DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Mtmr2

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_036011299.1	Gene:	Mtmr2 / 77116	MGIID:	1924366	Length:	718	Species:	Mus musculus

Alignment Length:	736	Identity:	218/736 - (29%)
Similarity:	336/736 - (45%)	Gaps:	163/736 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IHTMSDGSPPPSICFIRAAESY-PKSQMEKEDSQLFVPFQE---LAGESIKYLGR---------- 57
            :||.| .|...|.....:|::: |..::.:|.::| ...:|   |.||:||.:.:
Mouse   105 VHTKS-ASAISSDSISTSADNFSPDLRVLREANKL-AEMEEPALLPGENIKDMAKDVTYICPFTG 167

  Fly    58 TDDGILALSNYRIFLS--KQSTGYETYVPLGLIESVQV--------RDLFQLIVNCKDASTVRCS 112
            ...|.|.:::||::..  ::...:.....||:|..|:.        .:.:.|...|||...:|
Mouse   168 AVRGTLTVTSYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLR-- 230

  Fly   113 FPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKD-RC 176
              .|.:.....||     .:.|:| ..:|||.                    :||..|.|.: :.
Mouse   231 --FAHKPEGRTRR-----SIFENL-MKYAFPV--------------------SNGLPLFAFEYKE 267

  Fly   177 LTLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDLKGSWRIST 241
            :...||.           .|.||..|.....:.|.                        ||||:.
Mouse   268 VFPENGW-----------KLYDPLLEYRRQGIPNE------------------------SWRITK 297

  Fly   242 ANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGWLGW 306
            .|..::||.:||..|:||..|.||.|..||:||...|:|.:.|.|.:|.|.:.|||||.||..|.
Mouse   298 INERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGK 362

  Fly   307 RNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSHEEL 371
            |:..||:.|:|:.|                            :|.||
Mouse   363 RSKEDEKYLQAIMD----------------------------SNAQS------------------ 381

  Fly   372 TLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASS 436
                 .||.|.|||...:||.|:|:|||.|..:.|..||:.|:::.|||.:|:|...::::...:
Mouse   382 -----HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPT 441

  Fly   437 PDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPY 501
            .::.:|...||.|.|::|:..:|...:.:...:|.....|:||||||||||.|:.:.|.|.||.|
Mouse   442 IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGY 506

  Fly   502 YRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHR-------QYPC 559
            |||:.||.||||:|||:|||:|..|.|:|..:....:|.|||||::|.|.|:.|       |:|.
Mouse   507 YRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFVVLNLQFPT 571

  Fly   560 SFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPLYKHETE 622
            :|||:..:||.:..|..|||||||||||.::|.:.::..:|.|:|.::...:  :.||||...:.
Mouse   572 AFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLYGSYSN 636

  Fly   623 KVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHNGLMAK----TRSSEDLTTNELG 683
            .||:|..|:|.|..|...|: ....:.....|:.|..::     |:||    .|..|:|......
Mouse   637 HVLYPVASMRHLELWVGYYI-RWNPRMKPQEPIHSRYKE-----LLAKRAELQRKVEELQREISN 695

  Fly   684 QST-ISRRSSDPNLTVESIVT 703
            :|| .|.|:|.|...|..:.|
Mouse   696 RSTSSSERASSPAQCVTPVQT 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	29/134 (22%)
		Myotub-related	221..590	CDD:284109	139/375 (37%)
		FYVE_MTMR4	1162..1221	CDD:277272
Mtmr2	XP_036011299.1	PH-like	141..255	CDD:418428	27/143 (19%)
Mtmr2	XP_036011299.1	Myotub-related	270..603	CDD:399535	146/418 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750