DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Had1 and cryl1

DIOPT Version :9

Sequence 1:	NP_001285320.1	Gene:	Had1 / 32592	FlyBaseID:	FBgn0286508	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001038806.1	Gene:	cryl1 / 751596	ZFINID:	ZDB-GENE-060810-7	Length:	315	Species:	Danio rerio

Alignment Length:	314	Identity:	154/314 - (49%)
Similarity:	217/314 - (69%)	Gaps:	4/314 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKNEK-VGIVGSGLIGRSWSMLFASVGYQVVLYDILPEQVSTALTATQKELQDLEAKGLLRGK 64
            ||:..|| :.:||||||||||:|:|.|.||:|.|||..|.|.|.|:...:|:|::|:...:|||.
Zfish     1 MSSLKEKIITVVGSGLIGRSWAMVFLSGGYKVKLYDNKPGQASGAIAEIRKQLEELQQAKMLRGN 65

  Fly    65 LTAAQQFACISGTNDLKELVKGAIFVQECIPERLDLKKALYKQLDAVVGPNTILSSSTSTFLPSL 129
            |:||:|.:.:|...||::.:.||.||||.:.|.|:.|::::..::.:|..:.|||||||..:||.
Zfish    66 LSAAEQLSRLSSHEDLQQALDGAFFVQESVFEDLEAKQSVFHAVEELVSESVILSSSTSCLMPSN 130

  Fly   130 FSADLKNKANVLVSHPVNPPYYVPLVEIVPAPWTKPEWVKKTRALMEEIGQKPVTLSREIEGFAL 194
            ..:.::|:...:|||||||||||.|||:||.|.|.|..::...:||.::||.||.|.:||:||||
Zfish   131 VFSQVQNRTRCIVSHPVNPPYYVRLVELVPHPETLPAVMEVAYSLMTDVGQAPVRLRKEIDGFAL 195

  Fly   195 NRIQYAILNETWRLVEAGILNVKDIDSVMSNGLGPRYAFLGPLETAHLNA-EGMANYFERYSNTI 258
            ||:||||:.|:||||:.|:::|||||.|||.|||.||||:||:||.|||| |||.:|.:|||..:
Zfish   196 NRVQYAIIAESWRLVQDGVISVKDIDLVMSEGLGMRYAFIGPIETMHLNAPEGMKDYLQRYSEGM 260

  Fly   259 YAVSETMGPTPKMEGPVAVEVAKQLGEMVP--LDQLAQRRNYRDNCLTQLSILK 310
            ..|..|.||.|...|..|..|.|::.|::|  .:.|:.||..||..|..|:.||
Zfish   261 KRVLNTFGPVPDFSGEPAARVIKEICELIPGKQEHLSARRERRDQLLMGLAKLK 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Had1	NP_001285320.1	PRK06129	7..310	CDD:235706	149/306 (49%)
		3HCDH_N	7..183	CDD:280833	80/176 (45%)
		3HCDH	191..>265	CDD:279114	47/74 (64%)
cryl1	NP_001038806.1	PRK06129	9..314	CDD:235706	148/304 (49%)
		3HCDH_N	9..187	CDD:280833	81/177 (46%)
		3HCDH	192..>262	CDD:279114	46/69 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581274
Domainoid	1	1.000	163	1.000	Domainoid score	I3924
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9322
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2725
OMA	1	1.010	-	-		QHG62303
OrthoDB	1	1.010	-	-		D462830at33208
OrthoFinder	1	1.000	-	-		FOG0006346
OrthoInspector	1	1.000	-	-		otm26613
orthoMCL	1	0.900	-	-		OOG6_105634
Panther	1	1.100	-	-	LDO	PTHR48075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3389
SonicParanoid	1	1.000	-	-		X4620
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940