPKVH-STVLEKFRLSDQRTCRQLGVQLSLWSIQMQRVFD----VGVFGH-LKTFLQ 412
            |.     |..|:| .|.|::...|..:..:...|.:|.|.::|:.:..    :..|.. |.....
Mouse   469 SL-----QAIKIHRDTFLQQKAQSLNKDVQSYYVFVSSWMMKMESMLSKEQRMDTFAEDLTNRCN 528

  Fly   413 LILNGHSYADQVNLLAVALINRHVALMTPMTRNDWIVVSRLLQYLKVIQKTFESNQINFVRFISS 477
            :.:.|..||..::.:....:|.::::..|||:.....:.||::.||.|:..|....:.....:|.
Mouse   529 VFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLIELLKAIEHMFYRRSMVVADSVSH 593

  Fly   478 LIQWQKQKVIHLLHTTKKKIVV-LKLLQRKINFLATIKLAEKSIMGFPSKQRLTFVNLALG---- 537
            :.|..:.:.:..:...||:::. .|..:::::.|:.:.|||.::.|..:|||...|:|||.
Mouse   594 ITQHLQHQALSSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQ 658

  Fly   538 --EFLDNRLLPADNQKLIKSILHRVNSISDIMRNIGGQLNTSESSSLVYNHW-------FLDTSV 593
              .|.|..|.|      ::.::.:::.||::...:..|.:      ..:.:|       :|| .|
Mouse   659 MKTFKDEELFP------LQVVMKKLDLISELRERVQAQCD------CCFLYWHRAVFPIYLD-DV 710

  Fly   594 LKEYTELQRNPY---SLQNLVSV---SHHLD-----------KIMAMFRGSRCPKQSANDLIIEF 641
            .:...:..|..|   :|::.|..   |.||:           :||.:.          |:.:::.
Mouse   711 YENAVDAARLHYMFSALRDCVPAMMHSRHLESHELLLDCYDKEIMDIL----------NEHLLDK 765

  Fly   642 LSNHLEFFLRVEALSHLFQSQDQPFQQSALDYRLCINAVAVENDGDYNIIKDHLENYFTATFYNL 706
            |...:|..||:...:||......||:....|..|..:...:.....:..|:.::.:|...|||||
Mouse   766 LCKEIEKDLRLSVHTHLKLDDRNPFKVGRKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNL 830

  Fly   707 TTIAPHDWKSYEKMRHLANKVLQLQPIDDHLPNQIIDQGIDVLQIMRNIHTFASSYAYNMNLQVF 771
            ||:|.|||.:|.:||:||.:...|...:.|||:|.::||:|||:||||||.|.|.|.||:|.|:|
Mouse   831 TTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIF 895

  Fly   772 VETNSRSKHLDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDEQIKSRLLKEL 836
            :|..|.:|||:.|..||:|||::||||||:|||
Mouse   896 IERTSNNKHLNTINIRHIANSIRTHGTGIMNTT-------------------------------- 928

  Fly   837 RFHTEHKHSKSYQSYPYERADSFLKKIRRLGCSSNGETYMDLFRKVITQVGNAVGYVRLLQAGSK 901
                          ||::||:.|.:.||:||.:..|::|:|.||::|:|:|||:||:|::::|..
Mouse   929 --------------YPFDRAEKFNRGIRKLGITPEGQSYLDQFRQLISQIGNAMGYIRMIRSGGL 979

  Fly   902 NANFRNRSYKTRFDSNFS---CGGSKVHEATEGSIREYEKSLGHMKECYSD-------STNYFKL 956
            :.:    |...||..:..   .....|.|  ||...|..::..|:....||       .|.|||:
Mouse   980 HCS----SNAIRFVPDLEDIVSFEELVKE--EGLAEETLRAARHLDSVLSDHTRNSAEGTEYFKM 1038

  Fly   957 LLQGFQPFLCNPHNHHLRTFYLITPALIMNYIDYRVKQKLKIYKKDQTKISLFEDGFAIGLVYIL 1021
            |:..|.|....|.|.|||.||:|.|.|.:|::::.:..|.|:.||::...:..:||||:|:.|.|
Mouse  1039 LVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKLGAAFTDDGFAMGVAYTL 1103

  Fly  1022 NMLNQQTEFHELGWSQTITQHLNAERSK-VRDI--LAGQQRTAPEQLDEKLHQTVAITERHVNAY 1083
            .:|:|..||..|.|.|::       |.| :::|  :|.||.......||||.||:.:|::.:..|
Mouse  1104 KLLDQYQEFDSLHWFQSV-------REKYIKEIRAVAKQQNVQSTSQDEKLLQTMNLTQKRLEVY 1161

  Fly  1084 EHEYNLLYATLSSSEIFFQ 1102
            ..|:.|||.:|||:.|||:
Mouse  1162 LQEFELLYFSLSSARIFFR 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SWIP	NP_573116.2	WASH-4_N	11..573	CDD:434178	128/613 (21%)
		WASH-7_mid	582..910	CDD:434177	109/351 (31%)
		WASH-7_C	929..1102	CDD:464293	65/182 (36%)
Washc4	XP_036011700.1	WASH-4_N	122..690	CDD:434178	128/613 (21%)
		WASH-7_mid	695..994	CDD:434177	112/359 (31%)
		WASH-7_C	1011..1180	CDD:464293	62/175 (35%)