DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and MTMR1

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_005274822.1	Gene:	MTMR1 / 8776	HGNCID:	7449	Length:	699	Species:	Homo sapiens

Alignment Length:	704	Identity:	200/704 - (28%)
Similarity:	318/704 - (45%)	Gaps:	168/704 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EKEDSQLFVPFQELAGESIK-----------YLGRTDDGILALSNYRIFLS--KQSTGYETYVPL 85
            :.|::.||      .|||||           ::|.. .|.|.:::::::..  ::...:...|||
Human   128 QMEEAPLF------PGESIKAIVKDVMYICPFMGAV-SGTLTVTDFKLYFKNVERDPHFILDVPL 185

  Fly    86 GLIESVQV-------RDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFP 143
            |:|..|:.       .:...:.:.|||...:|.::...||..         :|:.|:|.. .|||
Human   186 GVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQSK---------LGIFENLNK-HAFP 240

  Fly   144 FYSWTCDVLGSGNGSGIVSAQANGNGLIA---KDRCLTLHNGLAKPTANVTASNPLPDPASETIS 205
            .                    :||..|.|   |::...  ||.           .:.||.||...
Human   241 L--------------------SNGQALFAFSYKEKFPI--NGW-----------KVYDPVSEYKR 272

  Fly   206 AAMSNRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNV 270
            ..:.|.                        ||:||..|::::.|.:||..::||..:.|:.|..|
Human   273 QGLPNE------------------------SWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKV 313

  Fly   271 ANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTC 335
            |.||...|:|.:.|.|.:|.|.:.|||||.||....|...||:.|:.:.||
Human   314 AAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDA-------------- 364

  Fly   336 ANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGC 400
                          |.||                       .|::|.|||..:.|.||:.:|||.
Human   365 --------------NAQS-----------------------HKLIIFDARQNSVADTNKTKGGGY 392

  Fly   401 ECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTV 465
            |....||.||:.|:.:.|||.:|:|...::::...|.|:..|...::.|.|::::..||...:.:
Human   393 ESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRMLLAGAVRI 457

  Fly   466 VHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNG 530
            ...||.....|:||||||||||.|:.:.|.|.||.||||::||..|||:||::|||:||.|.|:|
Human   458 ADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHG 522

  Fly   531 PNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENS 595
            .::....:|.|:|||::|.|.|:.||:|.:|||:..:||.:..|..||||||||||..::|.:..
Human   523 NDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKED 587

  Fly   596 VFDRTFSVWPFLAETM--YRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSN 658
            |:.:|.|:|.::...:  :.||.:.:....||:|..|:..|..|.:.|: ....:....:|:..|
Human   588 VYTKTISLWSYINSQLDEFSNPFFVNYENHVLYPVASLSHLELWVNYYV-RWNPRMRPQMPIHQN 651

  Fly   659 ---------ERQSGHNGLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVT 703
                     |.|....||      ..::.|..:..|  |.|.|.|:.:..|:.|
Human   652 LKELLAVRAELQKRVEGL------QREVATRAVSSS--SERGSSPSHSATSVHT 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	29/131 (22%)
		Myotub-related	221..590	CDD:284109	131/368 (36%)
		FYVE_MTMR4	1162..1221	CDD:277272
MTMR1	XP_005274822.1	PH-GRAM_MTMR1	141..240	CDD:270165	20/109 (18%)
MTMR1	XP_005274822.1	Myotub-related	247..582	CDD:284109	141/422 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155572
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750