Protein Alignment SWIP and washc4

DIOPT Version :10

• Sequence 1: NP_573116.2
• Gene: SWIP / 32594
• FlyBaseID: FBgn0030739
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: XP_004912961.2
• Gene: washc4 / 100379946
• XenbaseID: XB-GENE-5914213
• Length: 1171
• Species: Xenopus tropicalis
• Alignment Length: 1185
• Identity: 331/1185 - (27%)
• Similarity: 586/1185 - (49%)
• Gaps: 158/1185 - (13%)

  Fly     3 AEDILRDYGSFISEHDGKLKLLRDKVPNR--DVSESAQCVYMSPVVEVNFMGNDSMAPDRSFEES 65
            ||..|::||.|:.|:..:|:.:.:.:.:.  ||.:.:    :.|:..       .:.|   :|:|
 Frog    26 AEVQLKNYGKFLEEYTSQLRRIENALDDSIGDVWDFS----LDPIAL-------KLVP---YEQS 76

  Fly    66 EL---------VANKPLTTLANLCNQCRNLSRKAK-RFQLAFLFSDFRLDDTLPPHTHTSEGSAG 120
            .|         |.||.:|..|.||.:.:.|..:|: :|....||              ..||:|.
 Frog    77 SLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLF--------------YGEGAAE 127

  Fly   121 ---LEG-SLVRMSSSMDFFCQVYFLLNRMIVILQNLWRQIA----ASVSVP--MDINEVHIFAVF 175
               :|| |.::|...:.|..::...:.|...::.|:..|:|    ::.:.|  ::...||...::
 Frog   128 SSIVEGDSQIQMGRFISFLQELSCFVTRCYEVVMNVVHQLAGLYTSNRNEPKIIETTGVHFLTMY 192

  Fly   176 DAMSELLEHIVVFNE-LANQSKISTMWALYKKWLMNLSNSQSANLELNGLSTSLMDIENLITKDF 239
            :.:.|||..::..:| :.|.:.:...|.:||:.|.::.::..   :.......|...|.|:.| .
 Frog   193 EHLGELLTVLLTMDEIIENHATLKDHWTMYKRLLKSVHHNPG---KFGIQEDKLKPFEKLLLK-L 253

  Fly   240 FRILLDNLME---LKKQF-GLN---SVSPITQHSNAY---IRRQLLDVDANPSNELKNYEDPKHI 294
            ...|||.::.   :::|| .||   |||.....:..:   ||....:|:.. ..|....:..:..
 Frog   254 ESQLLDGMLFQGCVEQQFDSLNGGVSVSKNGTFAEEFAHNIRTIFSNVEVK-LGEASEIDQRERY 317

  Fly   295 IRLTTFVVVVHELGIQMEGKLVKNVIDLVARHKQVPLNRSVFWSPSGFL----SLHAKTLMKSSA 355
            :.|....|:..::...::.|..|::::...:...:.|..::.|....||    ...||.:.|.|.
 Frog   318 VGLCGLFVLYFQIFRTVDKKFYKSLLEACKKVPAITLTANIIWYADHFLIQKVPAAAKLIDKKSL 382

  Fly   356 RSQDGQGPKVHSTVLEKFRLSDQRTCRQLGVQLSLWSIQMQRV---------FDVGVFGHLKTFL 411
            ::...|    ..:.|:....|..:..:...|.:|.|.::|:.:         |...:......|:
 Frog   383 QAIKTQ----RDSYLQTKAQSLSKDVQSYYVFVSAWMMKMESILSKEQKAEKFAEDLTNRCNVFV 443

  Fly   412 QLILNGHSYADQVNLLAVALINRHVALMTPMTRNDWIVVSRLLQYLKVIQKTFESNQINFVRFIS 476
            |    |..||..::.:....:|.::::..|||:.....:.||::.||.|:.||....:.....:|
 Frog   444 Q----GFLYACGLSNIIKTTMNLYMSMQKPMTKTSVKALLRLVELLKAIEHTFHRRSMVVADSVS 504

  Fly   477 SLIQWQKQKVIHLLHTTKKKIVV-LKLLQRKINFLATIKLAEKSIMGFPSKQRLTFVNLALG--- 537
            .:.|..:.:.:..:...||:::. .|..:::::.|:.:.|||.::.|..::||...|:|||.
 Frog   505 HITQHLQHQALAAIAVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTRQRRLIVSLALSVGT 569

  Fly   538 ---EFLDNRLLPADNQKLIKSILHRVNSISDIMRNIGGQLNTSESSSLVYNHW-------FLDTS 592
               .|.|..|||      :..::.:::.||::...:..|.|      ..:.:|       :|| .
 Frog   570 QMKTFKDEELLP------LLLVMKKLDLISELRERVRSQCN------CCFLYWHRAVFPIYLD-D 621

  Fly   593 VLKEYTELQRNPYSLQNLVSV------SHHLD-----------KIMAMFRGSRCPKQSANDLIIE 640
            |.:...:..|..|....|.|.      :.||:           :|||:.          .:.:::
 Frog   622 VYENAVDASRLHYMFSALWSCVPDMMQARHLESYEVLLESYDKEIMAVM----------TEHLLD 676

  Fly   641 FLSNHLEFFLRVEALSHLFQSQDQPFQQSALDYRLCINAVAVENDGDYNIIKDHLENYFTATFYN 705
            .|...:|..||:...:||...:..||:....|.....:...:.....:..||..:.:|...||||
 Frog   677 ILCKEIEKDLRLSVHTHLQLDERNPFKIGMKDLAHFFSVKPIRFFHRFIDIKAFVTHYLDKTFYN 741

  Fly   706 LTTIAPHDWKSYEKMRHLANKVLQLQPIDDHLPNQIIDQGIDVLQIMRNIHTFASSYAYNMNLQV 770
            |||:|.|||.:|.:||:||.:...|...:.|||:|.::||:|||:||||||.|.|.|.||:|.|:
 Frog   742 LTTVALHDWATYSEMRNLATQRYGLTMTEPHLPSQTLEQGLDVLEIMRNIHVFVSRYLYNLNNQI 806

  Fly   771 FVETNSRSKHLDIIGTRHVANSVQTHGTGIINTTVNFIYQFLRQKFYTFSTFLHDEQIKSRLLKE 835
            |:|..|.:|||:.|..||:|||::||||||::|||||.|||||:|||.||.|::||.|||||:|:
 Frog   807 FIERTSNNKHLNTINIRHIANSIRTHGTGIMSTTVNFTYQFLRKKFYIFSQFMYDEHIKSRLIKD 871

  Fly   836 LRFHTEHKHSKSYQSYPYERADSFLKKIRRLGCSSNGETYMDLFRKVITQVGNAVGYVRLLQAGS 900
            :|:..|.| .::.|.||:|||:.|.:.||:||.:.:|::|:|.||::|:.:|||:||||::::|.
 Frog   872 IRYFREVK-DQNDQKYPFERAEKFNRGIRKLGLTPDGQSYLDQFRQLISHIGNAMGYVRMIRSGG 935

  Fly   901 KNANFRNRSYKTRFDS------NFS--CGGSKVHEATEGSIREYEKSLGHMKECYSDSTNYFKLL 957
            .:.    .|...||..      ||.  .....:.|.|:.:.|:.:..|..:....::.|.|||:|
 Frog   936 LHC----CSNAIRFVPDLEDIVNFEELVKEEGLSEETQKAARQLDSVLSDLTRNSAEGTEYFKML 996

  Fly   958 LQGFQPFLCNPHNHHLRTFYLITPALIMNYIDYRVKQKLKIYKKDQTKISLFEDGFAIGLVYILN 1022
            :..|.|...:..|.|||.||:|.|.|.:|::::.:..|.|:.||::...:..:||||:|:.|||.
 Frog   997 VDVFSPEFRSAKNIHLRNFYIIVPPLTLNFVEHSINCKEKLNKKNKVGAAFTDDGFAMGVAYILK 1061

  Fly  1023 MLNQQTEFHELGWSQTITQHLNAERSKVRDILAGQQRTAPEQLDEKLHQTVAITERHVNAYEHEY 1087
            :|:|..||..|.|.|::.:....|:..|    :.||.......||||.||:.:|::.::.|..|:
 Frog  1062 LLDQYQEFDSLHWFQSVREKYVKEKRAV----SKQQNVQSNNQDEKLLQTMNLTQKRLDIYLQEF 1122

  Fly  1088 NLLYATLSSSEIFFQ 1102
            .|||.:|||:.|||:
 Frog  1123 ELLYFSLSSARIFFR 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SWIP	NP_573116.2	WASH-4_N	11..573	CDD:434178	124/614 (20%)
		WASH-7_mid	582..910	CDD:434177	134/351 (38%)
		WASH-7_C	929..1102	CDD:464293	60/172 (35%)
washc4	XP_004912961.2	WASH-4_N	34..602	CDD:434178	124/614 (20%)
		WASH-7_mid	607..951	CDD:434177	137/359 (38%)
		WASH-7_C	968..1137	CDD:464293	60/172 (35%)