DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and MTMR6

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001372159.1	Gene:	MTMR6 / 9107	HGNCID:	7453	Length:	659	Species:	Homo sapiens

Alignment Length:	737	Identity:	205/737 - (27%)
Similarity:	322/737 - (43%)	Gaps:	147/737 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ESIKYLGRTD------DGILAL-SNYRIFLSKQSTGYETYVPLGLIESVQVRDL----FQLIVNC 103
            |.:|.|.|..      .|.|.| :.:.:|:.....  ||::....|.||:...|    ..|::.|
Human    10 EQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQK--ETWILHHHIASVEKLALTTSGCPLVIQC 72

  Fly   104 KDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGN 168
            |:..||....|....|.|....: |.:......|.|:||.:
Human    73 KNFRTVHFIVPRERDCHDIYNSL-LQLSKQAKYEDLYAFSY------------------------ 112

  Fly   169 GLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQ--RSVRYESDFKNEVARLGF 231
                                     ||..:.         |.|||  :.:    |...|..|:|.
Human   113 -------------------------NPKQND---------SERLQGWQLI----DLAEEYKRMGV 139

  Fly   232 DLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARC 296
            . ...|::|.||.|:|:|.:||.:|.||...:..::...:.||...|.|.:.:.||...|.:.||
Human   140 P-NSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRC 203

  Fly   297 SQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSP 361
            |||..|:.. |...||.||:|::.|...:|..:.. .|....:.|....:::..|:..:...|..
Human   204 SQPLSGFSA-RCLEDEHLLQAISKANPVNRYMYVM-DTRPKRRMQSWWATQKDIGRIIVRISSKI 266

  Fly   362 SLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSF 426
            ..|:...|.   :|.|::         :|:.|||.|.|.|..:.|.....:|:.:.|||.:|.|.
Human   267 QNDEKIRES---NEKKRL---------NAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSL 319

  Fly   427 HAVRQLCASSPDDPN-WYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQI 490
            ..:.::..:.....| :|..||.:.|::|:..::.|.:.:...|......||||||||||||.|:
Human   320 QKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQV 384

  Fly   491 VATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHR 555
            .:...|.||.||||::||.||:|::|::|||||::|.|.  ...:..|..|||.|:|:.|..:..
Human   385 CSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQ--LDGDPKEVSPVFTQFLECVWHLTE 447

  Fly   556 QYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPLYK 618
            |:|.:||||.::|:::.:|..||.||.||.|..:||.|..:.::|:|:||||.|..  |.||||.
Human   448 QFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYS 512

  Fly   619 HETEK--VLWPAHSVRFLY-FWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLM------------ 668
            .|:.:  ||.| ::|.|.: ||.::|       :..|..|  :.|||..|.:|
Human   513 SESHRFTVLEP-NTVSFNFKFWRNMY-------HQFDRTL--HPRQSVFNIIMNMNEQNKQLEKD 567

  Fly   669 ----------AKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNAN-----SNSMFDIR- 717
                      .|.:.::.:.|.||..|.   ....|||....    ||...     ::::..|.
Human   568 IKDLESKIKQRKNKQTDGILTKELLHSV---HPESPNLKTSL----CFKEQTLLPVNDALRTIEG 625

  Fly   718 -SEANNSVSENVQESVKDSKEV 738
             |.|:|..||..:|..|....|
Human   626 SSPADNRYSEYAEEFSKSEPAV 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	27/107 (25%)
		Myotub-related	221..590	CDD:284109	122/369 (33%)
		FYVE_MTMR4	1162..1221	CDD:277272
MTMR6	NP_001372159.1	PH-GRAM_MTMR6	1..101	CDD:270151	23/93 (25%)
MTMR6	NP_001372159.1	PTP_DSP_cys	130..469	CDD:421693	114/355 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850