Protein Alignment CG3632 and MTMR4

DIOPT Version :9

• Sequence 1: NP_001096996.1
• Gene: CG3632 / 32589
• FlyBaseID: FBgn0030735
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001364996.1
• Gene: MTMR4 / 9110
• HGNCID: 7452
• Length: 1209
• Species: Homo sapiens
• Alignment Length: 1364
• Identity: 449/1364 - (32%)
• Similarity: 624/1364 - (45%)
• Gaps: 351/1364 - (25%)

  Fly    16 PPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLS-KQSTGY 79
            |||:.:|:|.:.:|..::.||:..|.|||..|.||.:::|||..|.::|:||||:.:. |.|.
Human    20 PPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSV-- 82

  Fly    80 ETYVPLGLIESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPF 144
             ..|||.:|:||:.||:|||.::|||:..|||.|.:.:||.:|..|:......|...|.||||.:
Human    83 -INVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAY 146

  Fly   145 YSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMS 209
            ::|..                   ||..:|:    |..|.:|..::..
Human   147 HAWCL-------------------GLTEEDQ----HTHLCQPGEHIRC----------------- 171

  Fly   210 NRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFR 274
                   |.|:    |:||:||||:..||:|..|:::|||||||.|||||..|||:.|.|||:||
Human   172 -------RQEA----ELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFR 225

  Fly   275 GSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAK 339
            ..:|:|.||:||.::||.:|||||||:.|.||||..||.|:.::|.|||.|.|..|
Human   226 SWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRA--------- 281

  Fly   340 AQPTKGSKETNGQSGLSGKSSPSLDDS----SHEELTLDEIKKILIVDARSYTSAVTNRARGGGC 400
               |.||..| |.:..|.......|.|    |..|.|... :|:||:||||||:||.|||:||||
Human   282 ---TGGSLST-GNNDTSEACDADFDSSLTACSGVESTAAP-QKLLILDARSYTAAVANRAKGGGC 341

  Fly   401 ECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTV 465
            ||.||||..|:.||.:.||||||.||..:|.:|:..||..||...||.|.|:||||.:|.|.:.|
Human   342 ECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLV 406

  Fly   466 VHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNG 530
            .:|:::.||||||||||||||||||||.|::.|||||||:|||:||||.:||:|||||.||.|:.
Human   407 ANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQ 471

  Fly   531 PNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENS 595
            .|.::.||:|||||||||.|||:.:|:||.|||:.::|:||.||:.|||:||||.|:..||.:.:
Human   472 ENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRN 536

  Fly   596 VFDRTFSVWPFL--AETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLG-----SLGNKNGTDL 653
            ::.||.|||..|  ....:.|.||...::.||.|...||.|:.|:.|||.     :||.:| .||
Human   537 IYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEEN-MDL 600

  Fly   654 ---PLLSNERQSGHN-GLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMF 714
               |:..::..||.: ..:.||||.:||.:.....|.::|.||||||             :|...
Human   601 YLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNL-------------NNHCQ 652

  Fly   715 DIR--SEANNSVSENVQESVKDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQSTASKRDILEVE 777
            ::|  .|..:|..|..:.|..||.......|    ||..|.. .|:|        :|::|.|..:
Human   653 EVRVGLEPWHSNPEGSETSFVDSGVGGPQQT----VGEVGLP-PPLP--------SSQKDYLSNK 704

  Fly   778 SQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQS 842
                                            |.:|.:|.:.|.||              .|...
Human   705 --------------------------------PFKSHKSCSPSYKL--------------LNTAV 723

  Fly   843 PVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHI------------TSPTME 895
            |..:||               .||...:...|..:.|..|.|::|.:            ..|..|
Human   724 PREMKS---------------NTSDPEIKVLEETKGPAPDPSAQDELGRTLDGIGEPPEHCPETE 773

  Fly   896 LVSGDRKLESTSTVQASKISQSYNNLP-------------------------KVHIRPNAVICPQ 935
            .||...|:.|..........:|..|.|                         .....|.:..|..
Human   774 AVSALSKVISNKCDGVCNFPESSQNSPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQT 838

  Fly   936 RVD---------------AFPHHLDL-QVPRETTGNPDRCKPEKLAKDANANANANGSLLASDGY 984
            .:|               :..|...| .||..|.|..|      :.|..|   |.||.||.:
Human   839 PLDPSTDFLNQDPSGSVASISHQEQLSSVPDLTHGEED------IGKRGN---NRNGQLLEN--- 891

  Fly   985 NGEESLFISPDLQRFVGQSPFDAPSTGGRIRRNTFGSSYSRDMKFTAEN-----GSAHQFPSS-- 1042
                        .|| |:.|.:       :.|.....|...:..|...|     |....|||.
Human   892 ------------PRF-GKMPLE-------LVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEA 936

  Fly  1043 --------GIISLPPTPFQERA------------------------------------------- 1056
                    |..|..|...|.||
Human   937 TPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVKSPVCSSHSNGHCTGPGGKNQMWLSSHP 1001

  Fly  1057 -------QFTISCP----------DGLAHGLSEQNIRLHQIVQEHKLREEMLLREIHGMRLALLE 1104
                   ...::||          |||.........||.||...:|...|.|.|::..:::.|..
Human  1002 KQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDI 1066

  Fly  1105 KGCPSCNSIVSTNMEHE---------NGSDIVENASTCSWEAVEERSGPASYAPSSIQEKKASSV 1160
            :.|  |.......|::|         :|||..:..|..|.:.:.|    ||:.|  :.:|:....
Human  1067 RHC--CAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSE----ASWEP--VDKKETEVT 1123

  Fly  1161 LWVPDHAVSRCSSCQTEFWLGRRKHHCRSCGEIFCADCSEFWAPLPNEKLFNPVRLCGSCYTSV 1224
            .|||||..|.|.:|..||||.:|:||||:||.:|||.|.....|:|:::|::||.:|.|||..:
Human  1124 RWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHI 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	48/112 (43%)
		Myotub-related	221..590	CDD:284109	205/372 (55%)
		FYVE_MTMR4	1162..1221	CDD:277272	30/58 (52%)
MTMR4	NP_001364996.1	PH-GRAM_MTMR4	37..150	CDD:270150	48/115 (42%)
		PTP-MTMR4	186..493	CDD:350435	177/320 (55%)
		FYVE_MTMR4	1125..1184	CDD:277272	30/58 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155566
Domainoid	1	1.000	454	1.000	Domainoid score	I506
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	675	1.000	Inparanoid score	I728
Isobase	1	0.950	-	0	Normalized mean entropy	S3513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	1	1.000	-	-		FOG0004824
OrthoInspector	1	1.000	-	-		otm40420
orthoMCL	1	0.900	-	-		OOG6_105196
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2890
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710