DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Had1 and Cryl1

DIOPT Version :9

Sequence 1:	NP_001285320.1	Gene:	Had1 / 32592	FlyBaseID:	FBgn0286508	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_786933.1	Gene:	Cryl1 / 290277	RGDID:	631427	Length:	319	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	164/308 - (53%)
Similarity:	220/308 - (71%)	Gaps:	2/308 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VGIVGSGLIGRSWSMLFASVGYQVVLYDILPEQVSTALTATQKELQDLEAKGLLRGKLTAAQQFA 72
            |.|:|||||||||:|||||.|::|.||||..:|::.||.:.:||::.||..|.|:|.|.|.||.:
  Rat     9 VVIIGSGLIGRSWAMLFASGGFKVKLYDIEQQQITNALESIRKEMKSLEQSGSLKGSLGAEQQLS 73

  Fly    73 CISGTNDLKELVKGAIFVQECIPERLDLKKALYKQLDAVVGPNTILSSSTSTFLPSLFSADLKNK 137
            .|||..:|.|.|:||:.:|||:||.|:|||.::.|||.:|....|||||:|..|||.....|.:.
  Rat    74 LISGCGNLAEAVEGAMHIQECVPENLELKKKIFAQLDRIVDDQVILSSSSSCLLPSKLFTGLAHV 138

  Fly   138 ANVLVSHPVNPPYYVPLVEIVPAPWTKPEWVKKTRALMEEIGQKPVTLSREIEGFALNRIQYAIL 202
            ...:|:|||||||||||||:||.|.|.|..:.:|.|||::|.|.||.:.:||:||.|||:||||:
  Rat   139 KQCIVAHPVNPPYYVPLVELVPHPETAPATMDRTYALMKKIRQTPVRVLKEIDGFVLNRLQYAII 203

  Fly   203 NETWRLVEAGILNVKDIDSVMSNGLGPRYAFLGPLETAHLNAEGMANYFERYSNTIYAVSETMGP 267
            :|.|||||.||::..|:|.|||:|||.||||:|||||.|||||||.:|.:|||..:..|.:|.||
  Rat   204 SEAWRLVEEGIVSPNDLDLVMSDGLGMRYAFIGPLETMHLNAEGMVSYCDRYSEGMKRVLKTFGP 268

  Fly   268 TPKMEGPVAVEVAKQLGEMVPLD--QLAQRRNYRDNCLTQLSILKNKL 313
            .|:..|....:|.:.:...||.|  .||.||::||:||.|||.||:::
  Rat   269 VPEFSGDTVEKVNQDMCMKVPDDPEHLAARRHWRDDCLMQLSKLKHQM 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Had1	NP_001285320.1	PRK06129	7..310	CDD:235706	162/303 (53%)
		3HCDH_N	7..183	CDD:280833	92/174 (53%)
		3HCDH	191..>265	CDD:279114	46/73 (63%)
Cryl1	NP_786933.1	PRK06129	9..314	CDD:235706	163/304 (54%)
		3HCDH_N	9..186	CDD:280833	94/176 (53%)
		3HCDH	192..>261	CDD:279114	45/68 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341332
Domainoid	1	1.000	186	1.000	Domainoid score	I3260
eggNOG	1	0.900	-	-		E1_COG1250
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9322
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2423
OMA	1	1.010	-	-		QHG62303
OrthoDB	1	1.010	-	-		D462830at33208
OrthoFinder	1	1.000	-	-		FOG0006346
OrthoInspector	1	1.000	-	-		otm44761
orthoMCL	1	0.900	-	-		OOG6_105634
Panther	1	1.100	-	-	LDO	PTHR48075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4620
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770