DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and Sbf2

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_008758019.1	Gene:	Sbf2 / 691042	RGDID:	1588657	Length:	1904	Species:	Rattus norvegicus

Alignment Length:	1113	Identity:	242/1113 - (21%)
Similarity:	380/1113 - (34%)	Gaps:	420/1113 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RAAESYPKSQMEKEDSQLFVPFQELAGESIKYL----GRTD--------------DGILALSNYR 69
            |.:...|..|..|......:|.:|:..|.::.|    ||.:              :|.|.|:.||
  Rat   858 RESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYR 922

  Fly    70 IFL----SKQSTGYETYV---PLGLI-----------------ESVQVRDL-FQLIVNCKDASTV 109
            |..    ..|..|.:|.|   |:..|                 |.:|:... ||||....|...
  Rat   923 ILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAFDEEV- 986

  Fly   110 RCSFPSAEQCSDWQRRIHLMIGVPESLETLFAF-------------------PFYSWTCDVLGSG 155
                 |.|....::::: :....|:|:.:.|||                   .|.:::..::...
  Rat   987 -----SPEVVDIFKKQL-MKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGA 1045

  Fly   156 NGSG----------------IVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETI 204
            ..:|                ||..:||..|...:|              :::.|:....|.|.|:
  Rat  1046 KKAGKMTIGRQYLLKKRTGTIVEERANRPGWNEED--------------DISVSDDCELPTSTTL 1096

  Fly   205 SAAMSNRLQRSVRYESDFKNEVARLGF-DLKGS--------WRISTANADFKLCPSYPPKLLVPC 260
            .|:..:.:::.|  |.....:..|||. .:.||        :|::.:|..:.||.|||..|::|.
  Rat  1097 KASEKSTMEQLV--EKACFRDYQRLGLGTISGSSSRSKPEYFRVTASNRLYSLCRSYPGLLVIPQ 1159

  Fly   261 CITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARC----SQPEVGWLGWRNT------------ 309
            .:.|..|..||......|||.|.|::.:||.:|.|.    .:..||....:|:
  Rat  1160 AVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAVSTSSLESS 1224

  Fly   310 ---RDEQLLKALADAC------------------------------------------------- 322
               ..|:.|:||..|.
  Rat  1225 SSIEQEKYLQALLTAVIVHQKLRGNSTLTVRPTLALSPGTERRSSRMSTVLKQVVPGHLDVNPSN 1289

  Fly   323 AFDRGEHARHSTC---ANAKAQPTKGSKETNGQSG------------------------LSGKS- 359
            :|.||.|.....|   :|:|:    .:||.....|                        |:||.
  Rat  1290 SFARGVHGYRDKCFTQSNSKS----SAKEPVHNQGVWASLRSSTRLISSPTSLIDVGARLAGKDH 1350

  Fly   360 SPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGCE----CIEYYPCAEIEFMNLGNIH 420
            |.|..:|::.:..|.:.:..|      |.....::.|....|    | |:.|   :||   ..|.
  Rat  1351 SASFSNSTYLQNQLSKRQAAL------YIFGEKSQLRSSKVEFAFNC-EFVP---VEF---HEIR 1402

  Fly   421 AIRKSFHAVRQLCASSP-------------DDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKN 472
            .::.||..:.:.|..|.             :|..|:.||.:.|.:          ..||..:.:|
  Rat  1403 QVKASFKKLMRACIPSTIPTDSEVTFLKALEDSEWFPQLHRIMQL----------AVVVSEVLEN 1457

  Fly   473 GRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVN 537
            |..|.|...:|||.|.|:.:..||..||:|||:||||:|||:|||:|||||:.||....|| :.:
  Rat  1458 GSSVWVCLEEGWDITTQVTSLVQLLSDPFYRTIEGFRMLVEKEWLSFGHKFSQRSSLALNS-QGS 1521

  Fly   538 ERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIEN-SVFD--- 598
            ...|:|||:||.|||:|.|||..|||::.||..||.|.:|..|.|||.:|..||:|: ::||
  Rat  1522 GFAPIFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKG 1586

  Fly   599 -----RTFSVWPFLAETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSN 658
                 :...:|..:.:...|:|::               |.|.:|.|.:.:|
  Rat  1587 DKHAKKGVCIWECIDKMHKRSPVF---------------FNYLYSPVEIEAL------------- 1623

  Fly   659 ERQSGHNGLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMFDIRSEANNS 723
                                              .||:.|.|:          ..:|..:|...|
  Rat  1624 ----------------------------------KPNVNVSSL----------KKWDYYTEETLS 1644

  Fly   724 VSENVQESVKDSKEVELDVTD-ATEVGPCGRSNNPIPDFHNDQSTASKRDILEVESQTQRRSSLE 787
            ...:....:...|....:.:| |...||..:.....|.:  |..|.|:.|.|     |:..|.:|
  Rat  1645 AGPSYDWMMLTPKHFPYEESDVAGGAGPQSQRKTVWPCY--DDVTCSQPDAL-----TRLFSEIE 1702

  Fly   788 SSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQSPVPLKSEDTS 852
            ..:                              .|||                |:|
  Rat  1703 KLE------------------------------HKLN----------------QTP--------- 1712

  Fly   853 DISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHITSPTMELVSGDRKLESTSTVQASKISQS 917
                ..||...|..|..|     .::|.:|:|.|....||.:                ||....|
  Rat  1713 ----EKWHQLWEKITMDL-----KEEPRTDHSLRHSSRSPGI----------------ASTNVPS 1752

  Fly   918 YNNLPKVH 925
            |...|.:|
  Rat  1753 YQKRPALH 1760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	34/173 (20%)
		Myotub-related	221..590	CDD:284109	135/490 (28%)
		FYVE_MTMR4	1162..1221	CDD:277272
Sbf2	XP_008758019.1	uDENN	1..86	CDD:214824
		DENN	115..297	CDD:280329
		dDENN	351..419	CDD:129037
		SBF2	530..752	CDD:289132
		PH-GRAM_MTMR13	880..998	CDD:275416	26/123 (21%)
		Myotub-related	1114..1574	CDD:284109	135/487 (28%)
		PH_Sbf1_hMTMR5	1797..1902	CDD:269941
		PH	1802..1902	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740