DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3632 and SBF1

DIOPT Version :9

Sequence 1:	NP_001096996.1	Gene:	CG3632 / 32589	FlyBaseID:	FBgn0030735	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_011529011.1	Gene:	SBF1 / 6305	HGNCID:	10542	Length:	1903	Species:	Homo sapiens

Alignment Length:	785	Identity:	206/785 - (26%)
Similarity:	312/785 - (39%)	Gaps:	200/785 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RAAESYPKSQMEKEDSQLFVPFQELAGESIK-YL---GRTD--------------DGILALSNYR 69
            |.:...|..|..|......:|.:|...:.:: ||   ||.:              :|.:.|:.||
Human   881 RESRRLPPIQKPKLLRPRLLPGEECVLDGLRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYR 945

  Fly    70 IFLSKQSTGYETYVPLGLIESVQVRD-----------------LFQLIVNCKDASTVR-CSFPSA 116
            :..    ||..|...:|  |.|.||.                 :.||:   :|...:| |:|...
Human   946 VIF----TGMPTDPLVG--EQVVVRSFPVAALTKEKRISVQTPVDQLL---QDGLQLRSCTFQLL 1001

  Fly   117 EQCSD----------WQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNG-- 169
            :...|          :::::| .:..|..:...|||        .|||.:..|.........|
Human  1002 KMAFDEEVGSDSAELFRKQLH-KLRYPPDIRATFAF--------TLGSAHTPGRPPRVTKDKGPS 1057

  Fly   170 ------LIAKDRCLTL----------------HNGLAKP---TANVTASNPLPDPASETISAAM- 208
                  .:.|:...|:                |.|...|   ...::.|..| :|::.|.|:|:
Human  1058 LRTLSRNLVKNAKKTIGRQHVTRKKYNPPSWEHRGQPPPEDQEDEISVSEEL-EPSTLTPSSALK 1121

  Fly   209 -SNRLQRSVRYESDFKNEVARLGFDLKGS---------WRISTANADFKLCPSYPPKLLVPCCIT 263
             |:|:..|...|.....:..|||.....|         :|||..|..:.:|.|||..|:||..:.
Human  1122 PSDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQ 1186

  Fly   264 DEMLHNVANFRGSRRLPAVVWRHQKSGAILARC----SQPEVGWLGWRNT-------------RD 311
            |..|..|:......|.|.|.||..:|.|:|.|.    .:..||....:|.             ..
Human  1187 DNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQ 1251

  Fly   312 EQLLKAL-------ADA---------CAFDRGEH-----ARHSTCANAKAQPTK---------GS 346
            |:.|:|:       |||         .:...|.|     ||.:|.:|..|....         ||
Human  1252 EKYLQAVVSSMPRYADASGRNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGS 1316

  Fly   347 KETNGQSG---------LSGKSS---PSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGG 399
            ..|:|:|.         |:|:.:   |..:....:...|...:..|      |......:.:|..
Human  1317 VRTSGRSSGLGTDVGSRLAGRDALAPPQANGGPPDPGFLRPQRAAL------YILGDKAQLKGVR 1375

  Fly   400 CECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLC-----ASSPDDPNWYGQLEKTMWMQHLSGLL 459
            .:.::.:....||......:.|   ||..:.:.|     |:.|...::...||.:.|:..:..||
Human  1376 SDPLQQWELVPIEVFEARQVKA---SFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLL 1437

  Fly   460 GATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFA 524
            ..::.||..:: :|..|||...||||.|.|:|:..||..||:|||:||||:|||:|||:|||:|:
Human  1438 QVSVLVVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFS 1501

  Fly   525 DRSGN---GPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCN 586
            .|..:   |.:|...    |||||:||.|||:|.|:|..||||..||..|..|.:|..|.|||.:
Human  1502 HRGAHTLAGQSSGFT----PVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLD 1562

  Fly   587 SLRERIENSVF-----DR-----TFSVWPFLAETMYRNP-----LYKHETEKVLWPAHSVRFLYF 636
            |..||||..:.     :|     ..|||.::.....|.|     :|..|..:||.|..:|..|..
Human  1563 SDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKV 1627

  Fly   637 WSDVY 641
            | |.|
Human  1628 W-DFY 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	31/157 (20%)
		Myotub-related	221..590	CDD:284109	132/444 (30%)
		FYVE_MTMR4	1162..1221	CDD:277272
SBF1	XP_011529011.1	uDENN	36..92	CDD:281455
		DENN	139..320	CDD:214823
		dDENN	374..442	CDD:129037
		SBF2	553..774	CDD:289132
		PH-GRAM_MTMR5	903..1021	CDD:275417	24/126 (19%)
		Myotub-related	1138..1566	CDD:284109	132/441 (30%)
		PH_Sbf1_hMTMR5	1796..1901	CDD:269941
		PH	1800..1901	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840