Protein Alignment SWIP and wshc-4

DIOPT Version :10

• Sequence 1: NP_573116.2
• Gene: SWIP / 32594
• FlyBaseID: FBgn0030739
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_497106.3
• Gene: wshc-4 / 190219
• WormBaseID: WBGene00013167
• Length: 1145
• Species: Caenorhabditis elegans
• Alignment Length: 1197
• Identity: 250/1197 - (20%)
• Similarity: 479/1197 - (40%)
• Gaps: 274/1197 - (22%)

  Fly    14 ISEHDGKLKLLRDKVPNRDVSESAQCVYMSPVVEVNFMGNDSMAPDRSFEESELVANKPLTTLAN 78
            ::|||...:..::|. .....|:.|...:|.::..          :..|.|:.:|      |:..
 Worm    29 LTEHDHITRFFKNKC-FAFADEAEQTAAISSLINC----------EDKFVEAYMV------TVGK 76

  Fly    79 LCNQCRN---LSRKAKRFQLAFLFSDFRLDDTLPPHTHTSEGSAGLEGS----LVRMSSSMDFFC 136
            :..:.|.   ...|..|....||.::..|.||   ..|.........|:    |:::.|.....|
 Worm    77 VYQESRKRVFAHYKNIRNMYLFLTAEESLMDT---DGHRINNLVAFIGNMYNCLLKLRSDALTLC 138

  Fly   137 QV--------YFLLNRMIVILQNLWRQIAASVSVPMDINEVHIFAVFDAMSELLEHI-VVFNELA 192
            :.        :|.|::. ...|.:|:.||         ..::.||..|.::.|...: :.|.:..
 Worm   139 EAIRQIKTSHFFPLHKS-ASFQRVWKHIA---------EIMYQFAAVDHLAALYPDLGIKFCDFQ 193

  Fly   193 NQSKISTMWALYKKWLMNLSNSQSANLELNGLSTSLMDIENLITK-DFFRIL-------LDNLM- 248
            .:.|        |.:.::.:.:|....:....:..  |.:::|.| :.||.|       :||.:
 Worm   194 KRIK--------KHFELDFTPAQRKAYDEGARAQE--DAQSMILKGNCFRTLYESSGGDMDNNLN 248

  Fly   249 ---ELKKQFG--LNS-----------------VSPIT----QHSNAYIRRQLLDVDANPSNELKN 287
               |:|:..|  |.|                 :|.:|    .|.:.::...|:......|.::..
 Worm   249 FANEMKEAIGDLLTSWEKTSAQGTTDGRFFCGISALTVYYYHHFSNFVDTSLIRKVVQASKKVPY 313

  Fly   288 YEDPKHIIRLTTFVVVVHELGIQMEGKLVKNVIDLVARHKQVPLNRSVFWSPSGFLSLHAKTLM- 351
            |.            ::..||.:.||  .::..|.          |:::|.|.:   .:.||.|:
 Worm   314 YR------------MLGEELFVPME--FLRREIS----------NKNIFDSKT---EIFAKKLVQ 351

  Fly   352 KSSARSQDGQGPKVH---------STVLEKFRLSDQRTCRQLGVQLSLWSIQMQRVF--DVGVFG 405
            ::|:.|:|.....:.         ||.:.:|: ..:|...:...:|..|.:.:..:|  .:.:..
 Worm   352 EASSISKDRADEMLKEVKEYCEHASTWMLEFQ-QKKRDQTEAITKLPQWGLDVSELFLKCIRILE 415

  Fly   406 HLKTFLQLILNGHSYADQVNLLAVALINRHVALMTPMTRNDWIVVSRLLQYLKVIQ-------KT 463
            .:...|.|::......|..|.:.:             .||....:.|.::.:|.::       .|
 Worm   416 TITRDLYLLIRSKRGEDHFNRIEI-------------DRNSAYAILRAIETVKRLELFVLDNWST 467

  Fly   464 FESNQINFVRFISSLIQWQKQKVIHLLHTTKKKIVVLKLLQRKINFLATIK----LAEKSIMG-- 522
            .|...     |::.. ||:|. ::.:|...:|..|..|.....:...||.:    :||...:.
 Worm   468 IEEGS-----FLARQ-QWRKH-MLRILSEARKSYVSSKSKNISVIEAATKRSFYHIAEAQCINEM 525

  Fly   523 FPSKQRLTFVNLALG-EFLDNRL---LPADNQKLIKSILHRVNSISDIMRNIGGQLNTSESSSLV 583
            .||:      |:.|| .:...||   :.:.|:|.::.:::|:.:.:. .|.:   |..:..:.|:
 Worm   526 IPSR------NVVLGLAYEIGRLETHISSPNRKQVQDLMNRLETFNS-PRQL---LQKAAFTGLL 580

  Fly   584 YNHWFLDTSVLKEYTELQRNPYSLQNLVSVSHHLDKIMAMFRGSRCPKQS-----------ANDL 637
            .:|.:|........|      |...::.|:......:.....|::...||           .|.|
 Worm   581 LSHSWLPHMYFDALT------YRKPDVESIEGFTSALGGFMEGAKITGQSMQILTKLKETIMNTL 639

  Fly   638 IIEFLSNHLEFFLRVEALSHLFQSQDQPFQQSALDYRLCINAVAVENDGDYNI------IKDHLE 696
            |:: :...::..||::|.:||...:.:  |..|.|..:......::....:.:      |.:.|.
 Worm   640 IVK-MGAQIDLDLRIQANTHLAVGKTE--QDGAPDEEMEYFGYLIKTVQKFQVATTVVPIAESLR 701

  Fly   697 NYFTATFYNLTTIAPHDWKSYEKMRHLANKVLQLQPIDDHLPNQIIDQGIDVLQIMRNIHTFASS 761
            ::....:|:|..:||::.|.|.:|:.:|.:...|..:|..||...||:.:.::.:::|...|.::
 Worm   702 SWLEEHWYSLEILAPNNAKVYTRMQQIAKRKYGLVLLDPDLPQSDIDETVAIMDLLQNFTHFVTN 766

  Fly   762 YAYNMNLQVFVETNSRSKHLDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDE 826
            |.|.....:|:|..|.||.|.:|.......:::.||.||:.|.:|..|||:|.|..||.:||.:|
 Worm   767 YCYFSQGYLFIEKASDSKKLHVIRLEDFKTALRKHGVGILPTAINAAYQFIRNKIQTFLSFLSEE 831

  Fly   827 QIKSRLLKELRFHTEHKHS---KSYQSYPYERADSFLKKIRRL-----------GCSSNG----- 872
            .::.::||.|.....:|.|   |....|....|.:.||.:.|.           |.|:||
 Worm   832 TVRCQVLKYLHEMEANKSSPDGKKKSQYKASWAANVLKNLARHQMVGAQGAHVGGGSTNGGSATA 896

  Fly   873 ---------ETYMDLFRKVITQVGNAVGYVRLL-QAGSKNANFRN------RSYKTRFDSNF--- 918
                     .||.|.||.:|||:|||:..||:| ||..:|...|.      :.|....:||.
 Worm   897 SAAAANEMLYTYFDKFRLIITQIGNAISLVRMLCQAARENGLTRQDLFPQVKKYMDDLESNTRSL 961

  Fly   919 ------SC--GGSKVHEATEGSIREYEKSLGHMKECY---SDSTNYFKLLLQGFQPFLCN---PH 969
                  .|  ..:|:|.|..         ||.:||.:   ::..||.|::...|:..|..   |.
 Worm   962 IFTNRPDCPINSTKMHAAYR---------LGLVKEMFERVAEHRNYTKMMCVEFKSLLMRSKLPE 1017

  Fly   970 N--HHLRTFYLITPALIMNYIDYRVKQKLKIYK----KDQTKISLFEDGFAIGLVYILNMLNQQT 1028
            :  ..|..|:.|.|||.:::|:|.:..:.::.|    |....:.:.:||||.|:.::|::.:...
 Worm  1018 DRVQVLDYFHGIIPALTLSHINYMMAHENRVKKTYALKHNKDLVVTDDGFAAGVAFLLHIFDGWD 1082

  Fly  1029 EFHELGW--SQTIT-QHLNAERSKVRD 1052
            .|.:|.|  |..|| :|....:|:.|:
 Worm  1083 SFFKLNWFDSYAITKEHEIRSQSESRE 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SWIP	NP_573116.2	WASH-4_N	11..573	CDD:434178	111/638 (17%)
		WASH-7_mid	582..910	CDD:434177	96/379 (25%)
		WASH-7_C	929..1102	CDD:464293	35/139 (25%)
wshc-4	NP_497106.3	WASH-4_N	51..499	CDD:434178	90/534 (17%)
		WASH-7_mid	580..945	CDD:434177	95/373 (25%)
		WASH-7_C	978..1127	CDD:464293	36/141 (26%)