Protein Alignment SWIP and WASHC4

DIOPT Version :10

• Sequence 1: NP_573116.2
• Gene: SWIP / 32594
• FlyBaseID: FBgn0030739
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_001280569.1
• Gene: WASHC4 / 23325
• HGNCID: 29174
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 1198
• Identity: 345/1198 - (28%)
• Similarity: 594/1198 - (49%)
• Gaps: 183/1198 - (15%)

  Fly     3 AEDILRDYGSFISEHDGKLKLLRDKVPNR--DVSESAQCVYMSPVVEVNFMGNDSMAPDRSFEES 65
            ||..|::||.|:.|:..:|:.:.|.:.:.  ||.:    ..:.|:..       .:.|   :|:|
Human    24 AEVQLKNYGKFLEEYTSQLRRIEDALDDSIGDVWD----FNLDPIAL-------KLLP---YEQS 74

  Fly    66 EL---------VANKPLTTLANLCNQCRNLSRKAK-RFQLAFLFSDFRLDDTLPPHTHTSEGSAG 120
            .|         |.||.:|..|.||.:.:.|..:|: :|....||              ..||:..
Human    75 SLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLF--------------YGEGATD 125

  Fly   121 ---LEGSL-VRMSSSMDFFCQVYFLLNRMIVILQNLWRQIAA---SVSVPMDINE---VHIFAVF 175
               :||.. ::|...:.|..::...:.|...::.|:..|:||   |..:...|.|   ||...::
Human   126 ASMVEGDCQIQMGRFISFLQELSCFVTRCYEVVMNVVHQLAALYISNKIAPKIIETTGVHFQTMY 190

  Fly   176 DAMSELLEHIVVFNELA-NQSKISTMWALYKKWLMNLSNSQS----ANLELNGLSTSLMDIENLI 235
            :.:.|||..::..:|:. |...:...|.:||:.|.::.::.|    ...:|......|:.:|..
Human   191 EHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQ- 254

  Fly   236 TKDFFRILLDNLME---LKKQF-GLNSVSPITQHSN--AYIRRQLLDVDANPSNELKNYEDPKHI 294
                   |||.::.   :::|| .||....::::|.  ......:..:.||...:|   .:|..|
Human   255 -------LLDGMIFQACIEQQFDSLNGGVSVSKNSTFAEEFAHSIRSIFANVEAKL---GEPSEI 309

  Fly   295 IRLTTFV-----VVVH-ELGIQMEGKLVKNVIDLVARHKQVPLNRSVFWSPSGFL----SLHAKT 349
            .:...:|     .|:| ::...::.|..|:::|:..:...:.|..::.|.|..||    ...||.
Human   310 DQRDKYVGICGLFVLHFQIFRTIDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIQKIPAAAKL 374

  Fly   350 LMKSSARSQDGQGPKVH-STVLEKFRLSDQRTCRQLGVQLSLWSIQMQRV---------FDVGVF 404
            |.:.|.     |..|:| .|.|::...|..:..:...|.:|.|.::|:.:         |...:.
Human   375 LDRKSL-----QAIKIHRDTFLQQKAQSLTKDVQSYYVFVSSWMMKMESILSKEQRMDKFAEDLT 434

  Fly   405 GHLKTFLQLILNGHSYADQVNLLAVALINRHVALMTPMTRNDWIVVSRLLQYLKVIQKTFESNQI 469
            .....|:|:   |..||..::.:....:|.::::..|||:.....:.||::.||.|:..|....:
Human   435 NRCNVFIQV---GFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLKAIEHMFYRRSM 496

  Fly   470 NFVRFISSLIQWQKQKVIHLLHTTKKKIVV-LKLLQRKINFLATIKLAEKSIMGFPSKQRLTFVN 533
            .....:|.:.|..:.:.:|.:...||:::. .|..:::::.|:.:.|||.::.|..:|||...|:
Human   497 VVADSVSHITQHLQHQALHSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVS 561

  Fly   534 LALG------EFLDNRLLPADNQKLIKSILHRVNSISDIMRNIGGQLNTSESSSLVYNHW----- 587
            |||.      .|.|..|.|      ::.::.:::.||::...:..|.:      ..:.:|
Human   562 LALSVGTQMKTFKDEELFP------LQVVMKKLDLISELRERVQTQCD------CCFLYWHRAVF 614

  Fly   588 --FLDTSVLKEYTELQRNPY---SLQNLVSVSHH----------LD----KIMAMFRGSRCPKQS 633
              :|| .|.:...:..|..|   :|::.|....|          ||    :||.:.
Human   615 PIYLD-DVYENAVDAARLHYMFSALRDCVPAMMHARHLESYEILLDCYDKEIMEIL--------- 669

  Fly   634 ANDLIIEFLSNHLEFFLRVEALSHLFQSQDQPFQQSALDYRLCINAVAVENDGDYNIIKDHLENY 698
             |:.:::.|...:|..||:...:||......||:....|..|..:...:.....:..|:.::.:|
Human   670 -NEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGMKDLALFFSLNPIRFFNRFIDIRAYVTHY 733

  Fly   699 FTATFYNLTTIAPHDWKSYEKMRHLANKVLQLQPIDDHLPNQIIDQGIDVLQIMRNIHTFASSYA 763
            ...|||||||:|.|||.:|.:||:||.:...|...:.|||:|.::||:|||:||||||.|.|.|.
Human   734 LDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYL 798

  Fly   764 YNMNLQVFVETNSRSKHLDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDEQI 828
            ||:|.|:|:|..|.:|||:.|..||:|||::||||||:||||||.||||::|||.||.|::||.|
Human   799 YNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHI 863

  Fly   829 KSRLLKELRFHTEHKHSKSYQSYPYERADSFLKKIRRLGCSSNGETYMDLFRKVITQVGNAVGYV 893
            ||||:|::||..|.|....:: ||::||:.|.:.||:||.:..|::|:|.||::|:|:|||:|||
Human   864 KSRLIKDIRFFREIKDQNDHK-YPFDRAEKFNRGIRKLGVTPEGQSYLDQFRQLISQIGNAMGYV 927

  Fly   894 RLLQAGSKNANFRNRSYKTRFDS------NFSCGGSKVHEATEGSIREYEKSLGHMKECYSD--- 949
            |::::|..:.:    |...||..      ||.   ..|.|  ||...|..|:..|:....||
Human   928 RMIRSGGLHCS----SNAIRFVPDLEDIVNFE---ELVKE--EGLAEETLKAARHLDSVLSDHTR 983

  Fly   950 ----STNYFKLLLQGFQPFLCNPHNHHLRTFYLITPALIMNYIDYRVKQKLKIYKKDQTKISLFE 1010
                .|.|||:|:..|.|....|.|.|||.||:|.|.|.:|::::.:..|.|:.||::...:..:
Human   984 NSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKIGAAFTD 1048

  Fly  1011 DGFAIGLVYILNMLNQQTEFHELGWSQTITQ-HLNAERSKVRDILAGQQRTAPEQLDEKLHQTVA 1074
            ||||:|:.|||.:|:|..||..|.|.|::.: :|...|:     :|.||.......||||.||:.
Human  1049 DGFAMGVAYILKLLDQYREFDSLHWFQSVREKYLKEIRA-----VAKQQNVQSASQDEKLLQTMN 1108

  Fly  1075 ITERHVNAYEHEYNLLYATLSSSEIFFQ 1102
            :|::.::.|..|:.|||.:|||:.|||:
Human  1109 LTQKRLDVYLQEFELLYFSLSSARIFFR 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SWIP	NP_573116.2	WASH-4_N	11..573	CDD:434178	131/621 (21%)
		WASH-7_mid	582..910	CDD:434177	135/351 (38%)
		WASH-7_C	929..1102	CDD:464293	66/180 (37%)
WASHC4	NP_001280569.1	WASH-4_N	32..601	CDD:434178	131/621 (21%)
		WASH-7_mid	606..950	CDD:434177	138/359 (38%)
		Sufficient for interaction with WASHC5. /evidence=ECO:0000269|PubMed:20498093	706..1174		187/446 (42%)
		WASH-7_C	967..1136	CDD:464293	63/173 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1143..1174