DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3632 and MTMR2

DIOPT Version :9

Sequence 1:NP_001096996.1 Gene:CG3632 / 32589 FlyBaseID:FBgn0030735 Length:1250 Species:Drosophila melanogaster
Sequence 2:NP_057240.3 Gene:MTMR2 / 8898 HGNCID:7450 Length:643 Species:Homo sapiens


Alignment Length:735 Identity:221/735 - (30%)
Similarity:336/735 - (45%) Gaps:168/735 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IHTMSDGSPPPSICFIRAAESY-PKSQMEKEDSQLFVPFQE---LAGESIKYLGR---------- 57
            :||.| .|...|.....:|::: |..::.:|.::| ...:|   |.||:||.:.:          
Human    37 VHTKS-ASVVSSDSISTSADNFSPDLRVLRESNKL-AEMEEPPLLPGENIKDMAKDVTYICPFTG 99

  Fly    58 TDDGILALSNYRIFLS--KQSTGYETYVPLGLIESVQV--------RDLFQLIVNCKDASTVRCS 112
            ...|.|.::|||::..  ::...:.....||:|..|:.        .:.:.|...|||...:|  
Human   100 AVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLR-- 162

  Fly   113 FPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCL 177
              .|.:.....||     .:.|:| ..:|||                                  
Human   163 --FAHKPEGRTRR-----SIFENL-MKYAFP---------------------------------- 185

  Fly   178 TLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDLKG----SWR 238
                          .||.||..|.|          .:.|..|:.:|.....|.:..:|    |||
Human   186 --------------VSNNLPLFAFE----------YKEVFPENGWKLYDPLLEYRRQGIPNESWR 226

  Fly   239 ISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGW 303
            |:..|..::||.:||..|:||..|.||.|..||:||...|:|.:.|.|.:|.|.:.|||||.||.
Human   227 ITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGV 291

  Fly   304 LGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSH 368
            .|.|:..||:.|:|:.|                            :|.||               
Human   292 SGKRSKEDEKYLQAIMD----------------------------SNAQS--------------- 313

  Fly   369 EELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLC 433
                    .||.|.|||...:||.|:|:|||.|..:.|..||:.|:::.|||.:|:|...::::.
Human   314 --------HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIV 370

  Fly   434 ASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCL 498
            ..:.::.:|...||.|.|::|:..:|...:.:...:|.....|:||||||||||.|:.:.|.|.|
Human   371 YPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLML 435

  Fly   499 DPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEF 563
            |.||||:.||.||||:|||:|||:|..|.|:|..:....:|.|||||::|.|.|:.||:|.:|||
Human   436 DGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEF 500

  Fly   564 SISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPLYKHETEKVLW 626
            :..:||.:..|..|||||||||||.::|.:.::..||.|:|.::...:  :.||||...:..||:
Human   501 NEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLY 565

  Fly   627 PAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHN---GLMAK----TRSSEDLTTNELGQ 684
            |..|:|.|..|...|:    ..|....|     ::..||   .|:||    .:..|:|......:
Human   566 PVASMRHLELWVGYYI----RWNPRMKP-----QEPIHNRYKELLAKRAELQKKVEELQREISNR 621

  Fly   685 ST-ISRRSSDPNLTVESIVT 703
            || .|.|:|.|...|..:.|
Human   622 STSSSERASSPAQCVTPVQT 641

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG3632NP_001096996.1 PH-like 35..147 CDD:302622 30/134 (22%)
Myotub-related 221..590 CDD:284109 142/372 (38%)
FYVE_MTMR4 1162..1221 CDD:277272
MTMR2NP_057240.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 6/19 (32%)
PH-like 73..187 CDD:388408 28/171 (16%)
Myotub-related 192..528 CDD:368997 146/396 (37%)
Substrate binding. /evidence=ECO:0000269|PubMed:14690594 330..333 1/2 (50%)