Protein Alignment CG3632 and SBF2

DIOPT Version :10

• Sequence 1: NP_001096996.1
• Gene: CG3632 / 32589
• FlyBaseID: FBgn0030735
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001373268.1
• Gene: SBF2 / 81846
• HGNCID: 2135
• Length: 1881
• Species: Homo sapiens
• Alignment Length: 1096
• Identity: 268/1096 - (24%)
• Similarity: 418/1096 - (38%)
• Gaps: 283/1096 - (25%)

  Fly     2 DFMVPIHTMSDGSPPPSI----CFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYL----GRT 58
            |.:..:|.|..|.....|    ...|.:...|..|..|......:|.:|:..|.::.|    ||.
Human   835 DHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGRE 899

  Fly    59 D--------------DGILALSNYRIFL----SKQSTGYETYV---PLGLI-------------- 88
            :              :|.|.|:.|||..    ..|..|.:|.|   |:..|
Human   900 EATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQ 964

  Fly    89 ---ESVQVRDL-FQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTC 149
               |.:|:... ||||....|...      |.|....::::: :....|:|:.:.|||.....|.
Human   965 NMQEGLQITSASFQLIKVAFDEEV------SPEVVEIFKKQL-MKFRYPQSIFSTFAFAAGQTTP 1022

  Fly   150 DVL-----------GSGNGSGIVSAQANGNGLIAKDRCLTLHNG------LAKPTAN----VTAS 193
            .::           .:.:.:.:..|:..|...|.:...|....|      :.:|..|    |:.|
Human  1023 QIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVS 1087

  Fly   194 NPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGF-DLKGS--------WRISTANADFKLC 249
            :....|.|.|:.|:..:.:::.|  |.....:..|||. .:.||        :||:.:|..:.||
Human  1088 DESELPTSTTLKASEKSTMEQLV--EKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLC 1150

  Fly   250 PSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARC----SQPEVGWLGWRNT- 309
            .|||..|:||..:.|..|..||......|||.|.|::.:||.:|.|.    .:..||....:|:
Human  1151 RSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSP 1215

  Fly   310 --------------RDEQLLKALADAC------------------AFDRGEHARHSTCANAKAQP 342
                          ..|:.|:||.:|.                  |...|...|.|..:....|.
Human  1216 QAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGTERRTSRMSTVLKQV 1280

  Fly   343 TKGSKETN-----GQSG------------------------LSGKS-SPSLDDSSHEELTLDEIK 377
            ..|..:.|     .|.|                        |:||. |.|..:||:.:      .
Human  1281 VPGHLDVNPSNSFAQGGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQ------N 1339

  Fly   378 KILIVDARSYTSAVTNRARGGGCE----CIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSP- 437
            ::|...|..|.....::.|....|    | |:.|   :||   ..|..::.||..:.:.|..|.
Human  1340 QLLKRQAALYIFGEKSQLRNFKVEFALNC-EFVP---VEF---HEIRQVKASFKKLMRACIPSTI 1397

  Fly   438 ------------DDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQI 490
                        .|..|:.||.:.|.:          ..||..:.:||..|||...:|||.|.|:
Human  1398 PTDSEVTFLKALGDSEWFPQLHRIMQL----------AVVVSEVLENGSSVLVCLEEGWDITAQV 1452

  Fly   491 VATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRS-------GNGPNSDEVNERCPVFLQWLD 548
            .:..||..||:|||:|||::|||:|||:|||||:.||       |:|        ..|||||:||
Human  1453 TSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSG--------FAPVFLQFLD 1509

  Fly   549 LVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN-SVFD--------RTFSVW 604
            .|||:|.|||..|||::.||..||.|.:|..|.|||.:|..||:|: ::||        :...:|
Human  1510 CVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIW 1574

  Fly   605 PFLAETMYRNP-----LYKHETEKVLWPAHSVRFLYFWSDVYL-GSLGNKNGTDLPLLSNERQSG 663
            ..:.....|:|     ||.....:.|.|..:|..|..| |.|: .:|......|..:|:
Human  1575 ECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKW-DYYIEETLSTGPSYDWMMLT------ 1632

  Fly   664 HNGLMAKTRSSEDL-TTNELGQSTISRRS-----SDPNLTVESIVTDCFNANSNSMFDIRSEANN 722
                 .|...|||. ...|.|..: .||:     .|.:.|....:|..|     |..:......|
Human  1633 -----PKHFPSEDSDLAGEAGPRS-QRRTVWPCYDDVSCTQPDALTSLF-----SEIEKLEHKLN 1686

  Fly   723 SVSENVQESVKDSKEVELDVTDATEVGPCGRSNNP------IPDFHNDQSTASKRDILEVESQT- 780
            ...|..|: :.:...|:|.....|:......|.:|      :|.:       .||.:|.:...:
Human  1687 QAPEKWQQ-LWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSY-------QKRSLLHLPDSSM 1743

  Fly   781 --QRRSSLESSQLI---PGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRP-FFIFGSSEN 839
              ::.||:..|..:   ..:::...:|:||:|    .|.|.....:....:..:| :|:...:::
Human  1744 GEEQNSSISPSNGVERRAATLYSQYTSKNDEN----RSFEGTLYKRGALLKGWKPRWFVLDVTKH 1804

  Fly   840 DQSPVPLKSEDTSDISRALWHGAIE-TSTDTLIPAEP---VQKPNSDNSSRDHITS 891
             |.......||||      ..|.|: ...:.:|||.|   ..|..||.:..|..||
Human  1805 -QLRYYDSGEDTS------CKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTS 1853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:473070	33/154 (21%)
		Myotub-related	221..591	CDD:461958	138/469 (29%)
		FYVE_MTMR4	1162..1221	CDD:277272
SBF2	NP_001373268.1	uDENN	1..86	CDD:214824
		DENN	116..298	CDD:460461
		dDENN	352..420	CDD:129037
		SBF2	530..754	CDD:463536
		PH-GRAM_MTMR13	882..1000	CDD:275416	26/123 (21%)
		PTP-MTMR13	1138..1517	CDD:350437	116/409 (28%)
		Required for homodimerization and interaction with MTMR2. /evidence=ECO:0000250|UniProtKB:E9PXF8, ECO:0000269|PubMed:15998640	1661..1714		11/58 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1706..1726		3/19 (16%)
		PH_Sbf1_hMTMR5	1774..1879	CDD:269941	22/91 (24%)