Protein Alignment SWIP and SWIP

DIOPT Version :10

• Sequence 1: NP_573116.2
• Gene: SWIP / 32594
• FlyBaseID: FBgn0030739
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_308140.5
• Gene: SWIP / 1269498
• VectorBaseID: AGAMI1_013191
• Length: 1195
• Species: Anopheles gambiae
• Alignment Length: 1288
• Identity: 306/1288 - (23%)
• Similarity: 535/1288 - (41%)
• Gaps: 299/1288 - (23%)

  Fly     7 LRDYGSFISEHDGKL------KLLRDKVPNRDVSESAQCVYMSPVVEVNF-MGNDSMAPDRSFE- 63
            :::||.|:.::|.||      .|....||:              :|.::: ..|:.:.|.|..|
Mosquito    15 IKEYGHFLKDYDQKLAQLHLPALSNGPVPS--------------IVRLDYACNNERLPPARMIET 65

  Fly    64 --------------ESELVANKPLTTLANLCNQCRNLSRKAKR-----FQLAFLFSDFRLDDT-L 108
                          .|.|..||.|:|.|.||.:...|.::.:.     :.....|.|  ::|| .
Mosquito    66 NSINSGKSNSATPGTSTLPLNKLLSTFAQLCREIDCLEQEIRALVRTIYDRTEPFRD--VEDTDR 128

  Fly   109 PPHTHTSEGSAGLEGSLVRMSSSMDFFCQVYFLLNRMIVILQNLWRQIAA--------------- 158
            ||              |:.::.::|....|.....|:..:...|.|||.|
Mosquito   129 PP--------------LLWIAQNIDLMATVQCHYERLRDVGVLLLRQIGAFFDEEASYGRAKRTK 179

  Fly   159 -----SVSVP-MDINEVHIFAVFDAMSELLEHIVVFNELANQSKISTMWALYKKWLMNLSNSQSA 217
                 ..|.| :|::     .:||.:.:||...:..:.:..::.:...|..:...|...:.|..:
Mosquito   180 KNGLDGKSPPSLDVD-----YLFDYIGKLLRVALELDHIIGKTHLKAHWRSFAHKLRQPTKSAPS 239

  Fly   218 NLELNGLSTSLMDI-------------ENLITKDFFRILLDNLMELKKQFG-LNSVSPITQHSNA 268
            |      .....|:             |::......|.||:.|.::|.:|. :.|....:.....
Mosquito   240 N------KAGFRDLLFVCQAIGFWIGDESMPEVTGERRLLEALYKVKTRFDPVCSGEAFSDRFMK 298

  Fly   269 YIRRQLLDVDANPSNELK--NYEDPKHIIRLTTFVVVVHELGIQMEGKLVKNVIDLVARHKQVPL 331
            :::|:|.::.|:......  ::...|.:|.:...:.....|.:.:|.:::||:.:|..:...:||
Mosquito   299 FLKRKLTNLTASAKTTPNGVDFTQSKDVIGVNVLLNFALYLFLPIEQRMLKNLFELNLKFPLIPL 363

  Fly   332 NRSVFWSPSGFLSLHAKTLMK---SSARSQDGQGPKVHSTVLEKFR------LSDQRTCRQLGVQ 387
            ..:..|.|..|:.:|...|::   :||.......|...|...:|.|      |....|...|.:.
Mosquito   364 EDNFPWQPDEFIQVHGHKLLRDYDASAAPISVSTPLSTSFDYQKARDAQLQALEKSATAAVLCLH 428

  Fly   388 LSLWSIQMQRVF-----------DVGVF--GHLKTFLQLILNGHSYADQVNLL---AVALINRHV 436
            .:.|.::.....           |.|.|  ..|:....|:|.|.....::..:   ..||..|..
Mosquito   429 AASWLVEAHVQLRNRPPVPGASQDDGNFTLEKLRIKCGLLLEGVRLVREMEYVLGTLYALYGRRA 493

  Fly   437 ALMTPMTRNDWIVVSRLLQYLKVI-----QKTFESNQINFVRFISSLIQWQKQKVIHLLHTTKKK 496
            ...|          .||:||.:::     ..|..|..:..::||   :|.|:.|:..:::..|||
Mosquito   494 TERT----------DRLIQYRRMVVEFLLSSTRRSVTVPCLQFI---VQHQQHKIYTIVNNAKKK 545

  Fly   497 IVVLKLLQRK-----------INFLATIKLAEKSIMGFPSKQRLTFVNLAL----GEFLDN---- 542
            :    |.:.|           :..::||.:.||.:.|..:.:|:....|.:    |...:.
Mosquito   546 L----LREAKESKSSANGSLWLEKISTIDVLEKCLHGPATPERVGLAQLTIALCHGSASNGGPPL 606

  Fly   543 RLLPADNQKLIKSILHRVNSISDIMRNIGGQLNTSESSSLVYNHWFLDTSVLKEYTELQRNPYSL 607
            ..|..|..:.::|:|:|:.:..|..|         |.:.|         .|..:||.| ..|.:.
Mosquito   607 LALTDDAYRKVESLLNRLATFIDWER---------ECNRL---------DVAGKYTPL-LGPSAR 652

  Fly   608 QNLVSVSHHLDKIMAMFRGSRCPKQSANDLIIEFLSNHLEFFLRVEALSHLFQSQDQPF------ 666
            .:.:|||                        :..:||.:|.|:|.:  .|....|.:||
Mosquito   653 LDALSVS------------------------VVPMSNRIEAFIRWD--FHGKWHQIEPFDPFRDG 691

  Fly   667 ---------QQSALDYRLCINAVAVENDGDYNIIKDHLENYFTATFYNLTTIAPHDWKSYEKMRH 722
                     ....|.:......:..|.||.:...:..:.::.:..||.|:||:|.:|:.|.:||.
Mosquito   692 CDAAMGEQNHTQKLVFAFLRTKLTQEPDGRWLSARHSVAHHLSDVFYTLSTISPSEWRIYREMRS 756

  Fly   723 LANKVLQLQPIDDHLPNQIID---------QGIDVLQIMRNIHTFASSYAYNMNLQVFVE----- 773
            :.::...::.::|.||....:         |..|||.:|.:..||..||.|:::.|:|:|
Mosquito   757 IVDRKYGIRLVEDQLPRTTAEDRRGPRGHGQDDDVLALMEDFETFIGSYGYDLHGQLFIERQQAA 821

  Fly   774 ------TNSRSKHLDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDEQIKSRL 832
                  :.|....|:::...|:|||::.||.|||:|.||:.:||||||.:|||.||:||||.|||
Mosquito   822 TAASGGSTSGGGVLNVVKIEHIANSIKRHGPGIISTVVNYAFQFLRQKLFTFSHFLYDEQIHSRL 886

  Fly   833 LKEL-RFHTEHKHSK--------SYQSYPYERADSFLKKIRRLGCSSNGETYMDLFRKVITQVGN 888
            ..:. :..|:...|.        :..:|.|:||.:|.::||.||.|.:||||:|||||:|.|:||
Mosquito   887 AADAKKLATDSNDSAGTGASSGVNAANYTYDRALAFNRRIRNLGLSDDGETYVDLFRKLICQIGN 951

  Fly   889 AVGYVRLLQAGSKNANFRNRSYKTRFDSN--FSCGGSKVHEA------------TEGSIREYEKS 939
            |:.::|:|.||:    ....:....|.||  .:...|:.|:|            .:.::..:.:.
Mosquito   952 AMAFIRMLHAGA----LHECTGAAEFVSNPPTAAEASEHHQAPSSEPTLQSNPDNQSAVNIWRQD 1012

  Fly   940 LGHMKECYSDSTNYFKLLLQGFQPFLCNPHNH-------------HLRTFYLITPALIMNYIDYR 991
            :..::..:.....:|:|||..|.........|             ||..||||.|.|.::|::..
Mosquito  1013 MATVRTSWRLENEFFRLLLNAFDGLRRRRPTHADGESSAPADSFAHLELFYLIIPPLTISYVEAM 1077

  Fly   992 VKQKLKIYKKDQTKISL-FEDGFAIGLVYILNMLNQQTEFHELGWSQTITQHLNAERSKVRDILA 1055
            :|.|..|.|||:....| .:|||.:||.|:|.:|||...|:.|.|.:.:......|..|:....|
Mosquito  1078 LKAKETIAKKDRHGTFLPTDDGFVMGLSYLLTLLNQTAAFNSLHWFKEVHTKYAREMGKLNQQTA 1142

  Fly  1056 G------QQRTAPEQLDEKLHQTVAITERHVNAYEHEYNLLYATLSSSEIFFQ 1102
            |      ||.:..|..|||:..||::|.:.:||.:||:.||...||||:|||:
Mosquito  1143 GGTSNPLQQTSTMEPSDEKMLPTVSLTRKRLNAMQHEFELLQYNLSSSKIFFK 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SWIP	NP_573116.2	WASH-4_N	11..573	CDD:434178	127/675 (19%)
		WASH-7_mid	582..910	CDD:434177	110/371 (30%)
		WASH-7_C	929..1102	CDD:464293	60/192 (31%)
SWIP	XP_308140.5	None